14 terminated. 14 Phase 2, 5 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Terminated 14 |
| Phase 1 | 5 | Terminated 5 |
| Phase 3 | 2 | Terminated 2 |
Follow Fibrosarcoma: new trials by email Literature Review of Fibrosarcoma trials Research Report on Fibrosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors TNG908 - Locally Advanced Solid Tumor | Phase 1 / Phase 2 | Terminated | Tango Therapeutics, Inc. | 110 | 2022-03-23 | 2026-04-15 |
| A Clinical Trial to Evaluate the Safety and Efficacy of AL2846 Capsules in Chinese Patients With Type I Neurofibromatosis AL2846 capsules - Neurofibromatosis and Malignant Peripheral Nerve Sheath Tumors | Phase 1 / Phase 2 | Terminated | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 22 | 2021-09-07 | 2024-03-21 |
| A Study to Learn About the Study Medicine (Called Ontorpacept or TTI-621) Given Alone and in Combination With Doxorubicin in People With Leiomyosarcoma Ontorpacept (TTI-621), Doxorubicin - Leiomyosarcoma | Phase 2 | Terminated | Pfizer | 76 | 2021-06-22 | 2024-12-11 |
| Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Etoposide - Desmoplastic Small Round Cell Tumor, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Phase 2 | Terminated | M.D. Anderson Cancer Center | 1 | 2020-08-19 | 2025-06-29 |
| A Study of Pembrolizumab in Patients With Malignant Peripheral Nerve Sheath Tumor (MPNST), Not Eligible for Curative Surgery Pembrolizumab - Malignant Peripheral Nerve Sheath Tumour (MPNST) | Phase 2 | Terminated | Oslo University Hospital | 8 | 2016-06-01 | 2021-06-23 |
| Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma Pazopanib, Pazopanib Hydrochloride, Sapanisertib - High Grade Sarcoma, Metastatic Leiomyosarcoma | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 151 | 2015-11-30 | 2022-08-23 |
| PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors PLX3397, sirolimus - Sarcoma, Malignant Peripheral Nerve Sheath Tumors | Phase 1 / Phase 2 | Terminated | Gulam Manji | 39 | 2015-11-04 | 2025-03-21 |
| Gemcitabine and Docetaxel in Combination With Pazopanib (Gem/Doce/Pzb) for the Neoadjuvant Treatment of Soft Tissue Sarcoma (STS) Pazopanib 400 mg QD - Gemcitabine and Docetaxel in Combination - Sarcoma, Leiomyosarcoma | Phase 1 / Phase 2 | Terminated | Memorial Sloan Kettering Cancer Center | 5 | 2011-08-01 | 2018-01-11 |
| Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma doxorubicin hydrochloride, trabectedin, laboratory biomarker analysis - Sarcoma | Phase 2 / Phase 3 | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 133 | 2011-05-01 | 2014-08-08 |
| Phase II Pazopanib Study in Advanced Dermatofibrosarcomas Pazopanib - Dermatofibrosarcomas of DARIER FERRAND(DFSP) | Phase 2 | Terminated | Assistance Publique - Hôpitaux de Paris | 23 | 2010-07-01 | 2016-07-01 |
| Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma gene expression analysis, polymerase chain reaction, western blotting - Sarcoma | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2008-07-01 | 2014-07-11 |
| Imatinib Mesylate Treatment of Patients With Malignant Peripheral Nerve Sheath Tumors imatinib mesylate - Malignant Peripheral Nerve Sheath Tumors | Phase 2 / Phase 3 | Terminated | Novartis Pharmaceuticals | 11 | 2006-05-01 | 2012-08-07 |
| Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood Fibrosarcoma dactinomycin, cyclophosphamide, etoposide - Sarcoma | Phase 2 | Terminated | Children's Oncology Group | 7 | 2004-11-01 | 2014-09-30 |
| S9624 Ifosfamide in Treating Patients With Meningeal Tumors ifosfamide - Chondrosarcoma, Adult Fibrosarcoma | Phase 2 | Terminated | SWOG Cancer Research Network | 7 | 1998-07-01 | 2013-11-08 |
Neurofibrosarcoma (10) · Sarcoma (7) · Leiomyosarcoma (5) · Dermatofibrosarcoma (4) · Histiocytoma, Malignant Fibrous (4) · Rhabdomyosarcoma (3) · Chondrosarcoma, Extraskeletal Myxoid (2) · Desmoplastic Small Round Cell Tumor (2) · Hemangiopericytoma, Malignant (2) · Hemangiosarcoma (2) · Malignant mesenchymal tumor (2) · Neurofibromatoses (2) · Sarcoma, Alveolar Soft Part (2) · Sarcoma, Synovial (2)
Neoplasms (14) · Neoplasms by Histologic Type (14) · Neoplasms, Connective Tissue (14) · Neoplasms, Connective and Soft Tissue (14) · Neoplasms, Fibrous Tissue (14) · Neoplasms, Nerve Tissue (11) · Nervous System Diseases (11) · Nervous System Neoplasms (11) · Neurofibroma (10) · Neuromuscular Diseases (10) · Peripheral Nervous System Diseases (10) · Peripheral Nervous System Neoplasms (10) · Nerve Sheath Neoplasms (9) · Neoplasms, Muscle Tissue (7)
pazopanib (3) · Doxorubicin (2) · Etoposide (2) · Ifosfamide (2) · Antilymphocyte Serum (1) · Blotting, Western (1) · Cyclophosphamide (1) · Cyclosporine (1) · Cyclosporins (1) · Dactinomycin (1) · Docetaxel (1) · Filgrastim (1) · Gene Expression Profiling (1) · Granulocyte Colony-Stimulating Factor (1) · Imatinib Mesylate (1)
Assistance Publique - Hôpitaux de Paris (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Children's Oncology Group (1) · City of Hope Medical Center (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Gulam Manji (1) · M.D. Anderson Cancer Center (1) · Memorial Sloan Kettering Cancer Center (1) · National Cancer Institute (NCI) (1) · Novartis Pharmaceuticals (1) · Oslo University Hospital (1) · Pfizer (1) · SWOG Cancer Research Network (1) · Tango Therapeutics, Inc. (1)
United States (10) · France (3) · Australia (2) · Germany (2) · Austria (1) · Belgium (1) · Canada (1) · China (1) · Denmark (1) · Hungary (1) · Netherlands (1) · New Zealand (1) · Norway (1) · Peru (1) · Poland (1)
Anne B. Warwick, MD, MPH (1) · Gulam A. Manji, MD (1) · James E. Butrynski, MD (1) · Jeremy S Connors, MD (1) · Leslie McAllister, MD (1) · Lynn G. Feun, MD (1) · Maxim Pimkin, MD, PhD (1) · Mignon Loh, MD (1) · Nguyen Binh Bui, MD (1) · Richard D. Pezner, MD (1) · Tormod K Guren, MD, PhD (1) · William D Tap (1)
PMID 32956651, PMID 34321280, PMID 39756156
2009 (2), P30CA033572 (1), U10CA032102 (1), U10CA180821 (1)