7 completed, 5 recruiting, 4 unknown, 2 not yet recruiting. 18 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 7, Recruiting 5, Unknown 4, Not yet recruiting 2 |
| Phase 1 | 4 | Completed 2, Unknown 2 |
| Phase 3 | 1 | Completed 1 |
Follow Fasting: new trials by email Literature Review of Fasting trials Research Report on Fasting
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Targeting HealthY Eating to Maintain Energy While Living With Cancer Nutrition counseling, Time-restricted eating - Fatigue in Cancer Survivors | Phase 2 | Recruiting | University of Maryland, Baltimore | 132 | 2026-11-01 | 2026-11-03 |
| 16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal Cancer 16-Hour Fasting, Serplulimab + chemotherapy - pMMR/MSS, Locally Advanced Rectal Carcinoma | Phase 2 | Not yet recruiting | Zhejiang University | 51 | 2026-10-01 | 2026-09-08 |
| Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV - Brain Metastases, Adult, Brain Tumor - Metastatic | Phase 2 | Recruiting | Ayal A. Aizer, MD | 60 | 2025-12-30 | 2026-09-08 |
| Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health Time-restricted eating (TRE) + Standard of Care, Standard of Care - Metabolic Syndrome, Pre-diabetes | Phase 2 | Recruiting | University of California, San Diego | 140 | 2025-10-23 | 2026-02-02 |
| Time Restricted Eating in Haematological Malignancies Time-Restricted Eating - Cancer, Chronic Lymphocytic Leukemia | Phase 2 | Not yet recruiting | British Columbia Cancer Agency | 75 | 2025-06-01 | 2025-06-13 |
| Pivotal BE Study of TAH3311 ODF vs ELIQUIS® Tablet Under Fasted Condition in Healthy Volunteers 5 mg Apixaban Oral Dissolving Film (fasting), 5 mg Apixaban Oral Dissolving Film (fed), 5 mg Apixaban Oral Tablet (US RS/RLD) - Random Allocation, Intermittent Fasting | Phase 2 | Completed | TAHO Pharmaceuticals Ltd. | 60 | 2024-11-16 | 2025-04-11 |
| Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue Time-restricted eating, Nutrition counseling - Neoplasms, Blood Cancer | Phase 2 | Recruiting | University of Maryland, Baltimore | 96 | 2024-11-04 | 2026-06-05 |
| Intermittent Fasting Using a Fasting-Mimicking Diet to Improve Prostate Cancer Control and Metabolic Outcomes Fasting Mimicking Diet (FMD), Standard Anti-Cancer Diet - Prostate Adenocarcinoma | Phase 2 | Recruiting | Stephen Freedland | 138 | 2023-09-13 | 2026-08-10 |
| Targeting Triple Negative BREAst Cancer Metabolism With a Combination of Chemoimmunotherapy and a FASTing-like Approach in the Preoperative Setting: the BREAKFAST 2 Trial Control diet (ARM A) or Fasting-Like Approach (FLA, ARM B) - Breast Cancer, Triple Negative Breast Cancer | Phase 2 | Unknown | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 145 | 2023-05-15 | 2023-05-18 |
| Fighting Immunosenescence and Promoting Immunity by a Fasting-mimicking Diet Elderly. Prolon - FMD - Frailty, Inflammation | Phase 1 / Phase 2 | Unknown | University of Genova | 40 | 2020-09-15 | 2021-10-25 |
| Proton Pump Inhibitors Effects on Dyspepsia During Ramadan Fasting Esomeprazole, Placebo - Dyspepsia | Phase 1 / Phase 2 | Completed | University of Monastir | 500 | 2020-01-20 | 2025-02-25 |
| The Effect of Time-restricted Feeding on Physiological Function in Middle-aged and Older Adults Time Restricted Feeding - Aging | Phase 1 / Phase 2 | Unknown | University of Colorado, Boulder | 12 | 2016-04-01 | 2019-06-14 |
| HRZE Fasted/Fed in Newly Diagnosed TB intravenous administration of 1st line TB drugs, day 1 - Tuberculosis | Phase 2 | Completed | University Medical Center Groningen | 20 | 2013-07-01 | 2015-04-08 |
| Residual Gastric Volume After the Ingestion of a Beverage Containing Carbohydrates Plus Whey Protein Carbohydrate plus whey protein enriched drink - Peptic Ulcer, Gastritis | Phase 2 / Phase 3 | Completed | Federal University of Mato Grosso | 30 | 2013-02-01 | 2013-04-10 |
| Early Recovery After Gastric Cancer Surgery Early recovery - Fasting, Malignant Neoplasm of Stomach | Phase 2 | Unknown | Ajou University School of Medicine | 109 | 2012-07-01 | 2012-07-20 |
| Bioavailability Study of Propranolol Under Fasting Conditions Propranolol, Inderal-LA - To Determine Bioequivalence Under Fasting Conditions | Phase 2 | Completed | Par Pharmaceutical, Inc. | 48 | 2005-05-01 | 2008-04-04 |
| Rapid Antidepressant Effects of Yohimbine in Major Depression Yohimbine hydrochloride, Placebo - Depression, Involutional, Major Depresssion | Phase 2 | Completed | National Institute of Mental Health (NIMH) | 11 | 2004-03-01 | 2019-08-29 |
| Role of Leptin in the Neuroendocrine and Immune Response to Fasting r-metHuLeptin, placebo - Fasting | Phase 1 / Phase 2 | Completed | Beth Israel Deaconess Medical Center | 13 | 2002-10-01 | 2017-06-07 |
Intermittent Fasting (7) · Frailty (2) · Inflammation (2) · Neoplasms (2) · Brain Neoplasms (1) · Breast Neoplasms (1) · Depression (1) · Depressive Disorder, Major (1) · Dyspepsia (1) · Fatigue (1) · Feeding Behavior (1) · Gastritis (1) · Glucose Intolerance (1) · Hematologic Neoplasms (1)
Behavior (18) · Feeding Behavior (17) · Pathological Conditions, Signs and Symptoms (8) · Neoplasms by Site (5) · Neoplasms (4) · Pathologic Processes (4) · Digestive System Diseases (3) · Gastrointestinal Diseases (3) · Signs and Symptoms (3) · Digestive System Neoplasms (2) · Disease Attributes (2) · Gastrointestinal Neoplasms (2) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2)
Carbohydrates (1) · Drug Therapy (1) · Esomeprazole (1) · Propranolol (1) · Standard of Care (1) · Trehalase (1) · Yohimbine (1) · apixaban (1) · metreleptin (1) · recombinant methionyl human leptin (1)
University of Maryland, Baltimore (2) · Ajou University School of Medicine (1) · Ayal A. Aizer, MD (1) · Beth Israel Deaconess Medical Center (1) · British Columbia Cancer Agency (1) · Federal University of Mato Grosso (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · National Institute of Mental Health (NIMH) (1) · Par Pharmaceutical, Inc. (1) · Stephen Freedland (1) · TAHO Pharmaceuticals Ltd. (1) · University Medical Center Groningen (1) · University of California, San Diego (1) · University of Colorado, Boulder (1) · University of Genova (1)
United States (9) · Canada (2) · Italy (2) · Brazil (1) · Indonesia (1) · South Korea (1) · Tunisia (1)
Alberto Zambelli, MD (1) · Andrea Botticelli, MD (1) · Ayal A Aizer, MD, MHS (1) · Carla Strina, MD (1) · Carlos A Zarate, M.D. (1) · Christopher R Martens, Ph.D. (1) · Christos S Mantzoros, MD, DSc (1) · Denis Audet (1) · Eleah Stringer, MSc, RD, CSO (1) · Hoon Hur, Prof. (1) · Maria Vittoria Dieci, MD (1) · Matteo Lambertini, MD (1) · Monica Iorfida, MD (1) · Pam Taub, MD (1)
PMID 19299237, PMID 21704134, PMID 21917874, PMID 23193213, PMID 24529560, PMID 25092775, PMID 25540981, PMID 26661397, PMID 27872127, PMID 30997650, PMID 31930513, PMID 32101663, PMID 32393788, PMID 32669709, PMID 32848145, PMID 32966830, PMID 33051459, PMID 33181091, PMID 33278935, PMID 33512717, PMID 34731655, PMID 34789537, PMID 34861375, PMID 35810555, PMID 35820631, PMID 39097160, PMID 41120363, PMID 41174725
M01RR001032 (1), R01CA280081 (1), R01DK058785 (1)