4 completed, 1 terminated, 1 unknown, 1 withdrawn. 7 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Hemorrhagic Shock: new trials by email Literature Review of Hemorrhagic Shock trials Research Report on Hemorrhagic Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock Nitroglycerin patch 5mg, placebo - Hemorrhagic Shock | Phase 2 | Unknown | Assiut University | 100 | 2016-03-01 | 2017-08-01 |
| Control of Major Bleeding After Trauma Study Type AB plasma, Crystalloid fluid (standard of care for resuscitation) - Trauma, Hemorrhagic Shock | Phase 2 | Terminated | Denver Health and Hospital Authority | 144 | 2014-04-07 | 2019-01-08 |
| Phase 2c Dose Comparison Study of MP4OX in Trauma MP4OX, Control - Trauma, Hemorrhagic Shock | Phase 2 | Withdrawn | Sangart | 2013-12-01 | 2013-10-31 | |
| Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma 0.9% Sodium Chloride 250 mL bolus, 0.9% Sodium Chloride 2000 mL bolus - Blunt Trauma, Penetrating Wound | Phase 2 | Completed | University of Washington | 192 | 2012-03-01 | 2015-01-13 |
| Vasopressin in Traumatic Hemorrhagic Shock Study Vasopressin, Saline placebo - Shock, Hypovolemia | Phase 2 / Phase 3 | Completed | Volker Wenzel | 64 | 2010-07-01 | 2014-11-05 |
| The Trauma- Formula-Driven Versus Lab-Guided Study (TRFL Study) Massive transfusion protocol, Standard of care - Hemorrhagic Shock, Trauma Coagulopathy | Phase 1 / Phase 2 | Completed | Sunnybrook Health Sciences Centre | 70 | 2009-07-01 | 2011-12-02 |
| Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock) Premarin IV, Placebo - Hemorrhagic Shock | Phase 2 | Completed | University of Texas Southwestern Medical Center | 50 | 2009-07-01 | 2020-03-19 |
Shock, Hemorrhagic (7) · Wounds and Injuries (4) · Hemostatic Disorders (2) · Acidosis, Lactic (1) · Diabetes Insipidus (1) · Hemorrhage (1) · Hypovolemia (1) · Shock (1) · Wounds, Nonpenetrating (1) · Wounds, Penetrating (1)
Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Hemorrhage (6) · Shock (6) · Cardiovascular Diseases (2) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Hemorrhagic Disorders (2) · Vascular Diseases (2) · Acid-Base Imbalance (1) · Acidosis (1) · Endocrine System Diseases (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Kidney Diseases (1)
Saline Solution (2) · Sodium Chloride (2) · Standard of Care (2) · Nitroglycerin (1) · PEG-hemoglobin (1) · Resuscitation (1) · Vasopressins (1) · maleimide-polyethylene glycol-modified hemoglobin, MP4 (1) · polynitroxylated pegylated hemoglobin (1)
Assiut University (1) · Denver Health and Hospital Authority (1) · Sangart (1) · Sunnybrook Health Sciences Centre (1) · University of Texas Southwestern Medical Center (1) · University of Washington (1) · Volker Wenzel (1)
United States (3) · Canada (2) · Germany (2) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Egypt (1) · France (1) · Israel (1) · New Zealand (1) · Norway (1) · South Africa (1) · Switzerland (1) · United Kingdom (1)
David Hoyt, MD (1) · Ernest E Moore, MD (1) · Frank V. Booth, BCh, FACS (1) · Gordon D Rubenfeld, MD, MSc (1) · Hassan Kotb, professor (1) · Homer C Tien, MD, MSc (1) · Karim Brohi, MD (1) · Myron L Weisfeldt, MD (1) · Prof. Dr. Volker Wenzel, M.Sc., M.D. (1) · Rob Schmickers (1) · Sandro B Rizoli, MD PhD (1)
PMID 22071998, PMID 23857856, PMID 25784527, PMID 25947955, PMID 26220293, PMID 30032977, PMID 31851290, PMID 40766812, PMID 40983029
U01HL077863 (1)