27 completed, 12 terminated, 3 recruiting, 3 unknown. 46 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 46 | Completed 27, Terminated 12, Recruiting 3, Unknown 3, Withdrawn 1 |
| Phase 2 | 6 | Completed 3, Terminated 2, Recruiting 1 |
Follow Hyperphagia: new trials by email Literature Review of Hyperphagia trials Research Report on Hyperphagia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PROGAIN Trial in Gastric Cancer Surgery Protein-enriched peripheral parenteral nutrition (Winuf A+ injection), Standard peripheral parenteral nutrition (Winuf injection) - Stomach (Gastric) Cancer | Phase 3 | Recruiting | Soonchunhyang University Hospital | 110 | 2026-02-13 | 2026-05-19 |
| Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral Support Choline Chloride for Injection, Placebo - Choline Deficiency, Liver Injury | Phase 2 / Phase 3 | Recruiting | Protara Therapeutics | 129 | 2025-12-10 | 2026-08-24 |
| ARD-101 for Treatment of PWS: The Hunger Elimination or Reduction Objective Trial Placebo, ARD-101 - Hyperphagia, Prader-Willi Syndrome | Phase 3 | Terminated | Aardvark Therapeutics, Inc. | 68 | 2024-12-20 | 2026-06-30 |
| Clinical Trial to Evaluate the Safety and Efficacy of NTCB02-1 in Patients Who Require Parenteral Nutrition NTCB02-1, NTCB-C - Parenteral Nutrition | Phase 3 | Recruiting | Yuhan Corporation | 60 | 2024-12-04 | 2025-01-07 |
| Clinical Trial to Evaluate the Safety and Efficacy of NTCB01-1 in Patients Who Require Parenteral Nutrition NTCB01-1, NTCB-P - Parenteral Nutrition | Phase 3 | Completed | Yuhan Corporation | 60 | 2024-11-14 | 2025-05-15 |
| The Hunger Elimination or Reduction Objective (HERO ) Open -Label Extension (OLE) Trial ARD-101 - Hyperphagia, Prader-Willi Syndrome | Phase 3 | Terminated | Aardvark Therapeutics, Inc. | 19 | 2024-07-23 | 2026-06-30 |
| Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutrition sodium acetate group will receive sodium acetate in the neonatal PN., sodium chloride group will receive sodium chloride in the neonatal PN. - Metabolic Acidosis, Neonatal Disease | Phase 3 | Unknown | Aga Khan University Hospital, Pakistan | 200 | 2024-07-10 | 2024-08-09 |
| A Phase Ⅲ Study of HR19006 Injection in Postsurgical Parenteral Nutrition HR19006, All-in-one parenteral nutrition - Parenteral Nutrition | Phase 3 | Unknown | Fujian Shengdi Pharmaceutical Co., Ltd. | 240 | 2023-04-28 | 2023-10-10 |
| Clinical Trial to Evaluate the Safety and Efficacy of IN-C006 Peri Inj. Compared With RPN301 IN-C006 Peri inj., RPN301 - Parenteral Nutrition | Phase 3 | Completed | HK inno.N Corporation | 59 | 2022-08-09 | 2023-09-28 |
| Clinical Trial to Evaluate the Safety and Efficacy of IN-C006 Inj. Compared With RCN301 IN-C006 inj., RCN301 - Parenteral Nutrition | Phase 3 | Completed | HK inno.N Corporation | 60 | 2022-05-04 | 2023-09-28 |
| EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway Setmelanotide, Placebo - Obesity, Genetic Obesity | Phase 3 | Completed | Rhythm Pharmaceuticals, Inc. | 296 | 2022-04-26 | 2026-11-12 |
| Oral Naltrexone In Pediatric Eating Disorders Naltrexone Hydrochloride, Control - Anorexia Nervosa/Bulimia, Anorexia in Adolescence | Phase 2 / Phase 3 | Terminated | Rosemary Claire Roden | 9 | 2022-04-22 | 2025-08-19 |
| Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Participants With Specific Gene Defects in the MC4R Pathway Setmelanotide 2 mg, Setmelanotide 2.5 mg, Setmelanotide 3 mg - Bardet-Biedl Syndrome, POMC Deficiency | Phase 3 | Completed | Rhythm Pharmaceuticals, Inc. | 19 | 2021-12-21 | 2024-11-26 |
| Efficacy and Safety of Numeta G13%E Compared to Compounded Parenteral Nutrition in Preterm Neonates Numeta G13%E, Compounded Parenteral Nutrition (cPN) solution - Malnutrition, Infant, Enteral Feeding Intolerance | Phase 3 | Withdrawn | Baxter Healthcare Corporation | 2021-08-20 | 2025-04-24 | |
| Effects of Livoletide (AZP-531) on Food-related Behaviors in Patients With Prader-Willi Syndrome Livoletide, Placebo - Prader-Willi Syndrome, Hyperphagia | Phase 2 / Phase 3 | Terminated | Millendo Therapeutics SAS | 158 | 2019-03-25 | 2021-02-17 |
| Efficacy & Safety of SmofKabiven Emulsion for Infusion vs Hospital Compounded "All in One" for Parenteral Nutrition SmofKabiven emulsion for infusion, Hospital compounded "All in one" emulsion - Parenteral Nutrition, Surgery | Phase 3 | Completed | Fresenius Kabi | 273 | 2019-01-03 | 2021-08-02 |
| Omegaven as Alternative Parenteral Fat Nutrition Omegaven - Cholestasis, Cholestasis of Parenteral Nutrition | Phase 3 | Completed | University of South Florida | 2 | 2018-10-23 | 2020-07-22 |
| Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the Head and Neck Standard care of parenteral nutrition, Parenteral over night nutrition, Cetuximab - Squamous Cell Carcinoma of the Hypopharynx Stage III, Squamous Cell Carcinoma of the Hypopharynx Stage IV | Phase 3 | Terminated | Arbeitsgemeinschaft medikamentoese Tumortherapie | 8 | 2017-02-03 | 2020-05-01 |
| Peripheral Parenteral Nutrition vs Conventional Fluid in Colorectal Resection in ERAS Perioperative peripheral parenteral nutrition - Colon Cancer, Parenteral Nutrition | Phase 3 | Unknown | Antonio Arroyo Sebastian | 200 | 2016-10-01 | 2018-07-31 |
| Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition Teduglutide 0.05mg/kg, Teduglutide 0.025 mg/kg, Standard of Care - Short Bowel Syndrome | Phase 3 | Completed | Shire | 59 | 2016-06-23 | 2021-06-09 |
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Short Bowel Syndrome (6) · Obesity (5) · Prader-Willi Syndrome (5) · Bulimia (4) · Premature Birth (4) · Cholestasis (3) · Binge-Eating Disorder (2) · Feeding and Eating Disorders (2) · Infant Nutrition Disorders (2) · Liver Diseases (2) · Sepsis (2) · Acidosis (1) · Anorexia Nervosa (1) · Bardet-Biedl Syndrome (1)
Pathological Conditions, Signs and Symptoms (46) · Signs and Symptoms (46) · Signs and Symptoms, Digestive (46) · Digestive System Diseases (15) · Nutritional and Metabolic Diseases (14) · Nutrition Disorders (12) · Gastrointestinal Diseases (10) · Pathologic Processes (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Intestinal Diseases (8) · Overnutrition (8) · Overweight (8) · Abnormalities, Multiple (6) · Congenital Abnormalities (6) · Genetic Diseases, Inborn (6)
soybean oil, phospholipid emulsion (6) · teduglutide (6) · ALX-0600 (5) · Fish Oils (3) · fish oil triglycerides (3) · Fat Emulsions, Intravenous (2) · Parenteral Nutrition (2) · Soybean Oil (2) · setmelanotide (2) · Bupropion (1) · CKD732 (1) · Cetuximab (1) · Choline (1) · Cisplatin (1) · ClinOleic (1)
Shire (6) · Baxter Healthcare Corporation (3) · Fresenius Kabi (3) · Aardvark Therapeutics, Inc. (2) · HK inno.N Corporation (2) · Rhythm Pharmaceuticals, Inc. (2) · Yuhan Corporation (2) · Aga Khan University Hospital, Pakistan (1) · Antonio Arroyo Sebastian (1) · Arbeitsgemeinschaft medikamentoese Tumortherapie (1) · B. Braun Melsungen AG (1) · Coordinación de Investigación en Salud, Mexico (1) · Emory University (1) · Fujian Shengdi Pharmaceutical Co., Ltd. (1) · Hospices Civils de Lyon (1)
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David Meeker, MD (2) · Abbot R. Laptook, MD (1) · Antonio Arroyo, MD (1) · Avroy A. Fanaroff, MD (1) · Barbara J. Stoll, MD (1) · Brenda B. Poindexter, MD MS (1) · Charles R. Bauer, MD (1) · David K. Stevenson, MD (1) · Dennis Kim, MD (1) · Didier Barnoud, MD (1)
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