5 completed, 5 unknown, 4 recruiting, 3 terminated. 17 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 17 | Completed 5, Unknown 5, Recruiting 4, Terminated 3 |
| Phase 2 | 6 | Recruiting 2, Terminated 2, Unknown 2 |
Follow Hematoma: new trials by email Literature Review of Hematoma trials Research Report on Hematoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma Tranexamic acid (TXA), Placebo - Subdural Hematoma | Phase 3 | Recruiting | Unity Health Toronto | 130 | 2026-05-20 | 2026-05-29 |
| Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) Tranexamic Acid (Cyklokapron) - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Recruiting | St. Olavs Hospital | 274 | 2025-12-10 | 2026-07-17 |
| Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma. Amoxicillin + clavulanic acid, Placebo ( FE) - Chronic Subdural Hematomas | Phase 2 / Phase 3 | Recruiting | University of Rostock | 164 | 2024-09-01 | 2026-04-29 |
| Efficacy of Atorvastatin in Chronic Subdural Haematoma Atorvastatin 20mg, Placebos - Chronic Subdural Hematoma | Phase 3 | Unknown | Chinese University of Hong Kong | 690 | 2020-01-09 | 2021-11-22 |
| Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma Tranexamic Acid 500Mg Tablet, Placebo oral capsule - Hematoma, Subdural, Chronic | Phase 3 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 554 | 2018-06-19 | 2024-06-20 |
| Start or STop Anticoagulants Randomised Trial (SoSTART) Apixaban, Rivaroxaban, Edoxaban - Intracranial Hemorrhages, Intracranial Hemorrhage, Hypertensive | Phase 3 | Completed | University of Edinburgh | 203 | 2018-03-28 | 2022-04-08 |
| Tocilizumab (RoActemra) and Tranexamic Acid (Cyklokapron) Used as Adjuncts to Chronic Subdural Hematoma Surgery Tranexamic acid and Tocilizumab - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Terminated | Oslo University Hospital | 382 | 2017-11-28 | 2021-10-13 |
| Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma Tranexamic Acid 500 MG - Chronic Subdural Hematoma | Phase 3 | Unknown | Unity Health Toronto | 60 | 2017-03-06 | 2017-09-14 |
| Mgt of Chronic Subdural Hematoma Using Dexamethasone Dexamethasone, Any surgical intervention aim at treating chronic subdural hematoma - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Unknown | University of Calgary | 326 | 2016-09-17 | 2020-07-01 |
| Treatment of Chronic Subdural Hematoma by Corticosteroids Methylprednisolone, Placebo - Chronic Subdural Hematomas | Phase 3 | Completed | Rennes University Hospital | 202 | 2016-06-24 | 2020-06-09 |
| Preventive EXACYL® on Perioperative Bleeding During Orthognathism of Maxillary Surgery Tranexamic Acid, saline solution - Peri-operative Hemorrhage or Hematoma, Surgery | Phase 3 | Completed | University Hospital, Lille | 157 | 2016-01-03 | 2026-04-22 |
| Tranexamic Acid in Chronic Subdural Hematomas Tranexamic Acid, Placebo - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Unknown | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | 130 | 2015-11-01 | 2023-09-05 |
| Dexamethasone Versus Burr Hole Craniostomy for Symptomatic Chronic Subdural Hematoma Dexamethasone, Burr Hole Craniostomy - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Terminated | University of Virginia | 10 | 2014-03-01 | 2018-12-11 |
| The Effect of Subdural Drain Placement After Burr Hole Evacuation of Chronic Subdural Haematomas on Recurrence: a Prospective Randomised-controlled Multi-centre Study Silicon subdural drain placement after burr hole evacuation of chronic subdural hematoma - Chronic Subdural Hematoma, Subdural Drain | Phase 3 | Unknown | Kwong Wah Hospital | 260 | 2013-06-01 | 2013-02-07 |
| Strategy of Continued Versus Interrupted Novel Oral Anti-coagulant at Time of Device Surgery in Patients With Moderate to High Risk of Arterial Thromboembolic Events Dabigatran, Rivaroxaban, Apixaban - Hematoma | Phase 3 | Completed | Ottawa Heart Institute Research Corporation | 663 | 2013-01-01 | 2019-10-07 |
| Interest of Oral Corticosteroids in the Treatment of Chronic Subdural Hematomas oral corticosteroids, placebo - Chronic Intracranial Subdural Hematoma | Phase 3 | Terminated | University Hospital, Montpellier | 162 | 2011-07-22 | 2026-06-02 |
| Efficacy of Platelet Rich Plasma for Treatment of Muscle Rupture With Haematoma Autologous Platelet-rich plasma (PRP), Evacuation of haematoma - Muscle Injuries | Phase 3 | Completed | Institut de Terapia Regenerativa Tissular | 71 | 2009-10-01 | 2013-01-10 |
Hematoma, Subdural, Chronic (12) · Hematoma, Subdural (2) · Atrial Fibrillation (1) · Atrial Flutter (1) · Cerebral Small Vessel Diseases (1) · Intracranial Hemorrhage, Hypertensive (1) · Intracranial Hemorrhages (1) · Recurrence (1) · Retrognathia (1) · Subarachnoid Hemorrhage (1) · Wounds and Injuries (1)
Hemorrhage (17) · Pathologic Processes (17) · Pathological Conditions, Signs and Symptoms (17) · Brain Diseases (14) · Cardiovascular Diseases (14) · Central Nervous System Diseases (14) · Cerebrovascular Disorders (14) · Craniocerebral Trauma (14) · Intracranial Hemorrhage, Traumatic (14) · Nervous System Diseases (14) · Trauma, Nervous System (14) · Vascular Diseases (14) · Wounds and Injuries (14) · Intracranial Hemorrhages (13)
Tranexamic Acid (7) · Dabigatran (2) · Dexamethasone (2) · Rivaroxaban (2) · apixaban (2) · Acenocoumarol (1) · Adrenal Cortex Hormones (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Atorvastatin (1) · Calcium Dobesilate (1) · Methylprednisolone (1) · Phenindione (1) · Prednisone (1) · Saline Solution (1) · Tablets (1)
Unity Health Toronto (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Centre de recherche du Centre hospitalier universitaire de Sherbrooke (1) · Chinese University of Hong Kong (1) · Institut de Terapia Regenerativa Tissular (1) · Kwong Wah Hospital (1) · Oslo University Hospital (1) · Ottawa Heart Institute Research Corporation (1) · Rennes University Hospital (1) · St. Olavs Hospital (1) · University Hospital, Lille (1) · University Hospital, Montpellier (1) · University of Calgary (1) · University of Edinburgh (1) · University of Rostock (1)
Canada (5) · France (3) · China (1) · Germany (1) · Hong Kong (1) · India (1) · Israel (1) · Netherlands (1) · Norway (1) · Spain (1) · United Kingdom (1) · United States (1)
Chandrashekhar Gendle, MD PhD (1) · David Birnie, MD (1) · David Mathieu, M.D. (1) · Elsa Jozefowicz, MD (1) · Jeff Healey, MD (1) · Jennifer De Jong (1) · Lonjon Nicolas, MD,PhD (1) · Mattis A Madsbu, MD PhD (1) · Michael D Cusimano, MD, PhD (1) · Milo Stanisic (1) · Rustam Al-Shahi Salman, MA PhD FRCP (1)
PMID 27150916, PMID 28583162, PMID 30462279, PMID 31610718, PMID 33787345, PMID 34022170, PMID 34465477, PMID 34487722, PMID 35042560, PMID 36700520, PMID 41999149, PMID 42423601
2015 (2), 2009 (1), 2016 (1), 2017 (1)