36 completed, 23 unknown, 8 terminated, 7 not yet recruiting. 26 Phase 2, 25 Not applicable, 16 Phase 3, 12 Phase 1, 3 Early Phase 1.
Follow Drug Eruptions: new trials by email Literature Review of Drug Eruptions trials Research Report on Drug Eruptions
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis Site specific standard of care comparison - Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis | Withdrawn | Massachusetts General Hospital | 2030-01-01 | 2026-01-16 | ||
| Interest of a Targeted Therapy for the Treatment of a Severe Form of Hypersensitivity to Drug (DRESS Syndrome) Benralizumab 30 MG/ML [Fasenra], Placebo Comparator: Placebo-Control Arm 0.9% Sodium Chloride - DRESS Syndrome | Phase 2 | Not yet recruiting | University Hospital, Lille | 96 | 2027-01-06 | 2026-05-15 |
| Subconjunctival Humira for Boston Keratoprosthesis Adalimumab Injection - Penetrating Keratoplasty, Multiple Graft Failure | Phase 1 | Not yet recruiting | Massachusetts Eye and Ear Infirmary | 8 | 2026-10-01 | 2026-08-31 |
| Traditional Chinese Medicine Treatment for Capecitabine-Related Hand-Foot Syndrome Twelve-Ingredient Prepared Sichuan Aconite Hand and Foot Bath, Standard Basic Nursing Interventions - Palmar and Plantar Erythema, Numbness of the Four Limbs | Early Phase 1 | Not yet recruiting | Emeishan Hospital of Traditional Chinese Medicine | 7 | 2026-10-01 | 2026-10-20 |
| TAR-0520 Gel in Hand and Foot Syndrome TAR-0520 gel - Hand and Foot Syndrome | Phase 2 | Not yet recruiting | Tarian Pharma | 25 | 2026-03-01 | 2026-03-09 |
| Traditional Chinese Medicine Hand-Foot Soak for Chemotherapy-Induced Peripheral Neuropathy and Hand-Foot Syndrome Traditional Chinese Medicine - Patients With Solid Tumors | Not yet recruiting | Peking University Third Hospital | 300 | 2026-02-01 | 2026-01-29 | |
| HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-Effectiveness HLA-B*58:01 Genotyping, Allopurinol Tablet, Febuxostat - Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis | Phase 4 | Not yet recruiting | Haiphong University of Medicine and Pharmacy | 228 | 2026-01-20 | 2026-01-27 |
| New Therapeutic Target for Toxic Epidermal Necrolysis (TEN) Using Anti-CD38+ Monoclonal Antibodies. DARATUMUMAB (DARZALEX®) - Toxic Epidermal Necrolysis, Immunotherapy | Phase 1 / Phase 2 | Not yet recruiting | Hospices Civils de Lyon | 9 | 2025-10-29 | 2025-08-07 |
| Autologous Serum Obtained by a Closed-Circuit Collection Device Autologous Serum 20% - GVHD, Meibomian Gland Dysfunction (Disorder) | Phase 2 | Active not recruiting | GIANCARLO FATOBENE | 16 | 2025-06-20 | 2026-10-21 |
| Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients Blood sampling for pharmacokinetics - Solid Cancer, Gastric (Cardia, Body) Cancer | Recruiting | Erasmus Medical Center | 66 | 2025-02-18 | 2025-08-11 | |
| Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot Syndrome True electroacupuncture + True self-administered acupressure, Doctor-prescribed treatment, Sham electroacupuncture + Sham self-administered acupressure - Capecitabine, Hand-foot Syndrome | Not applicable | Recruiting | Affiliated Hospital of Qinghai University | 220 | 2024-10-08 | 2024-12-12 |
| Evaluating Legit.Health Plus Support for Improving Diagnosis of Generalized Pustular Psoriasis and Other Skin Conditions Among Primary Care Physicians and Dermatologists AI-based medical device for aided diagnosis in Dermatology - Pustular Psoriasis (PP), Generalized Pustular Psoriasis (GPP) | Completed | AI Labs Group S.L | 15 | 2024-06-01 | 2026-02-24 | |
| LYell SYndrome MEsenchymal Stromal Cells Treatment Adipose derived stromal cells intravenously injected - Epidermal Necrolysis, Lyell Syndrome | Phase 1 / Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 15 | 2024-04-15 | 2025-08-01 |
| The Efficacy and Safety of Liangxue Ointment in the Treatment of Hand-foot Syndrome Caused by VEGFR-TKI Drugs Liangxue ointment（Traditional Chinese Ointment）, Urea cream - Hand-Foot Syndrome | Not applicable | Unknown | Peking University Cancer Hospital & Institute | 220 | 2024-03-25 | 2024-09-04 |
| The Efficacy of Acupuncture and Laser Acupuncture in Treating Chemotherapy or Target Therapy-induced Hand-foot Syndrome acupuncture, laser acupuncture, Sham-laser acupuncture - Hand-Foot Syndrome | Not applicable | Unknown | China Medical University Hospital | 60 | 2023-08-01 | 2023-07-18 |
| Topical Diclofenac for Hand-Foot Syndrome Prevention in Colorectal and Gastric Cancer on Capecitabine (DICLO-HFS) Colorectal Cancer, Gastric Cancer (GC) | Completed | Gazi University | 151 | 2023-07-30 | 2025-09-17 | |
| Evaluation of the Efficacy and Safety of Methylprednisolone Combined With the JAK Inhibitors in the Treatment of Toxic Epidermal Necrolysis Abrocitinib, Tofacitinib - Toxic Epidermal Necrolysis | Early Phase 1 | Unknown | Peng Zhang | 30 | 2023-07-05 | 2023-11-28 |
| Efficacy and Safety of Moisturising Cream With or Without Vitamin E and Urea Cream in Palmar-plantar Erythrodysesthesia Moisturising cream with vitamin E concentrate, Moisturising cream without vitamin E concentrate, Urea cream - Palmar-Plantar Erythrodysesthesia, Palmar-Plantar Erythrodysesthesia Due to Cytotoxic Therapy | Not applicable | Completed | Sarawak General Hospital | 145 | 2023-05-16 | 2026-01-14 |
| NATIENS: Optimal Management and Mechanisms of SJS/TEN Harmonized supportive care, Etanercept 50 mg sc day 1 and day 4 - Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses | Phase 3 | Completed | Vanderbilt University Medical Center | 2 | 2023-03-21 | 2025-12-17 |
| Ice Plant Intensive Cream for the Prevention of Hand-Foot Syndrome in Breast Cancer: Pilot Randomized Controlled Trial Ice Plant Intensive Cream plus Standard Care, Standard Care - Hand-Foot Syndrome, Breast Cancer | Not applicable | Completed | University Hospital Tuebingen | 15 | 2023-03-10 | 2026-05-06 |
Showing 20 of 91. Sign in to see all of them.
Hand-Foot Syndrome (42) · Stevens-Johnson Syndrome (40) · Breast Neoplasms (9) · Drug Hypersensitivity Syndrome (7) · Colorectal Neoplasms (6) · Drug-Related Side Effects and Adverse Reactions (5) · Dry Eye Syndromes (5) · Neoplasms (5) · Pemphigoid, Benign Mucous Membrane (5) · Drug Hypersensitivity (4) · Acute Generalized Exanthematous Pustulosis (3) · Breast Neoplasms, Male (3) · Aniridia (2) · Autoimmune Diseases (2)
Chemically-Induced Disorders (91) · Dermatitis (91) · Skin and Connective Tissue Diseases (91) · Skin Diseases (90) · Drug Hypersensitivity (87) · Drug-Related Side Effects and Adverse Reactions (86) · Immune System Diseases (48) · Hypersensitivity, Delayed (47) · Hypersensitivity (46) · Erythema (41) · Mouth Diseases (41) · Skin Diseases, Vesiculobullous (41) · Stomatognathic Diseases (41) · Stomatitis (40)
Pyridoxine (4) · Infliximab (3) · Allopurinol (2) · Blood Specimen Collection (2) · Capecitabine (2) · Celecoxib (2) · Clobetasol (2) · Cyclosporine (2) · Filgrastim (2) · Prednisone (2) · Sodium Chloride (2) · lawsone (2) · tofacitinib (2) · Acupuncture Therapy (1) · Adalimumab (1)
Assistance Publique - Hôpitaux de Paris (3) · Mahidol University (3) · Massachusetts Eye and Ear Infirmary (3) · Chulalongkorn University (2) · Cyprus University of Technology (2) · Hospices Civils de Lyon (2) · Massachusetts General Hospital (2) · Peking University Third Hospital (2) · Seoul National University Hospital (2) · University Hospital, Lille (2) · AI Labs Group S.L (1) · Advancell - Advanced In Vitro Cell Technologies, S.A. (1) · Affiliated Hospital of Qinghai University (1) · Asan Medical Center (1) · Basque Health Service (1)
United States (19) · France (11) · China (8) · Spain (5) · Thailand (5) · Belgium (4) · Brazil (4) · Germany (4) · Cyprus (2) · Egypt (2) · Italy (2) · Netherlands (2) · Singapore (2) · South Korea (2) · Switzerland (2)
James Chodosh, MD, MPH (2) · Pinnita Prabhasawat, MD (2) · Aaron Sulkes, MD (1) · Alexander Navarini, MD (1) · Antonio Martorell, PhD (1) · Arturo Saavedra, MD, PhD (1) · Berna Kurt, Assistant professor (1) · Carina Koppen, MD, PhD (1) · Chang Gong (1) · Chun Bing Chen (1) · Claes H Dohlman, MD, PhD (1) · Cornelis JA Punt, Prof MD PhD (1) · Delphine Staumont-Salle, MD,PhD (1)
PMID 28715540, PMID 12558848, PMID 15161841, PMID 15287367, PMID 17885735, PMID 20625131, PMID 21940785, PMID 23569753, PMID 24021017, PMID 24656636, PMID 24795111, PMID 25293768, PMID 25592341, PMID 26297574, PMID 27106261, PMID 28383633, PMID 28476287, PMID 28564564, PMID 28587598, PMID 29037870, PMID 29095653, PMID 29478292, PMID 29756474, PMID 29800753, PMID 30204536, PMID 30346532, PMID 30539829, PMID 30782413, PMID 32597691, PMID 33227569, PMID 33538338, PMID 33626423, PMID 34734507, PMID 35655045, PMID 36054263, PMID 37075722, PMID 37086614, PMID 37678574, PMID 38754628, PMID 39962445, PMID 40935571, PMID 42623594, PMID 42741060
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