20 completed, 9 unknown, 5 terminated, 3 not yet recruiting. 13 Not applicable, 12 Phase 2, 11 Phase 3, 2 Phase 1, 1 Early Phase 1.
Follow Hand-Foot Syndrome: new trials by email Literature Review of Hand-Foot Syndrome trials Research Report on Hand-Foot Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Traditional Chinese Medicine Treatment for Capecitabine-Related Hand-Foot Syndrome Twelve-Ingredient Prepared Sichuan Aconite Hand and Foot Bath, Standard Basic Nursing Interventions - Palmar and Plantar Erythema, Numbness of the Four Limbs | Early Phase 1 | Not yet recruiting | Emeishan Hospital of Traditional Chinese Medicine | 7 | 2026-10-01 | 2026-10-20 |
| TAR-0520 Gel in Hand and Foot Syndrome TAR-0520 gel - Hand and Foot Syndrome | Phase 2 | Not yet recruiting | Tarian Pharma | 25 | 2026-03-01 | 2026-03-09 |
| Traditional Chinese Medicine Hand-Foot Soak for Chemotherapy-Induced Peripheral Neuropathy and Hand-Foot Syndrome Traditional Chinese Medicine - Patients With Solid Tumors | Not yet recruiting | Peking University Third Hospital | 300 | 2026-02-01 | 2026-01-29 | |
| Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients Blood sampling for pharmacokinetics - Solid Cancer, Gastric (Cardia, Body) Cancer | Recruiting | Erasmus Medical Center | 66 | 2025-02-18 | 2025-08-11 | |
| Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot Syndrome True electroacupuncture + True self-administered acupressure, Doctor-prescribed treatment, Sham electroacupuncture + Sham self-administered acupressure - Capecitabine, Hand-foot Syndrome | Not applicable | Recruiting | Affiliated Hospital of Qinghai University | 220 | 2024-10-08 | 2024-12-12 |
| The Efficacy and Safety of Liangxue Ointment in the Treatment of Hand-foot Syndrome Caused by VEGFR-TKI Drugs Liangxue ointment（Traditional Chinese Ointment）, Urea cream - Hand-Foot Syndrome | Not applicable | Unknown | Peking University Cancer Hospital & Institute | 220 | 2024-03-25 | 2024-09-04 |
| The Efficacy of Acupuncture and Laser Acupuncture in Treating Chemotherapy or Target Therapy-induced Hand-foot Syndrome acupuncture, laser acupuncture, Sham-laser acupuncture - Hand-Foot Syndrome | Not applicable | Unknown | China Medical University Hospital | 60 | 2023-08-01 | 2023-07-18 |
| Topical Diclofenac for Hand-Foot Syndrome Prevention in Colorectal and Gastric Cancer on Capecitabine (DICLO-HFS) Colorectal Cancer, Gastric Cancer (GC) | Completed | Gazi University | 151 | 2023-07-30 | 2025-09-17 | |
| Efficacy and Safety of Moisturising Cream With or Without Vitamin E and Urea Cream in Palmar-plantar Erythrodysesthesia Moisturising cream with vitamin E concentrate, Moisturising cream without vitamin E concentrate, Urea cream - Palmar-Plantar Erythrodysesthesia, Palmar-Plantar Erythrodysesthesia Due to Cytotoxic Therapy | Not applicable | Completed | Sarawak General Hospital | 145 | 2023-05-16 | 2026-01-14 |
| Ice Plant Intensive Cream for the Prevention of Hand-Foot Syndrome in Breast Cancer: Pilot Randomized Controlled Trial Ice Plant Intensive Cream plus Standard Care, Standard Care - Hand-Foot Syndrome, Breast Cancer | Not applicable | Completed | University Hospital Tuebingen | 15 | 2023-03-10 | 2026-05-06 |
| Efficacy of Extra Virgin Olive Oil (EVOO) Supplementation on Hand-Foot Syndrome Incidence in Patients With Capecitabine Extra Virgin Olive Oil, Olive Oil, Placebo - Hand and Foot Skin Reaction, Hand and Foot Syndrome | Not applicable | Unknown | Universitas Sriwijaya | 60 | 2023-01-01 | 2024-01-03 |
| Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With Capecitabine (CARBAMIDE®), (VOLTAREN®) Emulgel 1% - Hand and Foot Syndrome | Phase 2 | Completed | German University in Cairo | 86 | 2022-12-08 | 2024-01-03 |
| Topical Cosmetic Products for Hand and Foot Syndrome cosmetic products - Hand Foot Skin Syndrome | Completed | Dermophisiologique s.r.l | 53 | 2022-08-31 | 2024-09-19 | |
| Possible Protective Effect of Celecoxib Against Capecitabine Induced Hand and Foot Syndrome in Patients With Colorectal Cancer Celecoxib 200mg, Capecitabine-based chemotherapy - Hand and Foot Syndrome, Erythrodysesthesia Syndrome | Phase 3 | Unknown | Tanta University | 44 | 2022-04-01 | 2022-04-14 |
| Photobiomodulation Therapy in the Management of Hand-foot Syndrome and Hand-foot Skin Reaction Photobiomodulation therapy (PBMT) - Hand-foot Syndrome, Hand-foot Skin Reaction | Not applicable | Recruiting | Jessa Hospital | 40 | 2022-01-12 | 2023-06-18 |
| The Efficacy and Safety of Mecobalamin in the Prevention of Capecitabine Induced Hand Foot Syndrome Mecobalamin 5 MG Disintegrating Oral Tablet, placebo - Hand-foot Syndrome | Phase 3 | Active not recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 234 | 2022-01-01 | 2026-02-02 |
| Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome Urea cream - Hand-Foot Syndrome | Phase 2 / Phase 3 | Unknown | Mahidol University | 214 | 2021-12-20 | 2022-04-27 |
| The Preventive Effect of Chemotherapy-induced Hand-foot Syndrome Chinese traditional medicine nursing combined with case tracking management, Health Education - Cancer | Not applicable | Unknown | Peking University Third Hospital | 130 | 2021-01-01 | 2024-06-04 |
| Acetylated Natural Nucleotides in Treating Hand-foot Syndrome Gel containing Acetylated Natural Nucleotides, Vehicle Gel - Hand-foot Syndrome | Not applicable | Completed | Nan xu | 21 | 2020-11-03 | 2023-03-01 |
| Hydration Based on Thoitaine, Aloe Vera and Calendula, in the Prevention of Hand-Foot Syndrome in Patients Using Capecitabine Extremecare, Placebo - Hand-foot Syndrome | Phase 2 | Unknown | Instituto Brasileiro de Controle do Cancer | 54 | 2019-08-02 | 2021-04-06 |
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