21 completed, 3 recruiting, 3 terminated, 2 unknown. 30 Phase 2, 4 Phase 1, 3 Phase 3.
Follow Exocrine Pancreatic Insufficiency: new trials by email Literature Review of Exocrine Pancreatic Insufficiency trials Research Report on Exocrine Pancreatic Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency. NHS7108, Zenpep® - Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF) | Phase 2 | Recruiting | Aimmune Nestlé Health Science US R&D, LLC | 66 | 2026-10-01 | 2026-10-01 |
| Phase 2 Study to Assess the Safety and Efficacy of ANG003 ANG003 Dose A, ANG003 Dose B, Creon - Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF) | Phase 2 | Recruiting | Anagram Therapeutics, Inc. | 113 | 2026-04-24 | 2026-10-30 |
| Study to Assess an Enteric Microgranule Formulation of Adrulipase in Patients With Cystic Fibrosis adrulipase - Exocrine Pancreatic Insufficiency, Cystic Fibrosis | Phase 2 | Completed | Entero Therapeutics | 13 | 2023-02-01 | 2024-09-19 |
| Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904) Treosulfan, Fludarabine Phosphate, Tacrolimus - Bone Marrow Failure Syndrome, Congenital Amegakaryocytic Thrombocytopenia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2022-04-19 | 2026-03-09 |
| GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance Dulaglutide 0.75Mg/0.5Ml Inj Pen - Cystic Fibrosis, Pancreatic Insufficiency | Phase 2 | Recruiting | University of Pennsylvania | 30 | 2021-07-16 | 2026-05-18 |
| OPTION 2: A Trial to Assess the Safety and Efficacy of MS1819 in Enteric Capsules in Patients With Cystic Fibrosis MS1819, Porcine PERT - Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF) | Phase 2 | Completed | Entero Therapeutics | 27 | 2020-07-20 | 2022-09-13 |
| Phase 2 Combination Study With Escalating Doses of MS1819-SD on Top of a Stable Dose of PPEs MS1819-SD - Cystic Fibrosis, Cystic Fibrosis Gastrointestinal Disease | Phase 2 | Completed | AzurRx SAS | 20 | 2019-06-27 | 2021-08-19 |
| OPTION: A Trial to Assess the Safety & Efficacy of MS1819 in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis MS1819, Porcine PERT - Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF) | Phase 2 | Completed | Entero Therapeutics | 41 | 2019-01-10 | 2022-06-06 |
| Proton Pump Inhibitors (PPI) and Fat Absorption in Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI) Omeprazole 20mg Capsule, Placebo oral capsule - Pancreatic Insufficiency, Cystic Fibrosis | Phase 2 | Completed | Children's Hospital of Philadelphia | 19 | 2018-08-07 | 2024-04-30 |
| Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer Cyclophosphamide, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission | Phase 2 | Terminated | Roswell Park Cancer Institute | 31 | 2017-12-07 | 2025-07-04 |
| A Phase IIa Study With Escalating Dose of MS1819-SD MS1819-SD - Chronic Pancreatitis, Distal Pancreatectomy | Phase 2 | Completed | AzurRx SAS | 11 | 2017-01-27 | 2018-09-28 |
| PERT for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer Pancrelipase, Placebo Oral Capsule - Pancreatic Insufficiency, Pancreatic Cancer | Phase 1 / Phase 2 | Terminated | Massimo Raimondo, M.D. | 16 | 2016-12-01 | 2021-03-15 |
| Fat Malabsorption in Chronic Pancreatitis Creon36™ - Chronic Pancreatitis | Phase 2 | Completed | Children's Hospital of Philadelphia | 48 | 2016-10-13 | 2019-05-03 |
| A Study to Investigate How Common Pancreatic Exocrine Insufficiency (PEI) is in Patients With Type 2 Diabetes and Also to Investigate the Uptake of a Single Dose of EPANOVA® or OMACOR® in Patients With Different Degrees of PEI Epanova® (omega-3 carboxylic acids), Omacor® (omega-3-acid ethyl esters) - Diabetes Mellitus, Type 2, Exocrine Pancreatic Insufficiency | Phase 2 | Completed | AstraZeneca | 490 | 2015-03-01 | 2017-01-20 |
| Efficacy and Safety Study of Creon IR in Subjects With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Creon IR, Creon® (DR/GR) - Exocrine Pancreatic Insufficiency in Subjects With Cystic Fibrosis | Phase 2 | Completed | Abbott | 70 | 2015-03-01 | 2016-04-04 |
| CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant CliniMACS CD34+ Reagent System, Thiotepa, Cyclophosphamide - Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML) | Phase 1 / Phase 2 | Unknown | Diane George | 14 | 2013-06-03 | 2024-06-04 |
| Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis Burlulipase, Placebo (Caramel in sterile water) - Pancreatic Insufficiency, Cystic Fibrosis | Phase 1 / Phase 2 | Completed | Nordmark Arzneimittel GmbH & Co. KG | 35 | 2013-05-01 | 2016-06-07 |
| CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation CD34 Stem Cell Selection Therapy - Bone Marrow Failure Syndrome, Severe Aplastic Anemia | Phase 1 / Phase 2 | Active not recruiting | Diane George | 37 | 2013-03-01 | 2025-08-14 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| Clinical Non-Inferiority of Pancreatic Enzymes (Norzyme ® - Bergamo) Compared To Creon ® (Solvay Pharmaceutical) in Patients With Exocrine Pancreatic Insufficiency Norzyme - Bergamo, Creon - Pancreatic Insufficiency | Phase 2 / Phase 3 | Unknown | Azidus Brasil | 25 | 2010-03-01 | 2010-10-28 |
Showing 20 of 30. Sign in to see all of them.
Cystic Fibrosis (13) · Shwachman-Diamond Syndrome (9) · Anemia, Diamond-Blackfan (8) · Anemia, Aplastic (5) · Anemia, Sickle Cell (5) · Bone Marrow Failure Disorders (5) · Neutropenia, Severe Congenital, Autosomal Recessive 3 (5) · Congenital amegakaryocytic thrombocytopenia (3) · Hemoglobinopathies (3) · Hemoglobinuria, Paroxysmal (3) · Leukemia, Myeloid, Acute (3) · Lymphohistiocytosis, Hemophagocytic (3) · Pancreatitis, Chronic (3) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (3)
Digestive System Diseases (29) · Pancreatic Diseases (29) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (22) · Genetic Diseases, Inborn (22) · Infant, Newborn, Diseases (14) · Lung Diseases (14) · Respiratory Tract Diseases (14) · Nutritional and Metabolic Diseases (12) · Metabolic Diseases (11) · Anemia (9) · Anemia, Hypoplastic, Congenital (9) · Bone Marrow Diseases (9) · Congenital Bone Marrow Failure Syndromes (9) · Hemic and Lymphatic Diseases (9)
Pancrelipase (7) · fludarabine phosphate (7) · Antilymphocyte Serum (4) · Peripheral Blood Stem Cell Transplantation (4) · Tacrolimus (4) · Whole-Body Irradiation (4) · Busulfan (3) · Cyclophosphamide (3) · Methotrexate (3) · Alemtuzumab (2) · Bone Marrow Transplantation (2) · Melphalan (2) · Mycophenolic Acid (2) · fludarabine (2) · merphos (2)
Entero Therapeutics (3) · AzurRx SAS (2) · Children's Hospital of Philadelphia (2) · Diane George (2) · Fred Hutchinson Cancer Center (2) · Masonic Cancer Center, University of Minnesota (2) · Roswell Park Cancer Institute (2) · Abbott (1) · Aimmune Nestlé Health Science US R&D, LLC (1) · Anagram Therapeutics, Inc. (1) · Anthera Pharmaceuticals (1) · AstraZeneca (1) · Avanti Polar Lipids, Inc. (1) · Axcan Pharma (1) · Azidus Brasil (1)
United States (21) · Poland (7) · Hungary (5) · Czechia (2) · Denmark (2) · Latvia (2) · Spain (2) · Sweden (2) · Australia (1) · Brazil (1) · Bulgaria (1) · France (1) · Italy (1) · Netherlands (1) · New Zealand (1)
Diane George, MD (2) · Andrea Kelly, MD, MSCE (1) · Angela Smith, MD (1) · Babette Zemel, PhD (1) · David A. Williams (1) · George Chen (1) · James E. Heubi, MD (1) · Janneke Langendonk, MD, PhD (1) · Jean-Pierre Isal, MD, PhD (1) · Kristin Forssmann, MD (1) · Lauri Burroughs, MD (1) · Lauri M. Burroughs (1) · Margaret MacMillan, MD (1) · Massimo Raimondo, MD (1)
PMID 24345827, PMID 24518280, PMID 26465792, PMID 27050056, PMID 27297209, PMID 29802077, PMID 32384122, PMID 32761612, PMID 37671264
2014 (2), 2025 (1), P30CA015704 (1), R44DK060302 (1), U10HL069294 (1)