3 completed, 3 recruiting, 2 active not recruiting. 2 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 2 | Completed 1, Recruiting 1 |
| Phase 2 | 2 | Active not recruiting 1, Recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow Hippocampal Sclerosis: new trials by email Literature Review of Hippocampal Sclerosis trials Research Report on Hippocampal Sclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cartography of Social Cognition Network and Their Alterations in Patients With Epilepsy MRI 3T and MRI 7T - Epilepsy, Drug Resistant Epilepsy | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 20 | 2025-03-19 | 2025-03-21 |
| Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach Amygdalo-Hippocampectomy - Hippocampal Sclerosis, Dysembryoplastic Neuroepithelial Tumor | Recruiting | University Hospital, Montpellier | 3504 | 2024-08-31 | 2025-04-08 | |
| AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy AAV9-hSyn1-miGRIK2 - Mesial Temporal Lobe Epilepsy | Phase 1 / Phase 2 | Recruiting | UniQure Biopharma B.V. | 12 | 2024-06-12 | 2026-08-24 |
| Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging Nicorandil, Placebo - Dementia, Mild Cognitive Impairment | Phase 2 | Active not recruiting | Gregory Jicha, MD, PhD | 64 | 2021-12-01 | 2025-12-15 |
| Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis RNA sequencing - Epilepsy, Hippocampal Sclerosis | Active not recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 10 | 2021-04-19 | 2026-04-27 | |
| Hippocampal Sclerosis and Amnesia Not Due to Alzheimer's Disease Neurological examinations, Neuropsychological examinations, Clinical examinations - Patients With Cognitive Disturbances | Not applicable | Completed | Centre Hospitalier St Anne | 141 | 2016-01-27 | 2024-07-12 |
| Herpes Virus-6 and Epilepsy Epilepsy | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 45 | 2004-06-01 | 2008-03-04 | |
| Early Surgical Intervention to Treat Epilepsy anteromesial temporal resection, antiepileptic drugs - Epilepsy, Epilepsy, Temporal Lobe | Phase 3 | Completed | University of California, Los Angeles | 200 | 2002-07-01 | 2010-02-23 |
Epilepsy (5) · Amnesia (1) · Astrocytoma (1) · Cognitive Dysfunction (1) · Dementia (1) · Drug Resistant Epilepsy (1) · Epidermal Cyst (1) · Epilepsy, Temporal Lobe (1) · Epileptic Syndromes (1) · Ganglioglioma (1) · Hamartoma (1) · Hemangioma, Capillary (1) · Malformations of Cortical Development (1) · Seizures (1)
Congenital Abnormalities (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Malformations of Cortical Development, Group I (8) · Nervous System Diseases (8) · Nervous System Malformations (8) · Malformations of Cortical Development (7) · Brain Diseases (6) · Central Nervous System Diseases (6) · Mental Disorders (2) · Neurocognitive Disorders (2) · Neurologic Manifestations (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Cognition Disorders (1) · Cysts (1)
Anticonvulsants (1) · Nicorandil (1) · Restraint, Physical (1) · Sequence Analysis, RNA (1)
Assistance Publique - Hôpitaux de Paris (1) · Centre Hospitalier St Anne (1) · Gregory Jicha, MD, PhD (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · UniQure Biopharma B.V. (1) · University Hospital, Montpellier (1) · University of California, Los Angeles (1)
United States (4) · France (3) · China (1)
Gregory A Jicha, MD, PhD (1) · Jerome Engel, Jr., M.D., Ph.D. (1)
R01AG061111 (1)