14 completed, 2 terminated, 1 active not recruiting, 1 not yet recruiting. 8 Not applicable, 5 Phase 4, 4 Phase 2, 3 Phase 1, 1 Early Phase 1.
Follow picolinic acid: new trials by email Literature Review of picolinic acid trials Research Report on picolinic acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Chromium Weight Reduction on Adult Asthma Control Chromium picolinate - Asthma Chronic, Bronchial Asthma | Not applicable | Not yet recruiting | Cairo University | 60 | 2026-08-20 | 2026-07-14 |
| BPPV Recurrence After CRM With & Without Supplementation Combined vitamin D₃ and K₂ supplementation, Vitamin D₃ alone, Canalith repositioning maneuver (CRM) alone - Benign Paroxismal Positional Vertigo | Early Phase 1 | Completed | University of Jordan | 404 | 2025-01-01 | 2026-10-06 |
| Efficacy of Chromium Picolinate in Reducing Acanthosis Nigricans Severity in Adolescents With Insulin Resistance Chromium picolinate, Placebo matching Chromium Picolinate - Insulin Resistance, Acanthosis Nigricans | Not applicable | Completed | Uruk University | 90 | 2025-01-01 | 2026-02-23 |
| Effect of Chromium on Blood Sugar After Sacroiliac Joint Injection Chromium - Sacro Iliac Joint Pain, Diabetes | Phase 4 | Active not recruiting | Fayoum University | 60 | 2024-06-03 | 2024-11-29 |
| Efficacy of the Mobile Application for Prediction and Prevention of Mood Episode Recurrence Based on Machine Learning Circadian Rhythms for Mood (CRM) application - Active, Circadian Rhythms for Mood (CRM) application - Sham - Major Depressive Disorder, Bipolar 1 Disorder | Not applicable | Completed | Hucircadian | 93 | 2022-05-27 | 2025-03-17 |
| Can SARS-CoV-2 Viral Load and COVID-19 Disease Severity be Reduced by Resveratrol-assisted Zinc Therapy Zinc Picolinate, Resveratrol, Zinc Picolinate Placebo - Covid19, SARS-CoV Infection | Phase 2 | Terminated | Swedish Medical Center | 45 | 2020-09-08 | 2022-07-29 |
| Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation Zinc Picolinate 15 Mg - DNA Damage, Immune System Disorder | Phase 2 | Recruiting | University of New Mexico | 100 | 2019-05-19 | 2026-06-04 |
| The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL-1β Zinc, Nifedipine, Beta Carotene - PreTerm Birth | Phase 4 | Completed | Universitas Indonesia | 56 | 2017-01-01 | 2017-11-21 |
| The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Beta carotene, Vitamin D3, Zinc - Hyaline Membrane Disease, Necrotizing Enterocolitis of Newborn | Phase 4 | Unknown | Universitas Indonesia | 120 | 2017-01-01 | 2018-08-13 |
| Binge Eating and Chromium Study Sugar Pill, chromium picolinate - Binge Eating Disorder | Phase 1 / Phase 2 | Completed | University of North Carolina, Chapel Hill | 26 | 2008-07-01 | 2012-04-03 |
| Chromium's Effect on Insulin Resistance in Obesity chromium picolinate - Insulin Resistance, Obesity | Not applicable | Completed | Stony Brook University | 40 | 2007-04-01 | 2011-08-12 |
| Pilot Trial of Chromium-Metformin Combination in Type 2 Diabetes Chromium Picolinate - Type 2 Diabetes | Phase 1 | Terminated | Bastyr University | 40 | 2006-01-01 | 2007-10-31 |
| Use of a Nutritional Supplement to Treat Diabetic Symptoms in HIV-Infected Adults chromium picolinate - Insulin Resistance, HIV Infections | Phase 1 / Phase 2 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 39 | 2005-11-01 | 2016-03-23 |
| Novel Therapy for Glucose Intolerance in HIV Disease Chromium Picolinate - Insulin Resistance | Completed | Stony Brook University | 47 | 2005-06-01 | 2013-12-10 | |
| Effects of Chromium Picolinate on Food Intake Chromium Picolinate - Obesity, Atypical Depression | Not applicable | Completed | Pennington Biomedical Research Center | 42 | 2005-04-01 | 2016-02-12 |
| Chromium Picolinate for the Treatment of Metabolic Syndrome Chromium picolinate - Metabolic Syndrome X, Prediabetic State | Not applicable | Completed | National Center for Complementary and Integrative Health (NCCIH) | 60 | 2004-01-01 | 2006-08-18 |
| A 30 Day Acute Efficacy and Safety Study of Chromium Picolinate + Biotin on Glycemic Control in Overweight or Obese Subjects With T2DM Chromium Picolinate (600 mcg Cr+3) + biotin (2 mg) - Diabetes Mellitus, Type 2 | Not applicable | Completed | Nutrition 21, Inc. | 40 | 2003-11-01 | 2006-03-29 |
| Effect of Chromium Picolinate on Insulin Sensitivity in Type 2 Diabetes chromium picolinate 1000 mcg daily vs placebo, Placebo - Type 2 Diabetes | Phase 4 | Completed | Pennington Biomedical Research Center | 100 | 2003-10-01 | 2016-04-08 |
| Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholesterol Control in T2DM Chromium Picolinate (600 mcg Cr) + biotin (2 mg) - Diabetes Mellitus, Type 2 | Not applicable | Completed | Nutrition 21, Inc. | 600 | 2003-03-01 | 2006-02-09 |
| Chromium and Insulin Action Chromium Picolinate - Type 2 Diabetes | Phase 4 | Completed | Pennington Biomedical Research Center | 30 | 1998-08-01 | 2016-04-08 |
Insulin Resistance (7) · Diabetes Mellitus, Type 2 (5) · Obesity (3) · Acanthosis Nigricans (1) · Acquired Immunodeficiency Syndrome (1) · Asthma (1) · Binge-Eating Disorder (1) · Bipolar Disorder (1) · Body Weight (1) · Bulimia (1) · COVID-19 (1) · Depressive Disorder, Major (1) · Diabetes Mellitus (1) · HIV Infections (1) · Hyaline Membrane Disease (1)
Pennington Biomedical Research Center (3) · National Center for Complementary and Integrative Health (NCCIH) (2) · Nutrition 21, Inc. (2) · Stony Brook University (2) · Universitas Indonesia (2) · Bastyr University (1) · Cairo University (1) · Fayoum University (1) · Hucircadian (1) · Swedish Medical Center (1) · University of Jordan (1) · University of New Mexico (1) · University of North Carolina, Chapel Hill (1) · Uruk University (1)
United States (11) · Egypt (1) · Indonesia (1) · Iraq (1) · Jordan (1) · South Korea (1)
William Cefalu, MD (2) · Atef M Sayed, MD (1) · Cesar Albarracin, MD (1) · Ghasak Kais Abdulhussain, BSc, MSc, PhD (Pharmacology) (1) · Hank Kaplan, MD (1) · Jeffery Geohas, MD (1) · Kimberly A Brownley, PhD (1) · Manley R Finch (1) · Marie C Gelato, MD, PhD (1) · Marie C. Gelato, MD, PhD (1) · Mohamed A Hamed, MD (1) · Nayyar Iqbal, MD (1) · Ryan Bradley, ND (1) · Stephen D Anton, Ph.D. (1) · Yuyun Lisnawati (1)
PMID 17684468, PMID 19422140, PMID 20022616, PMID 23751236, PMID 25346863, PMID 29307520, PMID 39086163