15 completed, 4 unknown, 2 active not recruiting, 2 not yet recruiting. 10 Not applicable, 8 Phase 1, 3 Phase 2, 1 Early Phase 1, 1 Phase 4.
Follow Hyperinsulinemia: new trials by email Literature Review of Hyperinsulinemia trials Research Report on Hyperinsulinemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Human Models of Selective Insulin Resistance: Pancreatic Clamp Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Hyperinsulinemia | Phase 1 | Not yet recruiting | Columbia University | 36 | 2027-01-01 | 2026-02-06 |
| Effect of Insulin Lowering on Lipogenesis Placebo, Diazoxide Oral Suspension, 2 mg per kg per dose, Deuterated water (2H2O/D2O), 70% - Hyperinsulinemia, Insulin Resistance | Phase 1 | Recruiting | Columbia University | 25 | 2026-07-01 | 2026-07-06 |
| Application of FreeStyle Libre 2 for Evaluating Glycemic Variability Characteristics in Patients With Extreme Glucose Metabolism Phenotypes Monogenic Diabetes, Hyperinsulinemia | Not yet recruiting | Peking University People's Hospital | 120 | 2026-05-25 | 2026-06-02 | |
| Effect of a Sugar Replacement on Blood Glucose Levels in Healthy Adults Galacto-Oligosaccharide, Glucose - Postprandial Hyperglycemia, Hyperinsulinemia | Not applicable | Active not recruiting | University of Aberdeen | 50 | 2025-01-17 | 2026-06-18 |
| Diazoxide Suppression Test P&F Study Diazoxide, 3 mg/kg per dose - Insulin Resistance, Hyperinsulinemia | Phase 1 | Terminated | Columbia University | 1 | 2024-10-23 | 2026-08-07 |
| Graded Insulin Suppression Test P&F Insulin regular, 2.0-3.2 mU/m2/min (euinsulinemia), Insulin regular, 32 mU/m2/min (hyperinsulinemia), Octreotide Acetate, 6-45 ng/kg/min - Insulin Resistance, Hyperinsulinemia | Phase 1 | Completed | Columbia University | 20 | 2024-09-16 | 2026-10-16 |
| The Movie Theater Study Fasting Trial, Fed Trial - Hyperglycemia, Postprandial, Hyperinsulinemia | Not applicable | Unknown | Ball State University | 10 | 2024-03-24 | 2024-06-06 |
| Pancreatic Clamp in NAFLD Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Prediabetic State | Phase 1 | Completed | Columbia University | 18 | 2023-08-29 | 2026-01-12 |
| Glycemic Effect of Diazoxide in NAFLD Diazoxide oral suspension, 1 mg per kg per dose, Diazoxide oral suspension, 2 mg per kg per dose, Placebo - Hyperinsulinemia, Insulin Resistance | Phase 1 | Completed | Columbia University | 22 | 2023-08-01 | 2026-09-30 |
| Hyperinsulinemia in Prediabetes Mediated by Interleukin-1β Anakinra, Placebo - Hyperinsulinemia, PreDiabetes | Phase 2 | Completed | University Hospital, Basel, Switzerland | 20 | 2023-06-15 | 2025-01-29 |
| Effect of Alpelisib in Healthy Volunteers Alpelisib 150 mg [Piqray], 2 overencapsulated tablets (total: 300 mg), Placebo (microcrystalline cellulose), 2 capsules, FreeStyle Libre Pro - Insulin Resistance, Hyperinsulinemia | Phase 1 | Completed | Columbia University | 23 | 2023-05-09 | 2023-12-21 |
| Time-restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian Syndrome Time restricted eating, Normal ad libitum diet - PCOS, Hyperinsulinemia | Not applicable | Unknown | Ruairí Floyd | 20 | 2021-05-05 | 2022-09-19 |
| Saliva Insulin Responses to a Standardized Meal Tolerance Test in Humans Dietary intervention - Diet Modification, Insulin Resistance | Not applicable | Unknown | University of British Columbia | 150 | 2019-01-04 | 2021-09-28 |
| Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Adrenal Gland Neoplasm, Hypertension | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 1150 | 2017-12-14 | 2026-10-26 | |
| Developing a Physiological Understanding of High Duration Activity Muscular Exercise - Sedentary Lifestyle, Hyperinsulinemia | Not applicable | Unknown | University of Houston | 60 | 2016-08-01 | 2023-05-19 |
| A Cold Physical Treatment to Manage Insulin Resistance Selective Cold, Electroacupuncture - Insulin Resistance, Hyperglycemia | Not applicable | Completed | First Affiliated Hospital Xi'an Jiaotong University | 33 | 2016-07-01 | 2020-04-30 |
| Reprometabolic Syndrome Mediates Subfertility in Obesity Insulin, Intralipid, Dextrose - Obesity, Infertility | Not applicable | Active not recruiting | University of Colorado, Denver | 84 | 2016-06-01 | 2026-03-02 |
| Maternal Lifestyle and Neonatal Hypoglycemia Daily brisk walking plus a carbohydrate-restricted diet - Hyperinsulinemia, Miscarriages | Not applicable | Completed | Hospital dos Servidores do Estado do Rio de Janeiro | 480 | 2011-03-01 | 2016-09-29 |
| Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia Metformin, Dietary Modification - Acanthosis Nigricans, Hyperinsulinemia | Completed | Henry Ford Health System | 9 | 2009-02-01 | 2012-09-06 | |
| EMPOWIR:Enhance the Metabolic Profile of Women With Insulin Resistance metformin and rosiglitazone - Hyperinsulinemia, Insulin Resistance | Phase 2 | Completed | New York Medical College | 46 | 2008-01-01 | 2014-03-28 |
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Hyperinsulinism (27) · Insulin Resistance (16) · Obesity (11) · Diabetes Mellitus (5) · Non-alcoholic Fatty Liver Disease (5) · Prediabetic State (5) · Diabetes Mellitus, Type 2 (3) · Dyslipidemias (3) · Hyperglycemia (3) · Pediatric Obesity (3) · Glucose Intolerance (2) · Hypertension (2) · Motor Activity (2) · Overweight (2) · Sedentary Behavior (2)
Metabolic Diseases (27) · Nutritional and Metabolic Diseases (27) · Glucose Metabolism Disorders (26) · Body Weight (13) · Nutrition Disorders (13) · Overnutrition (13) · Pathological Conditions, Signs and Symptoms (13) · Signs and Symptoms (13) · Endocrine System Diseases (12) · Overweight (11) · Diabetes Mellitus (6) · Digestive System Diseases (5) · Fatty Liver (5) · Liver Diseases (5) · Lipid Metabolism Disorders (4)
Insulin (6) · Glucose (5) · Metformin (5) · Diazoxide (3) · Glucagon (3) · Octreotide (3) · Deuterium Oxide (2) · Diet Therapy (2) · Human Growth Hormone (2) · Rosiglitazone (2) · 4'-galactooligosaccharide (1) · Alpelisib (1) · Anticoagulants (1) · Electroacupuncture (1) · Fatty Acids, Nonesterified (1)
Columbia University (7) · Yale University (2) · Ball State University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Henry Ford Health System (1) · Hospital dos Servidores do Estado do Rio de Janeiro (1) · Jack Yanovski, M.D. (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · New York Medical College (1) · Peking University People's Hospital (1) · Ruairí Floyd (1) · University Hospital, Basel, Switzerland (1)
United States (19) · Brazil (1) · Canada (1) · China (1) · Ireland (1) · Switzerland (1) · United Kingdom (1)
Joshua R Cook, MD, PhD (6) · Bryant Keirns (1) · Harriette R Mogul, MD MPH (1) · Iltefat Hamzavi, M.D. (1) · Jack A Yanovski, MD, PhD (1) · Joshua R. Cook, MD, PhD (1) · Karen Scott, PhD (1) · Katherine N Bachmann, MD (1) · Kathleen Mulligan (1) · Li Qiang, Ph.D. (1) · Lucy-Ann Behan, MD (1) · Marc Donath, Prof. (1) · Marc T Hamilton, Ph.D. (1) · Maria A Sayeg-Porto, MD, PhD (1) · Nanette Santoro, MD (1)
PMID 17595270, PMID 18761646, PMID 21228310, PMID 25259787, PMID 25483291, PMID 26789348, PMID 29718281, PMID 33838870, PMID 38271099, PMID 38710978, PMID 41532393
K12DK133995 (2), P30DK063608 (2), 2023 (1), K23DK140614 (1), UL1TR001082 (1)