21 completed, 4 withdrawn, 2 not yet recruiting, 1 terminated. 9 Phase 2, 7 Not applicable, 4 Phase 1, 3 Early Phase 1, 3 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder Yohimbine + Hydrocortisone, Active rTMS, Placebo - Opioid Use Disorder | Phase 2 | Not yet recruiting | Wayne State University | 20 | 2026-10-01 | 2025-12-30 |
| Evaluation of Solanidine as an Exogenous Biomarker to Phenotype CYP2D6 Activity in Humans Yohimbine, Consumption of a defined potato-rich meal - Pharmacokinetic Study in Healthy Volunteers | Not applicable | Not yet recruiting | University Medicine Greifswald | 30 | 2026-09-21 | 2026-09-14 |
| Kinetics of Yohimbine in Humans to Explore Sex and CYP2D6 Genotype Interactions Yohimbine, ¹³C₃-caffeine - Pharmacokinetic Study in Healthy Volunteers | Not applicable | Completed | University Medicine Greifswald | 36 | 2025-04-28 | 2026-01-21 |
| Cannabinoids and Biological Reactivity to Stress Hydrocortisone Oral, Yohimbine Hydrochloride, Cornstarch Placebo 20mg - Cannabis Use Disorder | Early Phase 1 | Completed | Florida State University | 38 | 2024-09-30 | 2026-10-22 |
| Role Of Sensitivity to neuroEndocrine Systems in Social Decisions Hydrocortisone, Yohimbine, Placebo - Borderline Personality Disorder | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2024-07-01 | 2024-06-05 | |
| PROWESS (PROstate Cancer Wearables Exercise and Structured Supports): A Pilot Supportive Care Intervention PROWESS - Prostate Cancer, Prostatic Neoplasms | Not applicable | Completed | Massachusetts General Hospital | 14 | 2023-08-28 | 2025-10-02 |
| Using rTMS to Explore Neural Mechanisms of Stress-Induced Opioid Use Placebo oral tablet, Yohimbine + Hydrocortisone, sham rTMS - Stress, Opioid-use Disorder | Phase 2 | Withdrawn | Wayne State University | 2023-04-10 | 2023-04-13 | |
| rTMS of Limbic Circuitry in Stress Modulation in Healthy Volunteers yohimbine + hydrocortisone, medial prefrontal cortex rTMS, Placebo oral tablet - Stress, Healthy | Phase 2 | Withdrawn | Wayne State University | 2023-04-10 | 2023-04-13 | |
| The Role of the Noradrenergic System in the Nonmotor Symptoms of Parkinson's Disease Yohimbine HCl - Parkinson Disease | Early Phase 1 | Withdrawn | Nathaniel M. Robbins | 2021-05-11 | 2023-08-23 | |
| The Role of Stress Neuromodulators in Decision Making Under Risk and Selective Attention to Threat "Yohimbine", "Hydrocortisone", "Yohimbine + Hydrocortisone" - Yohimbine, Hydrocortisone | Not applicable | Completed | Charite University, Berlin, Germany | 167 | 2019-11-01 | 2022-03-15 |
| Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension Yohimbine, Melatonin - Hypotension, Orthostatic, Hypertension | Early Phase 1 | Terminated | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 10 | 2018-03-01 | 2019-06-12 |
| Effects of Stress and Drug-cue Exposure (SCM) Yohimbine - Marijuana Abuse | Phase 1 | Completed | Wayne State University | 12 | 2017-11-01 | 2024-04-23 |
| Investigation of Nicotine Seeking Behavior in Current Smokers Yohimbine Hydrochloride, Hydrocortisone, Lactose Monohydrate Powder - Cigarette Smoking | Phase 1 | Completed | Wayne State University | 21 | 2016-01-07 | 2018-09-13 |
| Noradrenergic Activity, Cognition and Major Depressive Disorder yohimbine, placebo - Major Depressive Disorder, Early Life Trauma | Not applicable | Completed | Charite University, Berlin, Germany | 131 | 2014-06-01 | 2019-05-23 |
| Influence of the Noradrenergic System on the Formation of Intrusive Memories Stress Film, Yohimbine, Clonidine - Intrusive Memories | Not applicable | Completed | Charite University, Berlin, Germany | 118 | 2013-11-01 | 2015-09-04 |
| The Role of Sympatho-vagal Balance on Different Limbs of Pain Perception in Healthy Subjects Yohimbine - Pain | Not applicable | Unknown | Tel-Aviv Sourasky Medical Center | 20 | 2012-08-01 | 2012-06-18 |
| Randomized Study of Yohimbine Treatment for Type 2 Diabetes Patients Carrying a Specific Genetic Risk Variant Yohimbine - Type 2 Diabetes | Phase 2 | Completed | Anders Rosengren, MD PhD | 50 | 2012-05-01 | 2015-01-09 |
| Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) With/Without Yohimbine Yohimbine, Placebo - Post-Traumatic Stress Disorder | Phase 2 | Completed | VA Office of Research and Development | 26 | 2010-12-01 | 2018-02-07 |
| Bioequivalence Study Comparing Two Test Products With One Reference Product, All Containing 5 mg Yohimbine Yohimbine - Erectile Dysfunction | Phase 4 | Completed | Walter Ritter GmbH & Co | 42 | 2009-10-01 | 2015-06-26 |
| Yohimbine to Enhance Cognitive Behavioral Therapy (CBT) for Social Anxiety Group Cognitive Behavioral Therapy, Yohimbine Hydrochloride, Sugar Pill - Social Anxiety Disorder | Phase 3 | Completed | Southern Methodist University | 40 | 2009-03-01 | 2013-11-11 |
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Hypotension, Orthostatic (3) · Depressive Disorder, Major (2) · Erectile Dysfunction (2) · Opioid-Related Disorders (2) · Alcoholism (1) · Autonomic Nervous System Diseases (1) · Borderline Personality Disorder (1) · Cigarette Smoking (1) · Cocaine-Related Disorders (1) · Depression (1) · Diabetes Mellitus, Type 2 (1) · Fasting (1) · Hypertension (1) · Marijuana Abuse (1) · Mood Disorders (1)
Wayne State University (5) · National Institute of Mental Health (NIMH) (4) · Charite University, Berlin, Germany (3) · University Medicine Greifswald (2) · Anders Rosengren, MD PhD (1) · Florida State University (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Medical University of South Carolina (1) · Medical University of Vienna (1) · Nathaniel M. Robbins (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · Southern Methodist University (1) · Tel-Aviv Sourasky Medical Center (1)
United States (17) · Germany (6) · Austria (1) · Canada (1) · Israel (1) · Sweden (1)
Adil E Bharucha, MBBS, M.D. (1) · Anders Rosengren, MD PhD (1) · Carlos A Zarate, M.D. (1) · Daniel Lage, MD (1) · Eric A Woodcock, PhD (1) · Frank Donath, MD (1) · Italo Biaggioni, MD (1) · Jasper Smits, Ph.D. (1) · Kathleen T Brady, M.D., Ph.D. (1) · Leslie Lundahl, PhD (1) · Mark Greenwald, PhD (1) · Mark K Greenwald, PhD (1) · Michael N Hallquist, PhD (1)
PMID 10662747, PMID 11904109, PMID 11927799, PMID 12119802, PMID 12832331, PMID 15066944, PMID 15710782, PMID 15738343, PMID 17515447, PMID 17515448, PMID 20837887, PMID 21704134, PMID 22311903, PMID 24237691, PMID 25809565, PMID 26654474, PMID 27271310, PMID 38581746, PMID 38902928, PMID 39727053, PMID 9727818
F31DA040369 (1), P50DA016511 (1), R21DA058780 (1)