21 completed, 7 recruiting, 7 unknown, 3 withdrawn. 38 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 38 | Completed 21, Recruiting 7, Unknown 7, Withdrawn 3 |
Follow Glioblastoma Multiforme: new trials by email Literature Review of Glioblastoma Multiforme trials Research Report on Glioblastoma Multiforme
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dietary Cysteine and Methionine Deprivation (CMD) in Glioma Patients Normal diet, Cysteine/methionine deprivation (CMD) diet for 2 days, Cysteine/methionine deprivation (CMD) diet for 4 days - Glioblastoma Multiforme, Recurrent Glioma | Not applicable | Withdrawn | UNC Lineberger Comprehensive Cancer Center | 2026-05-01 | 2026-04-28 | |
| Application of FET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme [TYR-GLIO] MRI & PET fusion, MRI+T1C - Glioblastoma Multiforme | Not applicable | Recruiting | Copernicus Memorial Hospital | 189 | 2025-12-08 | 2026-04-17 |
| Low-Intensity Oscillatory Magnetic Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme (GBM) - An Exposure-time Escalation Pilot Trial Oncomagnetic device - Glioblastoma Multiforme | Not applicable | Recruiting | BioTex, Inc. | 30 | 2025-02-17 | 2026-06-02 |
| Ga-68 Prostate Specific Membrane Antigen PET/CT in Gliomas PSMA PET-CT - Glioma, Astrocytoma | Not applicable | Unknown | All India Institute of Medical Sciences, Bhubaneswar | 35 | 2024-02-01 | 2024-02-08 |
| NanoTherm In Adjuvant Therapy of Glioblastoma Multiforme NanoTherm therapy, Glioma Resection, radiotherapy according to Stupp protocol - Glioblastoma Multiforme | Not applicable | Recruiting | Poznan University of Medical Sciences | 100 | 2024-01-01 | 2024-02-26 |
| Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB) - Glioma, Malignant, Glioblastoma | Not applicable | Recruiting | Northwell Health | 32 | 2023-06-29 | 2026-06-01 |
| Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) Laparoscopically harvested omental tissue autograft - Glioma, Glioma, Malignant | Not applicable | Recruiting | Northwell Health | 10 | 2023-04-04 | 2026-06-01 |
| Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma Sonobiopsy, Research blood, Cancer Personalized Profiling - Glioblastoma, Glioblastoma Multiforme | Not applicable | Recruiting | Washington University School of Medicine | 40 | 2022-04-18 | 2026-05-14 |
| UNIty-Based MR-Linac Guided AdapTive RadiothErapy for High GraDe Glioma: a Phase 2 Trial Reduced margin adaptive radiotherapy - Glioblastoma Multiforme | Not applicable | Completed | Sunnybrook Health Sciences Centre | 108 | 2021-03-29 | 2024-11-29 |
| Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM Optune® - Glioblastoma Multiforme | Not applicable | Completed | NovoCure Ltd. | 981 | 2020-12-08 | 2026-10-05 |
| Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma Amantadine Hydrochloride - Glioblastoma Multiforme | Not applicable | Unknown | CancerCare Manitoba | 20 | 2020-12-02 | 2024-02-23 |
| Efficacy and Safety of NaviFUS System add-on Bevacizumab (BEV) in Recurrent GBM Patients NaviFUS System, Bevacizumab - Glioblastoma Multiforme, Glioblastoma | Not applicable | Completed | NaviFUS Corporation | 6 | 2020-07-21 | 2026-04-09 |
| 18F-PSMA PET/CT for Visualization of Glioblastoma Multiforme 18F-PSMA-1007 PET tracer - Glioblastoma Multiforme | Not applicable | Unknown | Radboud University Medical Center | 5 | 2020-01-17 | 2021-01-27 |
| The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients. Awake craniotomy, Craniotomy under general anesthesia - Glioblastoma, Glioblastoma Multiforme | Not applicable | Recruiting | Jasper Gerritsen | 246 | 2019-04-01 | 2023-11-21 |
| ExAblate Blood-Brain Barrier Disruption for Glioblastoma in Patients Undergoing Standard Chemotherapy BBB Disruption with Chemotherapy Arm - Glioblastoma Multiforme | Not applicable | Completed | InSightec | 9 | 2018-08-28 | 2024-03-05 |
| Safety of BBB Disruption Using NaviFUS System in Recurrent Glioblastoma Multiforme (GBM) Patients NaviFUS System - Glioblastoma Multiforme, Brain Tumor | Not applicable | Completed | NaviFUS Corporation | 6 | 2018-08-17 | 2019-06-21 |
| Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB) - Glioblastoma, Glioblastoma Multiforme | Not applicable | Completed | Northwell Health | 12 | 2018-07-27 | 2026-06-01 |
| Multi-site Validation and Application of a Consensus DSC-MRI Protocol DSC-MRI - Glioblastoma Multiforme, Gliosarcoma | Not applicable | Unknown | St. Joseph's Hospital and Medical Center, Phoenix | 80 | 2018-02-01 | 2018-01-17 |
| Nativis Voyager for Newly Diagnosed GBM Nativis Voyager - Glioblastoma Multiforme | Not applicable | Completed | Nativis, Inc. | 37 | 2017-11-10 | 2023-02-02 |
| TTFields Together With Temozolomide and Radiotherapy in Patients With Newly Diagnosed GBM NovoTTF-200A, Radiotherapy, Temozolomide - Glioblastoma Multiforme | Not applicable | Unknown | NovoCure Ltd. | 10 | 2017-04-27 | 2018-12-20 |
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Glioblastoma (38) · Brain Neoplasms (10) · Glioma (8) · Neoplasms (4) · Astrocytoma (2) · Lung Neoplasms (2) · Neoplasms, Nerve Tissue (2) · Anxiety Disorders (1) · Colonic Neoplasms (1) · Cytomegalovirus Infections (1) · Death (1) · Depression (1) · Esophageal Neoplasms (1) · Fatigue (1) · Gliosarcoma (1)
Neoplasms by Histologic Type (38) · Neoplasms, Germ Cell and Embryonal (38) · Neoplasms, Glandular and Epithelial (38) · Neoplasms, Neuroepithelial (38) · Neuroectodermal Tumors (38) · Astrocytoma (36) · Neoplasms, Nerve Tissue (36) · Neoplasms (34) · Glioma (30) · Neoplasms by Site (12) · Nervous System Diseases (11) · Brain Diseases (10) · Central Nervous System Diseases (10) · Central Nervous System Neoplasms (10) · Nervous System Neoplasms (10)
Temozolomide (2) · Acceptance and Commitment Therapy (1) · Behavior Therapy (1) · Bevacizumab (1) · Calcium Dobesilate (1) · Cognitive Behavioral Therapy (1) · Cysteine (1) · Cytidine Triphosphate (1) · Dexamethasone (1) · Diet (1) · Diet Therapy (1) · Drug Therapy (1) · Fluorescein (1) · Iodine-125 (1) · Magnetic Resonance Spectroscopy (1)
Nativis, Inc. (3) · Northwell Health (3) · NaviFUS Corporation (2) · NovoCure Ltd. (2) · Abramson Cancer Center at Penn Medicine (1) · All India Institute of Medical Sciences, Bhubaneswar (1) · Azienda USL Reggio Emilia - IRCCS (1) · BioTex, Inc. (1) · CancerCare Manitoba (1) · Copernicus Memorial Hospital (1) · Drexel University (1) · Duke University (1) · InSightec (1) · Jasper Gerritsen (1) · Karolinska Institutet (1)
United States (15) · Canada (4) · Belgium (3) · Netherlands (3) · Poland (3) · Taiwan (3) · Australia (2) · Germany (2) · Israel (2) · United Kingdom (2) · Austria (1) · Czechia (1) · France (1) · India (1) · Italy (1)
Donna Morgan Murray, PhD (3) · John Boockvar, MD (3) · Kuo-Chen Wei, M.D. (2) · Albert Kim, M.D. (1) · Arnaud Vincent, MD PhD (1) · Cecilia Soderberg-Naucler, MD, PhD (1) · Chad Quarles, PhD (1) · David R Ormond, MD (1) · Didier Martin, MD, PhD (1) · Dominique Higgins, MD, PhD (1) · Frank Giordano, MD (1) · Henk van Santbrink, MD, PhD (1) · Inti Peredo, MD (1) · Jai Shankar (1) · Jaishri O. Blakeley, MD (1)
PMID 28913154, PMID 29209515, PMID 30054634, PMID 31676314, PMID 31899873, PMID 33014832, PMID 34233941, PMID 34290067, PMID 35552391, PMID 35569489, PMID 35574391, PMID 36336899, PMID 37462385, PMID 37640160, PMID 38664311, PMID 38814627, PMID 38968568, PMID 40204663, PMID 41170811, PMID 42134380
R01CA276174 (1)