7 completed, 3 not yet recruiting, 2 unknown, 1 active not recruiting. 7 Phase 2, 3 Phase 3, 2 Not applicable, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Not yet recruiting 3 |
| Phase 3 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Not applicable | 2 | Active not recruiting 1, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
Follow Iodine-125: new trials by email Literature Review of Iodine-125 trials Research Report on Iodine-125
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SEED-CRYO: Sequential 125I Seed Implantation Followed by Cryoablation vs Single-Modality Local Therapy in Unresectable Solid Tumors Iodine-125 (125I) Seed Implantation, cryoablation, Sequential 125I Seed Implantation Followed by Cryoablation - Unresectable Solid Tumors | Phase 2 | Not yet recruiting | Li Min | 150 | 2026-02-01 | 2026-03-04 |
| Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease Iodine-125 (125I) Seed Implantation (Low-Dose-Rate Brachytherapy), cryoablation, Lesion Allocation and Tumor Zoning Strategy - High-Burden Metastatic Solid Tumors | Phase 2 | Not yet recruiting | Li Min | 90 | 2026-02-01 | 2026-02-27 |
| Image-Guided 125I Seed Implantation Plus Standard Systemic Therapy for Patients With Multiple Metastatic Lesions Standard-of-Care Systemic Therapy, Iodine-125 (125I) Seed Implantation - Metastatic Solid Tumors | Phase 2 | Not yet recruiting | Li Min | 120 | 2026-01-01 | 2026-01-12 |
| Prostate Interstitial Brachytherapy With I125 Implant With Target Dose Supplementation in the Tumor Volume Guided by TRINITY® PERINE 3D System Interstitial Brachytherapy of the Prostate With Iodine 125 Implant With Target Dose Supplementation in the Tumor Volume Guided by the TRINITY® PERINE 3D - Prostate Cancer | Not applicable | Active not recruiting | University Hospital, Grenoble | 15 | 2023-04-04 | 2026-05-01 |
| Refractory Ascitis Diagnosis by the Study of Labelled Albumin Pharmacokinetics labelled human serumalbumin (125-I, Séralb®CisBio), labelled albumin (99m-Tc, Vasculocis®, Cisbio) - Refractory Ascites in Patients With Cirrhosis | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 30 | 2017-09-01 | 2017-06-15 |
| Surgery With or Without Internal Radiation Therapy Compared With Stereotactic Body Radiation Therapy in Treating Patients With High-Risk Stage I Non-Small Cell Lung Cancer therapeutic conventional surgery, iodine I 125, stereotactic body radiation therapy - Lung Cancer | Phase 3 | Terminated | Alliance for Clinical Trials in Oncology | 13 | 2011-05-01 | 2017-05-30 |
| Access Protocol for MAB-425 Radiolabeled With I-125 for High Grade Gliomas MAB-425 radiolabeled with I-125 - Glioblastoma Multiforme, Astrocytoma Anaplastic Foci | Not applicable | Unknown | Drexel University | 11 | 2010-01-01 | 2011-03-17 |
| Ultrasound-Guided Implant Radiation Therapy in Treating Patients With Locally Recurrent Prostate Cancer Previously Treated With External-Beam Radiation Therapy 125-Iodine, 103-palladium - Prostate Cancer | Phase 2 | Completed | Radiation Therapy Oncology Group | 100 | 2007-05-01 | 2022-06-21 |
| Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma Carboplatin, Cryosurgery, Infrared Laser Therapy - Intraocular Retinoblastoma | Phase 3 | Completed | Children's Oncology Group | 28 | 2005-12-26 | 2023-03-13 |
| Brachytherapy in Treating Patients With Recurrent Malignant Glioma adjuvant therapy, iodine I 125 - Brain and Central Nervous System Tumors | Phase 1 | Completed | National Cancer Institute (NCI) | 2002-10-01 | 2009-02-09 | |
| External-Beam Radiation Therapy Plus Implanted Radiation Therapy in Treating Patients With Prostate Cancer brachytherapy, iodine I 125, radiation therapy - Prostate Cancer | Phase 2 | Completed | Radiation Therapy Oncology Group | 138 | 2000-11-01 | 2020-10-22 |
| Internal Radiation Therapy Plus Carmustine Implants in Treating Patients With Recurrent or Refractory Malignant Glioma polifeprosan 20 with carmustine implant, surgical procedure, iodine I 125 - Brain and Central Nervous System Tumors | Phase 1 | Completed | Barrett Cancer Center | 1999-04-01 | 2013-06-26 | |
| Radiation Therapy in Treating Patients With Progressive or Recurrent Malignant Brain Tumors surgical procedure, brachytherapy, intraoperative radiation therapy - Brain and Central Nervous System Tumors | Phase 2 | Completed | New Approaches to Brain Tumor Therapy Consortium | 1999-04-01 | 2013-06-21 | |
| Brachytherapy in Treating Patients With Prostate Cancer iodine I 125 - Prostate Cancer | Phase 2 | Completed | Radiation Therapy Oncology Group | 95 | 1998-09-01 | 2014-01-24 |
Glioblastoma (4) · Prostatic Neoplasms (4) · Astrocytoma (3) · Brain Neoplasms (3) · Central Nervous System Neoplasms (3) · Gliosarcoma (3) · Oligodendroglioma (3) · Ascites (1) · Carcinoma, Non-Small-Cell Lung (1) · Glioma (1) · Lung Neoplasms (1)
Li Min (3) · Radiation Therapy Oncology Group (3) · Alliance for Clinical Trials in Oncology (1) · Assistance Publique - Hôpitaux de Paris (1) · Barrett Cancer Center (1) · Children's Oncology Group (1) · Drexel University (1) · National Cancer Institute (NCI) (1) · New Approaches to Brain Tumor Therapy Consortium (1) · University Hospital, Grenoble (1)
United States (8) · Canada (4) · China (3) · France (2)
Min Li (2) · Carole Iriard, MD (1) · Colleen A. Lawton, MD (1) · Debra L Friedman (1) · Hiran C. Fernando, MD (1) · Juanita M. Crook, MD (1) · Larry Kleinberg, MD (1) · Robert E. Albright, MD (1) · Stephen Tatter, MD, PhD (1) · W. Robert Lee, MD (1)
PMID 15989995, PMID 16289906, PMID 17084551, PMID 17118317, PMID 17340591, PMID 21470793, PMID 22330999, PMID 22795435, PMID 30312717, PMID 34740768
2015 (1), U10CA076001 (1), U10CA098543 (1)