22 completed, 15 terminated, 7 active not recruiting, 7 recruiting. 21 Phase 2, 18 Not applicable, 15 Phase 1, 4 Early Phase 1, 4 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pre-operative Tumor Treating Fields in Patients With Resectable Lung Cancer NovoTTF-200T System - NSCLC, Non Small Cell Lung Cancer | Not applicable | Withdrawn | University of Texas Southwestern Medical Center | 2026-10-01 | 2026-10-23 | |
| NovoTTF-200A + Pembrolizumab In Melanoma Brain Metastasis NovoTTF-200A, Pembrolizumab - Metastatic Melanoma, Melanoma Brain Metastasis | Phase 1 / Phase 2 | Withdrawn | Brown University | 2025-10-30 | 2026-01-02 | |
| A Phase I Study of the NovoTTF-200M and Novo TTF-200A Systems for the Treatment of Refractory Spinal Metastasis TTF-200M and TTF-200A systems - Spinal Metastasis | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 30 | 2025-08-18 | 2026-10-06 |
| Preoperative Preradiotherapy TTFields TTFields - Glioblastoma | Not applicable | Recruiting | The Christie NHS Foundation Trust | 42 | 2024-12-19 | 2026-05-08 |
| Study of Biologic Tumor and Plasma Biomarkers of Response to TTFields in Patients Treated for Newly Diagnosed Glioblastoma The samples described below will be collected: - Glioblastoma | Not applicable | Recruiting | Institut Claudius Regaud | 80 | 2024-08-27 | 2026-02-13 |
| TTFields General Routine Clinical Care in ndGBM Patients: a French Prospective Non-Interventional Study (TIGER France) Glioblastoma | Recruiting | NovoCure Ltd. | 430 | 2024-01-11 | 2025-04-11 | |
| Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer Stereotactic Ablative Body Radiation (SABR), Tumor Treating Fields (TTF) - Pancreas Cancer, Locally Advanced | Not applicable | Recruiting | Baptist Health South Florida | 48 | 2023-09-21 | 2026-01-12 |
| EF-39 PANOVA-4: Study of Tumor Treating Fields Concomitant With Atezolizumab, Gemcitabine and Nab-Paclitaxel as First-LineTreatment for Metastatic Pancreatic Ductal Adenocarcinoma Tumor Treating Fields, Atezolizumab, Gemcitabine - Metastatic Pancreatic Ductal Adenocarcinoma | Phase 2 | Completed | NovoCure Ltd. | 84 | 2023-08-21 | 2026-09-04 |
| A Study of Tumor-Treating Fields (TTFields) in People With Lung Adenocarcinoma NovoTTF-200T System - Adenocarcinoma of Lung | Phase 1 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 12 | 2023-08-04 | 2026-05-28 |
| TTFields in General Routine Clinical Care in Patients With Pleural Mesothelioma Study TTFields - Pleural Mesothelioma | Recruiting | NovoCure Ltd. | 198 | 2023-08-01 | 2025-08-22 | |
| WBSI Guided Personalized Delivery of TTFields Whole Brain Spectroscopy Imaging Array Mapping Layout - GBM, Glioma Glioblastoma Multiforme | Not applicable | Recruiting | Abramson Cancer Center at Penn Medicine | 155 | 2023-01-15 | 2026-08-06 |
| Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases Ipilimumab, Nivolumab, Pembrolizumab - Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary | Phase 1 | Terminated | Emory University | 1 | 2022-10-13 | 2026-04-23 |
| Nab-Paclitaxel + Cisplatin + Gemcitabine + TTF in pt. w/ Metastatic PAC Modified GCN+TTF treatment - Pancreas Cancer, Metastatic Pancreatic Cancer | Phase 1 / Phase 2 | Active not recruiting | Mayo Clinic | 40 | 2022-04-25 | 2026-09-29 |
| Single Arm Trial of Tumor-Treating Fields in Combination With Nivolumab and Ipilimumab in Metastatic Uveal Melanoma Novocure Optune, Opdivo, Yervoy - Uveal Melanoma | Phase 1 | Completed | HonorHealth Research Institute | 10 | 2022-02-28 | 2025-08-15 |
| TIGER PRO-Active - Daily Activity, Sleep and Neurocognitive Functioning Study TTFields - Glioblastoma | Unknown | NovoCure Ltd. | 500 | 2021-12-30 | 2023-01-10 | |
| Study of Tumor Treating Fields With Hypofractionated Chemoradiotherapy in Newly Diagnosed Glioblastoma Optune, Gadolinium, Temozolomide - Glioblastoma, Newly Diagnosed Glioblastoma | Phase 1 | Completed | Stanford University | 12 | 2021-05-21 | 2025-12-26 |
| Dielectric Properties of Matched Tissue Samples From Thoracic Malignancies and Corresponding Normal Tissues LCR Meter (Brand: Keysight, Serial Number:E498AL) - Lung Cancer, Esophageal Cancer | Not applicable | Unknown | University of Maryland, Baltimore | 30 | 2021-03-01 | 2021-03-18 |
| Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM Optune® - Glioblastoma Multiforme | Not applicable | Completed | NovoCure Ltd. | 981 | 2020-12-08 | 2026-10-05 |
| Anti-Cancer Effects of Carvedilol With Standard Treatment in Glioblastoma and Response of Peripheral Glioma Circulating Tumor Cells Carvedilol - Glioblastoma, Glioblastoma Multiforme | Early Phase 1 | Withdrawn | West Virginia University | 2020-09-01 | 2021-04-12 | |
| Use of Optune TTF With Radiation as an Alternative for Elderly Patients With Primary CNS Lymphoma Optune TTF device - Central Nervous System Neoplasms, Primary | Not applicable | Withdrawn | Saint Luke's Health System | 2020-08-31 | 2020-09-02 |
Showing 20 of 64. Sign in to see all of them.
Glioblastoma (29) · Brain Neoplasms (16) · Glioma (6) · Pancreatic Neoplasms (4) · Astrocytoma (3) · Carcinoma, Non-Small-Cell Lung (3) · Neoplasms (3) · Ependymoma (2) · Gliosarcoma (2) · Lung Neoplasms (2) · Melanoma (2) · Meningioma (2) · Mesothelioma, Malignant (2) · Ovarian Neoplasms (2) · Recurrence (2)
Temozolomide (9) · Bevacizumab (6) · Nivolumab (5) · Ipilimumab (4) · Gemcitabine (3) · Radiosurgery (3) · Radiotherapy (3) · pembrolizumab (3) · 130-nm albumin-bound paclitaxel (2) · Albumin-Bound Paclitaxel (2) · Oxaliplatin (2) · Paclitaxel (2) · CTLA-4 Antigen (1) · Capecitabine (1) · Carboplatin (1)
United States (46) · Germany (12) · France (9) · Spain (9) · Switzerland (9) · Czechia (8) · Italy (7) · Israel (6) · Austria (5) · Belgium (5) · Poland (5) · Canada (4) · Netherlands (3) · Hong Kong (2) · Hungary (2)
Roger Stupp, MD (2) · Adilia Hormigo, MD, PhD (1) · Albert Attia, MD (1) · Anders R Korshoej, MD (1) · Andrea Salamaggi, MD (1) · Ashley Ghiaseddin, MD (1) · Ashley Sumrall, MD (1) · Carmen Guillen, MD (1) · Claudio Tatsui, MD (1) · Cristina Sessa, MD (1) · Csaba Juhasz, MD, PhD (1) · Daniela Bota, MD (1) · David D Tran, MD, PhD (1) · David Peereboom, MD (1) · David Tran, M.D., Ph.D. (1)
PMID 35574391, PMID 22608262, PMID 26670971, PMID 27799506, PMID 28399638, PMID 29260225, PMID 29392280, PMID 30506499, PMID 30641498, PMID 31026557, PMID 31628016, PMID 32020470, PMID 32206976, PMID 34692470, PMID 36239858, PMID 36336899, PMID 36355259, PMID 40448572, PMID 40466642
P30CA014089 (1), P30CA060553 (1), P30CA093373 (1), P30CA138292 (1), R01CA262584 (1), UM1CA081457 (1)