27 completed, 9 terminated, 8 recruiting, 8 unknown. 24 Phase 2, 13 Phase 1, 8 Not applicable, 4 Phase 3, 3 Early Phase 1.
Follow Insulinoma: new trials by email Literature Review of Insulinoma trials Research Report on Insulinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of [68Ga]Ga-HBED-CC-PEG6-Exendin-4 and [68Ga]Ga-HBED-CC-Exendin-4 PET/CT for Insulinoma Localization [68Ga]Ga-HBED-CC-PEG6-exendin-4 PET/CT, [68Ga]Ga-HBED-CC-exendin-4 PET/CT - Insulinoma | Not applicable | Recruiting | Peking Union Medical College Hospital | 20 | 2026-10-01 | 2026-09-09 |
| Endoscopic Ultrasound-guided Radiofrequency Ablation for Upper Gastrointestinal Tract Lesions observational study - Insulinoma; Pancreas, MEN1 | Recruiting | Herlev Hospital | 138 | 2025-11-01 | 2025-12-09 | |
| A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism Ersodetug - Tumor Hyperinsulinism (Tumor HI) | Phase 3 | Recruiting | Rezolute | 16 | 2025-04-16 | 2026-09-28 |
| Safety and Efficacy of EUS-RFA in Pancreatic Insulinoma EUS-RFA - Insulinoma; Pancreas | Recruiting | Sahlgrenska University Hospital | 20 | 2025-03-31 | 2026-05-13 | |
| EUS-RFA Versus Surgery for Pancreatic Insulinoma (ERASIN-RCT) Endoscopic ultrasound-guided radio frequency ablation, Surgery - Pancreatic Insulinoma | Not applicable | Active not recruiting | Azienda Ospedaliera Universitaria Integrata Verona | 60 | 2023-03-01 | 2026-01-13 |
| A Multi-center Study to Evaluate the Efficacy and Safety of Pancreatic Duct Stents Placement Before the Enucleation of Insulinoma Located in the Head and Neck of the Pancreas Near the Main Pancreatic Duct placement of pancreatic duct stents before enucleation surgery, Direct enucleation surgery - Insulinoma | Not applicable | Unknown | Peking Union Medical College Hospital | 78 | 2023-02-06 | 2023-11-02 |
| Clinical Study of 18F-Exendin-4 in Insulinoma Insulinoma | Completed | Sichuan Provincial People's Hospital | 20 | 2023-02-01 | 2026-01-15 | |
| 177Lu-DOTATOC for the Treatment of Patients With Somatostatin Receptor Positive NETs 177Lu-DOTATOC - Neuroendocrine Tumors, Carcinoid Tumor | Phase 2 | Withdrawn | British Columbia Cancer Agency | 2023-01-15 | 2023-02-21 | |
| [68Ga]Ga-HBED-CC-exendin-4 and [68Ga]Ga-NOTA-exendin-4 PET/CT Imaging in the Same Group of Insulinoma Patients [68Ga]Ga-HBED-CC-exendin-4, [68Ga]Ga-NOTA-exendin-4 - Insulinoma | Early Phase 1 | Unknown | Peking Union Medical College Hospital | 20 | 2021-10-01 | 2022-10-14 |
| Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism 18F-Fluoro Dopa PET/MRI Imaging - Hyperinsulinism | Phase 2 | Recruiting | Washington University School of Medicine | 100 | 2020-09-10 | 2025-12-19 |
| The Clinical Application of 68Ga-NOTA-exendin-4 PET/CT in Detecting Insulinoma 68Ga-NOTA-exendin-4 - Insulinoma | Phase 1 | Unknown | First Affiliated Hospital of Fujian Medical University | 60 | 2020-08-01 | 2023-09-21 |
| CGM (Continuous Glucose Monitoring) Use in Diagnosis of Spontaneous and Reactive Hypoglycaemia use of continuous glucose monitoring - Hypoglycemia, Reactive, Hypoglycaemia Night | Not applicable | Terminated | Barts & The London NHS Trust | 7 | 2019-12-01 | 2023-12-12 |
| Clinical Evaluation of 68Ga-NOTA-MAL-Cys39-exendin-4 Positron Emission Tomography in the Detection of Insulinoma 68Ga-NOTA-MAL-Cys39-exendin-4 - Insulinoma | Early Phase 1 | Unknown | Nanjing First Hospital, Nanjing Medical University | 60 | 2019-05-05 | 2019-12-04 |
| Application of Raw Corn Starch on Patients With Insulinoma low GI diet with regular supplementation of raw corn starch - Hyperinsulinemic Hypoglycemia, Insulinoma | Not applicable | Unknown | Peking Union Medical College Hospital | 20 | 2019-04-15 | 2019-04-29 |
| Glucagon-like Peptide-1 Receptor PET/CT in GLP-1R Related Disease 18F/68Ga-Exendin 4 - GLP1-R-related Disease, Tumor | Recruiting | Tianjin Medical University | 500 | 2019-02-01 | 2026-09-08 | |
| DOTATOC PET/CT for Imaging NET Patients 68Ga-DOTATOC PET/CT, 18F-FDG PET/CT - Neuroendocrine Tumors, Insulinoma | Active not recruiting | British Columbia Cancer Agency | 800 | 2018-07-11 | 2026-05-12 | |
| Laser Tissue Welding - Distal Pancreatectomy Sealing Study Distal Pancreatectomy Sealing Using LTW - Pancreatic Tumor, Benign, Pancreatic Neoplasms | Phase 1 | Completed | Laser Tissue Welding, Inc. | 11 | 2018-01-01 | 2022-04-06 |
| Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Capecitabine, Temozolomide, Veliparib - Functional Pancreatic Neuroendocrine Tumor, Malignant Somatostatinoma | Phase 1 | Withdrawn | Vanderbilt-Ingram Cancer Center | 2017-12-01 | 2017-09-28 | |
| Pasireotide in Hyperinsulinemic Hypoglycemia Pasireotide 0.6Mg Solution for Injection, Saline Solution - Congenital Hyperinsulinism, Insulinoma | Phase 2 | Withdrawn | Montefiore Medical Center | 2017-04-01 | 2021-05-14 | |
| Regorafenib in Treating Patients With Advanced or Metastatic Neuroendocrine Tumors regorafenib, laboratory biomarker analysis - Gastrinoma, Glucagonoma | Phase 2 | Completed | University of Southern California | 3 | 2016-08-16 | 2021-12-15 |
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Glucagonoma (33) · Somatostatinoma (31) · Gastrinoma (30) · Carcinoma, Islet Cell (26) · Vipoma (20) · Adenoma, Islet Cell (17) · Neoplasms (15) · Carcinoma, Medullary (10) · Hypoglycemia (9) · Pheochromocytoma (9) · Neuroendocrine Tumors (8) · Pancreatic Neoplasms (8) · Hyperinsulinism (7) · Carcinoma, Renal Cell (6)
Adenoma (62) · Digestive System Diseases (62) · Digestive System Neoplasms (62) · Endocrine Gland Neoplasms (62) · Endocrine System Diseases (62) · Neoplasms by Histologic Type (62) · Neoplasms by Site (62) · Neoplasms, Glandular and Epithelial (62) · Pancreatic Diseases (62) · Pancreatic Neoplasms (54) · Neoplasms (47) · Adenoma, Islet Cell (45) · Neoplasms, Germ Cell and Embryonal (39) · Neuroectodermal Tumors (39) · Adenocarcinoma (37)
Capecitabine (4) · Everolimus (4) · Octreotide (4) · fluorodopa F 18 (4) · Leucovorin (3) · Temozolomide (3) · 68Ga-NOTA-exendin-4 (2) · Bevacizumab (2) · Bortezomib (2) · Fluorouracil (2) · Oxaliplatin (2) · Trastuzumab (2) · vatalanib (2) · 177Lu-octreotide, DOTA(0)-Tyr(3)- (1) · 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one (1)
National Cancer Institute (NCI) (8) · Peking Union Medical College Hospital (5) · British Columbia Cancer Agency (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · ECOG-ACRIN Cancer Research Group (2) · Eastern Cooperative Oncology Group (2) · Memorial Sloan Kettering Cancer Center (2) · Rezolute (2) · Vanderbilt-Ingram Cancer Center (2) · Yale University (2) · Academic and Community Cancer Research United (1) · Azienda Ospedaliera Universitaria Integrata Verona (1) · Barts & The London NHS Trust (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Children's Hospital of Philadelphia (1)
United States (35) · China (10) · United Kingdom (4) · Canada (3) · Denmark (2) · Italy (2) · Netherlands (2) · Sweden (2) · Switzerland (2) · France (1) · Germany (1) · Greece (1) · Israel (1) · Poland (1) · Spain (1)
Francois Benard, MD (2) · James Yao (2) · Leonard B. Saltz, MD (2) · Mary Mulcahy, MD (2) · Timothy Hobday (2) · Ana Maria Arbelaez, MD, MSCI (1) · Anthony W. Tolcher, MD (1) · Arkadiusz Dudek, MD (1) · Bojan Kovacevic, MD, ph.d. (1) · Damian Wild, MD (1) · Emily Bergsland (1) · Emily K. Bergsland, MD (1) · Erika Brutsaert, M.D., M.P.H. (1) · Fang Li, MD (1) · Feng Wang, Ph.D (1)
PMID 18703486, PMID 19820010, PMID 20847174, PMID 21831734, PMID 22480131, PMID 22722717, PMID 25900182, PMID 25956795, PMID 27020837, PMID 29853660, PMID 36260828, PMID 38569703, PMID 39499011, PMID 39863139, PMID 40259061
N01CM62205 (2), P30CA016672 (2), U01CA076576 (2), U10CA021115 (2), 2014 (1), N01CM62202 (1), P30CA014089 (1), R44CA203052 (1), U01CA062461 (1), U01CA062490 (1), U10CA023318 (1), U10CA180820 (1), ZIAEB000073 (1)