7 recruiting, 5 not yet recruiting, 4 completed, 2 enrolling by invitation. 10 Not applicable, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Not yet recruiting 4, Recruiting 3, Completed 2, Enrolling by invitation 1 |
| Phase 3 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 4 | 2 | Completed 1, Enrolling by invitation 1 |
Follow Heart Failure and Reduced Ejection Fraction: new trials by email Literature Review of Heart Failure and Reduced Ejection Fraction trials Research Report on Heart Failure and Reduced Ejection Fraction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RELIEVE-HFrEF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure With Reduced EF Implantation of the V-Wave Interatrial shunt, Sham (no implant) - Heart Failure and Reduced Ejection Fraction, Heart Failure Chronic | Not applicable | Not yet recruiting | V-Wave Ltd | 250 | 2026-09-30 | 2026-07-10 |
| Wearable Device-Assisted Remote Management to Improve Prognosis in Patients With Acute Heart Failure Complicated by Atrial Fibrillation: WARM-HF Trial (Stage 2) wearable device based remote management (GDMT titration for HF, rhythm control and anticoagulation management for AF) - Atrial Fibrillation (AF), Heart Failure and Reduced Ejection Fraction | Not applicable | Not yet recruiting | Beijing Anzhen Hospital | 818 | 2026-09-01 | 2026-07-09 |
| Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Failure Patients With Obesity Tirzepatide, Placebo - Heart Failure and Reduced Ejection Fraction, Obesity & Overweight | Phase 3 | Not yet recruiting | Shahid Beheshti University of Medical Sciences | 60 | 2026-07-18 | 2026-08-03 |
| Comparative Effects of Different Inspiratory Muscle Training Modalities in Patients With Heart Failure. Mechanical Pressure-Threshold IMT Device, PowerBreathe KH2 Electronic IMT Device, Sub-therapeutic Mechanical IMT Device (Sham) - Heart Failure, Heart Failure and Reduced Ejection Fraction | Not applicable | Enrolling by invitation | Universidad Nacional Andres Bello | 60 | 2026-06-17 | 2026-07-07 |
| Evaluation of Accelerated Bachmann Bundle Area Pacing in Heart Failure With Reduced ejectIon Fraction Who Have electrocarDioGraphic Evidence of Interatrial Block and Indicated for Implantable Cardioverter Defibrillator BBAP on, BBAP off, RAAP - Heart Failure and Reduced Ejection Fraction | Not applicable | Not yet recruiting | Seoul National University Hospital | 120 | 2026-05-01 | 2026-04-23 |
| Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure Notification Group, No Notification Group - Iron Deficiency (ID), Heart Failure | Not applicable | Recruiting | Kaiser Permanente | 400 | 2026-04-20 | 2026-10-01 |
| Selenium Intervention Registry Randomized Trial in Heart Failure Selenium Supplement, Placebo - Heart Failure, Heart Failure and Reduced Ejection Fraction | Phase 3 | Recruiting | Skane University Hospital | 4326 | 2026-04-01 | 2026-04-22 |
| Effectiveness and Safety of Uptitration of Guideline Directed MEdical Therapy in Heart Failure With Reduced Ejection Fraction With Limited Kidney Function Assessments Blinded kidney function assessments - Heart Failure, Heart Failure and Reduced Ejection Fraction | Not applicable | Not yet recruiting | University Medical Center Groningen | 344 | 2026-04-01 | 2025-12-18 |
| PRIMA-HF: Predicting Myocardial Recovery in Heart Failure Using Cardiac Imaging HAI-HF: High Dosing vs. Standard Dosing Adenosine During Myocardial Perfusion in Heart Failure HAI-HF: Adenosine Stress [¹⁵O]H₂O PET Imaging, Two different doses of adenosine - Heart Failure and Reduced Ejection Fraction, Heart Failure | Phase 4 | Enrolling by invitation | Gødstrup Hospital | 180 | 2025-12-08 | 2025-12-26 |
| Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure Cardiac Contractility Modulation (CCM) - Heart Failure and Reduced Ejection Fraction, NYHA Class III Heart Failure | Recruiting | Impulse Dynamics | 4200 | 2025-11-18 | 2026-03-24 | |
| Comparing Three Types of Specialist Pacemakers to Improve Heart Function and Reduce Rhythm Problems in Heart Failure Biventricular pacing, Conduction system pacing, Left bundle optimised cardiac resynchronisation therapy - Heart Failure and Reduced Ejection Fraction, Dyssynchrony | Not applicable | Recruiting | Imperial College London | 60 | 2025-11-12 | 2026-02-24 |
| Biomarkers for Left Ventricular Reverse Remodeling in Heart Failure (REVERT-HF) Heart Failure, Heart Failure and Reduced Ejection Fraction | Recruiting | Ruijin Hospital Luwan Branch | 1740 | 2025-11-01 | 2026-07-14 | |
| Developing a Digital Aid to Improve ICD Decisions Online, patient-facing decision-making aid (app) with personalized risk information., Implantable Cardioverter Defibrillator (ICD), Online, patient-facing decision-making app without personalized risk information. - Heart Failure and Reduced Ejection Fraction | Not applicable | Recruiting | Stanford University | 600 | 2025-08-01 | 2026-04-27 |
| Cardiac Left Atrial Evaluation and Response in HFrEF With Sacubitril/Valsartan Sacubtril/Valsartan - Heart Failure and Reduced Ejection Fraction | Completed | Connolly Hospital Blanchardstown | 334 | 2024-11-01 | 2026-04-13 | |
| The Effect of Ozone Treatment on Coronary Flow Reserve in Patients With Heart Failure Having Reduced Ejection Fraction Ozone treatment - Heart Failure and Reduced Ejection Fraction | Not applicable | Completed | Ekrem Bilal Karaayvaz | 60 | 2024-01-14 | 2025-09-26 |
| Effects of a Transitional Care Program on Depression, Self-Efficacy, and Self-Care in Patients With Heart Failure Structured Transitional Care Program, Usual Care - Heart Failure and Reduced Ejection Fraction, Transitional Care | Not applicable | Completed | Chang Gung Memorial Hospital | 130 | 2023-07-19 | 2026-06-22 |
| Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance Cardiac MRI - Heart Failure and Reduced Ejection Fraction, Functional Mitral Regurgitation | Recruiting | Minneapolis Heart Institute Foundation | 125 | 2022-03-03 | 2025-12-23 | |
| Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction LCZ696 (sacubitril/valsartan), Enalapril, Placebo of Enalapril - Heart Failure and Reduced Ejection Fraction | Phase 4 | Completed | Novartis Pharmaceuticals | 465 | 2016-08-17 | 2021-01-05 |
Heart Failure, Systolic (18) · Heart Failure (13) · Arrhythmias, Cardiac (1) · Atrial Fibrillation (1) · Death, Sudden, Cardiac (1) · Depression (1) · Heart Failure, Diastolic (1) · Interatrial Block (1) · Iron Deficiencies (1) · Muscle Weakness (1) · Obesity (1) · Overweight (1) · Weight Loss (1)
Cardiovascular Diseases (18) · Heart Diseases (18) · Heart Failure (5) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4) · Arrhythmias, Cardiac (2) · Nutritional and Metabolic Diseases (2) · Signs and Symptoms (2) · Behavior (1) · Behavioral Symptoms (1) · Body Weight (1) · Body Weight Changes (1) · Cardiac Conduction System Disease (1) · Death (1) · Death, Sudden (1)
Valsartan (2) · Amyloid (1) · Cardiac Resynchronization Therapy (1) · Defibrillators, Implantable (1) · Echocardiography (1) · Enalapril (1) · Tirzepatide (1) · sacubitril (1) · sacubitril and valsartan sodium hydrate drug combination (1)
Beijing Anzhen Hospital (1) · Chang Gung Memorial Hospital (1) · Connolly Hospital Blanchardstown (1) · Ekrem Bilal Karaayvaz (1) · Gødstrup Hospital (1) · Imperial College London (1) · Impulse Dynamics (1) · Kaiser Permanente (1) · Minneapolis Heart Institute Foundation (1) · Novartis Pharmaceuticals (1) · Ruijin Hospital Luwan Branch (1) · Seoul National University Hospital (1) · Shahid Beheshti University of Medical Sciences (1) · Skane University Hospital (1) · Stanford University (1)
United States (5) · Chile (1) · China (1) · Denmark (1) · Ireland (1) · Italy (1) · Netherlands (1) · Norway (1) · Sweden (1) · Taiwan (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Ahran D Arnold, MBBS, BSc, MSc, MRCP, PhD (1) · Ekrem Bilal Karaayvaz (1) · Eue-Keun Choi, M.D. Ph.D. (1) · Gabriel I Garrido Cerda, PhD(c) (1) · Gregg W. Stone, MD (1) · Joann Lindenfeld, MD (1) · Michael Zile, MD (1) · Randall S Stafford, MD, PhD (1) · William T Abraham, MD (1) · Zachary I Whinnett, MBBS, BMedSci, MRCP, PhD (1)
PMID 31475296, PMID 33663237, PMID 35115085, PMID 35560696, PMID 38022415, PMID 40678912
R01HL173578 (1)