45 completed, 8 terminated, 7 withdrawn, 4 recruiting. 20 Not applicable, 20 Phase 4, 16 Phase 3, 10 Phase 2, 5 Phase 1.
Follow soybean oil, phospholipid emulsion: new trials by email Literature Review of soybean oil, phospholipid emulsion trials Research Report on soybean oil, phospholipid emulsion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Insulin and Insulin Pulses During Fasting Intralipid and heparin, Saline - PreDiabetes | Not applicable | Recruiting | Mayo Clinic | 60 | 2024-09-15 | 2026-10-07 |
| Role of Intralipid in Management of Organophosphorus Poisoning Intralipid, 20% Intravenous Emulsion, Intravenous Atropine Sulfate - Organophosphorus Poisoning | Phase 2 / Phase 3 | Withdrawn | Amani Hassan Abdel-Wahab | 2024-04-01 | 2025-10-03 | |
| South African Male User Research on Acceptability of Implants and Injections Placebo injection: Intralipid 20% fat emulsion, Placebo implant - Acceptability | Not applicable | Completed | RTI International | 184 | 2022-07-12 | 2025-04-06 |
| Reversing Glucose and Lipid-mediated Vascular Dysfunction Dextrose 20 % in 500 ML Injection, Intralipid, Saline - Blood Pressure, Hypertension | Early Phase 1 | Recruiting | University of Kansas Medical Center | 46 | 2022-05-09 | 2025-06-05 |
| Endogenous GLP-1 Secretion on Islet Function in People With and Without Type 2 Diabetes Saline, Exendin-9,39, Saline + Intralipid/Heparin - Healthy, Type 2 Diabetes | Phase 3 | Completed | Adrian Vella | 23 | 2021-04-15 | 2023-12-26 |
| Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion (Part A) Clinolipid, Intralipid - Essential Fatty Acid Deficiency (EFAD) | Phase 4 | Completed | Baxter Healthcare Corporation | 101 | 2021-01-22 | 2023-12-27 |
| Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism Intralipid, 20% Intravenous Emulsion, Placebos - Obesity | Phase 1 / Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 40 | 2020-12-08 | 2025-03-30 |
| The Cardioprotective Effect of Intralipid in Decreasing the Ischemic Insults During Off-pump Coronary Artery Revascularization Intralipid, Placebo - Anesthesia | Phase 4 | Completed | Ain Shams University | 46 | 2020-10-01 | 2021-03-19 |
| Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle Intralipid, 20% Intravenous Emulsion, MitoQ, Salbutamol - Insulin Resistance | Not applicable | Completed | University of Copenhagen | 10 | 2020-09-02 | 2021-12-02 |
| Dose Intralipid Infusion Reduces Pregnancy Complications Caused by Antiphospholipid Antibody Syndrome? Intralipid, 20% Intravenous Emulsion, Conventional therapy of antiphospholipis syndrome - Antiphospholipid Syndrome in Pregnancy | Phase 4 | Withdrawn | Tanta University | 2020-04-01 | 2021-06-14 | |
| Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion Somatostatin, Dextrose, Insulin - Healthy | Phase 4 | Withdrawn | Mayo Clinic | 2020-02-01 | 2022-09-09 | |
| Low Dose Fat-Induced Insulin Resistance Intralipid, 20% Intravenous Emulsion - Diabetes Mellitus, Type 2, Insulin Resistance | Early Phase 1 | Completed | University of Pennsylvania | 9 | 2020-01-01 | 2026-04-15 |
| Safety and Efficacy Study to Compare Smoflipid and Intralipid 20% in Pediatric Patients of 3 Months to 16 Years of Age Smoflipid, Intralipid, 20% - Malnutrition, Child | Phase 4 | Terminated | Fresenius Kabi | 1 | 2019-12-18 | 2022-12-12 |
| Omega 3 Fatty Acid Treatment for Pediatric Musculoskeletal Health Omegaven, Intralipid - Esophageal Atresia | Phase 2 | Withdrawn | Boston Children's Hospital | 2019-09-01 | 2019-09-16 | |
| Intralipid® 20% for Reversal of Local Anesthetics Lidocaine 2%, Lidocaine 1%, Bupivacaine 0.25% - Anesthesia, Local | Phase 4 | Active not recruiting | Hospital for Special Surgery, New York | 18 | 2019-07-26 | 2025-12-08 |
| Impact of Plasma Lipids on β Cell Function and Insulin Sensitivity 20% Intralipid, Normal Saline - Hypertriglyceridemia, Glucose Intolerance | Not applicable | Completed | Azienda Ospedaliero, Universitaria Pisana | 12 | 2019-04-30 | 2022-01-06 |
| The Effect of Lipid Emulsions on Free Fatty Acids and Free Bilirubin in Premature Newborns Intralipid, 20% Intravenous Emulsion, Soybean oil Medium-chain triglycerides Olive oil Fish Oil (SMOF) lipid - Prematurity | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 66 | 2019-03-02 | 2025-03-03 |
| Intralipid Versus SMOFlipid in HPN Patients SMOFLipid, Intralipid - Short Bowel Syndrome, Intestinal Fistula | Not applicable | Completed | Mayo Clinic | 22 | 2018-12-31 | 2025-05-16 |
| Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids Intralipid, Palm Oil Emulsion, Saline - Insulin Resistance | Not applicable | Recruiting | Mayo Clinic | 60 | 2018-12-01 | 2026-01-12 |
| Comparison of Smoflipid to Soy-based Lipid Reduction for Cholestasis Prevention in Surgical Neonates Smoflipid 20% Lipid Emulsion for Injection, Intralipid, 20% Intravenous Emulsion - Cholestasis of Parenteral Nutrition | Phase 3 | Completed | Indiana University | 24 | 2018-11-30 | 2025-07-30 |
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Hyperphagia (20) · Insulin Resistance (10) · Cholestasis (6) · Premature Birth (5) · Diabetes Mellitus, Type 2 (4) · Obesity (4) · Short Bowel Syndrome (4) · Abortion, Habitual (3) · Hypertension (3) · Inflammation (3) · Glucose Intolerance (2) · Hypertriglyceridemia (2) · Infections (2) · Infertility (2) · Liver Diseases (2)
Mayo Clinic (5) · Emory University (3) · Fresenius Kabi (3) · Baxter Healthcare Corporation (2) · Beth Israel Deaconess Medical Center (2) · Boston Children's Hospital (2) · Johane Allard (2) · Woman's Health University Hospital, Egypt (2) · Adrian Vella (1) · Ahmed Mohamed Bahaa Eldin Ahmed (1) · Ain Shams University (1) · Alexandra N. Carey (1) · Amani Hassan Abdel-Wahab (1) · Assistance Publique - Hôpitaux de Paris (1) · AstraZeneca (1)
United States (36) · Canada (6) · Egypt (5) · China (4) · France (4) · Denmark (3) · Netherlands (3) · Australia (2) · Austria (2) · India (2) · Japan (2) · Poland (2) · Russia (2) · Spain (2) · Sweden (2)
Guillermo Umpierrez, MD (3) · Adrian Vella, MD (2) · Adrian Vella (1) · Alaa M Ismail, M D (1) · Alexandra N Carey, MD (1) · Aminah Jatoi, M.D. (1) · Andrea Natali, MD (1) · Andreas Repa, MD (1) · Bara Ricou, Prof. (1) · Belal Alshaikh, MD,MSc (1) · Camilia R Martin, MD (1) · Charles C Oh, MD (1) · Christopher Duggan, MD, MPH (1)
PMID 20473991, PMID 20531018, PMID 20923960, PMID 21199856, PMID 21832112, PMID 22237883, PMID 22488002, PMID 22639293, PMID 23770843, PMID 25027101, PMID 26561301, PMID 27333588, PMID 27404223, PMID 27614789, PMID 27743205, PMID 29269199, PMID 29882073, PMID 30962688, PMID 30994855, PMID 31030946, PMID 32184607, PMID 32590001, PMID 32798567, PMID 33838870, PMID 34090870, PMID 35659521, PMID 35961260, PMID 36257349, PMID 37751301, PMID 38190077, PMID 38710978, PMID 39374788, PMID 40415417, PMID 42615126
R01DK045343 (1), R01DK078646 (1), R01DK123227 (1), R01DK126206 (1), UG1CA189823 (1), UL1TR001082 (1)