22 completed. 22 Phase 1, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 22 |
| Phase 2 | 8 | Completed 8 |
Follow Fibrosarcoma: new trials by email Literature Review of Fibrosarcoma trials Research Report on Fibrosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients Selinexor - Soft Tissue Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST) | Phase 1 | Completed | University Health Network, Toronto | 56 | 2021-03-29 | 2025-05-29 |
| Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas DCC-3014, Avelumab - Sarcoma, Advanced Sarcoma | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 32 | 2020-01-22 | 2025-08-28 |
| CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma CAB-AXL-ADC, PD-1 inhibitor - Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma | Phase 1 / Phase 2 | Completed | BioAtla, Inc. | 245 | 2018-02-15 | 2025-09-23 |
| Vaccine Therapy in Treating Patients with Malignant Peripheral Nerve Sheath Tumor That is Recurrent or Cannot Be Removed by Surgery Computed Tomography, Laboratory Biomarker Analysis, Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter - Metastatic Malignant Peripheral Nerve Sheath Tumor, Neurofibromatosis Type 1 | Phase 1 | Completed | Mayo Clinic | 9 | 2017-03-22 | 2024-09-27 |
| Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Doxorubicin Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study - Advanced Soft Tissue Sarcoma, Locally Advanced Angiosarcoma | Phase 1 | Completed | OHSU Knight Cancer Institute | 16 | 2017-03-10 | 2023-08-16 |
| Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 MRI, FDG-PET/CT scans, [18F]-FLT-PET/CT scans - Neurofibromatosis, MPNST | Phase 1 | Completed | National Cancer Institute (NCI) | 10 | 2014-12-08 | 2026-10-29 |
| Study to Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors nab-paclitaxel - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Completed | Celgene | 107 | 2013-12-04 | 2019-12-27 |
| SARC023: Ganetespib and Sirolimus in Patients With MPNST (Malignant Peripheral Nerve Sheath Tumors) ganetespib, Sirolimus - Malignant Peripheral Nerve Sheath Tumors (MPNST), Sarcoma | Phase 1 / Phase 2 | Completed | Sarcoma Alliance for Research through Collaboration | 20 | 2013-12-01 | 2019-05-15 |
| Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors in Pediatric Patients Recombinant Vaccinia GM-CSF; RAC VAC GM-CSF (JX-594) - Neuroblastoma, Rhabdomyosarcoma | Phase 1 | Completed | Jennerex Biotherapeutics | 6 | 2010-08-01 | 2016-01-21 |
| Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Gamma-Secretase Inhibitor RO4929097, Laboratory Biomarker Analysis, Pharmacological Study - Adult Alveolar Soft Part Sarcoma, Adult Angiosarcoma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 78 | 2010-06-01 | 2018-08-15 |
| HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors HSV1716 - Rhabdomyosarcoma, Osteosarcoma | Phase 1 | Completed | Timothy Cripe | 18 | 2010-03-01 | 2018-03-21 |
| Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma temsirolimus plus liposomal doxorubicin - Sarcoma | Phase 1 / Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 24 | 2009-09-01 | 2019-03-11 |
| Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib Mesylate Imatinib mesylate, Cyclophosphamide (Dosing level 1 ), Imatinib mesylate, Cyclophosphamide (Dosing level 2), Imatinib mesylate, Cyclophosphamide (Dosing level 3) - Cancer | Phase 1 | Completed | Centre Oscar Lambret | 26 | 2009-02-09 | 2026-09-17 |
| Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Cixutumumab, Doxorubicin Hydrochloride, Laboratory Biomarker Analysis - Adult Angiosarcoma, Adult Desmoplastic Small Round Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2008-06-01 | 2016-05-17 |
| Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma oral belinostat - Solid Tumor, Lymphoma | Phase 1 | Completed | Valerio Therapeutics | 121 | 2006-06-01 | 2015-07-08 |
| Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors belinostat, 5-Fluorouracil (5-FU) - Tumor | Phase 1 | Completed | Valerio Therapeutics | 35 | 2005-09-01 | 2015-07-08 |
| Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery celecoxib, adjuvant therapy, radiation therapy - Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma | Phase 1 | Completed | University of Miami | 3 | 2004-03-01 | 2016-12-15 |
| Imatinib in Dermatofibrosarcoma Protuberans (DFSP) Imatinib (Glivec) - Dermatofibrosarcoma | Phase 1 / Phase 2 | Completed | Dermatologic Cooperative Oncology Group | 30 | 2004-01-01 | 2011-07-29 |
| Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma ifosfamide, pegylated liposomal doxorubicin hydrochloride - Sarcoma | Phase 1 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 28 | 2001-11-01 | 2012-09-24 |
| STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma imatinib mesylate - Endometrial Cancer, Gastrointestinal Stromal Tumor | Phase 1 / Phase 2 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 91 | 2000-08-01 | 2012-09-24 |
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Sarcoma (16) · Neurofibrosarcoma (14) · Histiocytoma, Malignant Fibrous (10) · Leiomyosarcoma (10) · Liposarcoma (10) · Rhabdomyosarcoma (9) · Dermatofibrosarcoma (8) · Hemangiosarcoma (8) · Sarcoma, Synovial (8) · Osteosarcoma (7) · Chondrosarcoma (5) · Neoplasms (5) · Sarcoma, Ewing (5) · Hemangiopericytoma, Malignant (4)
Neoplasms by Histologic Type (22) · Neoplasms, Connective Tissue (22) · Neoplasms, Connective and Soft Tissue (22) · Neoplasms, Fibrous Tissue (22) · Neoplasms (17) · Neoplasms, Nerve Tissue (16) · Neoplasms, Muscle Tissue (14) · Nerve Sheath Neoplasms (14) · Nervous System Diseases (14) · Nervous System Neoplasms (14) · Neurofibroma (14) · Neuromuscular Diseases (14) · Peripheral Nervous System Diseases (14) · Peripheral Nervous System Neoplasms (14)
Imatinib Mesylate (3) · Doxorubicin (2) · Magnetic Resonance Spectroscopy (2) · belinostat (2) · 130-nm albumin-bound paclitaxel (1) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · Albumin-Bound Paclitaxel (1) · Biopsy (1) · Blood Specimen Collection (1) · Celecoxib (1) · Chemotherapy, Adjuvant (1) · Cyclophosphamide (1) · Estramustine (1) · Filgrastim (1) · Fluorouracil (1)
National Cancer Institute (NCI) (4) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Valerio Therapeutics (2) · BioAtla, Inc. (1) · Celgene (1) · Centre Oscar Lambret (1) · Dermatologic Cooperative Oncology Group (1) · Jennerex Biotherapeutics (1) · Mayo Clinic (1) · Memorial Sloan Kettering Cancer Center (1) · NYU Langone Health (1) · OHSU Knight Cancer Institute (1) · Sarcoma Alliance for Research through Collaboration (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Timothy Cripe (1)
United States (17) · Denmark (3) · France (3) · United Kingdom (3) · Canada (2) · Germany (2) · Belgium (1) · Hong Kong (1) · Italy (1) · Netherlands (1) · Spain (1) · Switzerland (1) · Taiwan (1)
Aaron H. Wolfson, MD (1) · AeRang Kim, MD, PhD (1) · Albiruni Razak, M.D. (1) · Brigitte C Widemann, M.D. (1) · Brigitte Widemann, MD (1) · Crystal L Mackall, M.D. (1) · David M Loeb, MD, PhD (1) · Dirk Schadendorf, MD (1) · Dusica Babovic-Vuksanovic, MD (1) · Franco M. Muggia, MD (1) · Ileana Elias, M.D. (1) · Jacob Verweij, MD, PhD (1) · Lara E Davis (1) · Mrinal Gounder (1)
PMID 11705489, PMID 12528778, PMID 12957454, PMID 15010069, PMID 15592836, PMID 19088049, PMID 23382028, PMID 25858498, PMID 30410720, PMID 31401903, PMID 32089640, PMID 32554315, PMID 33641042, PMID 38579194
2008 (1), N01CM00071 (1), N01CM62206 (1), P30CA008748 (1), P30CA014599 (1), P30CA016087 (1), U01CA069856 (1)