5 completed, 3 terminated, 1 active not recruiting, 1 recruiting. 11 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 5, Terminated 3, Active not recruiting 1, Recruiting 1, Unknown 1 |
| Phase 2 | 4 | Active not recruiting 1, Completed 1, Terminated 1, Unknown 1 |
Follow Exocrine Pancreatic Insufficiency: new trials by email Literature Review of Exocrine Pancreatic Insufficiency trials Research Report on Exocrine Pancreatic Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis Dorzagliatin, Placebo - Pancreatic Insufficiency, Cystic Fibrosis-related Diabetes | Phase 1 | Recruiting | Michael R. Rickels, MD, MS | 15 | 2025-10-21 | 2026-08-31 |
| Phase 1 Study to Assess Safety and Efficacy of ANG003 ANG003 - Exocrine Pancreatic Insufficiency | Phase 1 | Completed | Anagram Therapeutics, Inc. | 57 | 2023-08-25 | 2026-04-27 |
| Oral CDX-7108 in Healthy Adults and EPI Subjects Part A, Part B, Part C - Exocrine Pancreatic Insufficiency | Phase 1 | Completed | Société des Produits Nestlé (SPN) | 54 | 2021-10-11 | 2024-09-20 |
| PERT for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer Pancrelipase, Placebo Oral Capsule - Pancreatic Insufficiency, Pancreatic Cancer | Phase 1 / Phase 2 | Terminated | Massimo Raimondo, M.D. | 16 | 2016-12-01 | 2021-03-15 |
| Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases BPX-501 and Rimiducid - Primary Immune Deficiency Disorders, Hemophagocytic Lymphohistiocytosis | Phase 1 | Terminated | Bellicum Pharmaceuticals | 1 | 2015-02-01 | 2024-03-25 |
| Bone Marrow Transplant With Abatacept for Non-Malignant Diseases Abatacept - Hurler Syndrome, Fanconi Anemia | Phase 1 | Completed | Emory University | 10 | 2014-01-01 | 2019-12-26 |
| CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant CliniMACS CD34+ Reagent System, Thiotepa, Cyclophosphamide - Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML) | Phase 1 / Phase 2 | Unknown | Diane George | 14 | 2013-06-03 | 2024-06-04 |
| Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis Burlulipase, Placebo (Caramel in sterile water) - Pancreatic Insufficiency, Cystic Fibrosis | Phase 1 / Phase 2 | Completed | Nordmark Arzneimittel GmbH & Co. KG | 35 | 2013-05-01 | 2016-06-07 |
| CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation CD34 Stem Cell Selection Therapy - Bone Marrow Failure Syndrome, Severe Aplastic Anemia | Phase 1 / Phase 2 | Active not recruiting | Diane George | 37 | 2013-03-01 | 2025-08-14 |
| A Study of EUR-1066 in Subjects With Chronic Pancreatitis, Exocrine Pancreatic Insufficiency and Chronic Abdominal Pain EUR-1066-A, Zenpep, EUR-1066-B - Chronic Pancreatitis | Phase 1 | Terminated | Forest Laboratories | 15 | 2010-08-02 | 2020-01-18 |
| A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI) Ensure Plus, Pancrelipase in combination with Ensure Plus - Exocrine Pancreatic Insufficiency, Pancreatitis, Chronic | Phase 1 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 13 | 2008-07-01 | 2011-05-19 |
Anemia, Diamond-Blackfan (4) · Anemia, Sickle Cell (4) · Lymphohistiocytosis, Hemophagocytic (4) · Shwachman-Diamond Syndrome (4) · Anemia, Aplastic (3) · Hemoglobinopathies (3) · Neutropenia, Severe Congenital, Autosomal Recessive 3 (3) · Primary Immunodeficiency Diseases (3) · Acquired Immunodeficiency Syndrome (2) · Bone Marrow Failure Disorders (2) · Cystic Fibrosis (2) · Dyskeratosis Congenita (2) · Fanconi Anemia (2) · Granulomatous Disease, Chronic (2)
Pancreatic Diseases (11) · Digestive System Diseases (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Genetic Diseases, Inborn (6) · Chronic Disease (5) · Disease Attributes (5) · Nutritional and Metabolic Diseases (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Anemia (4) · Anemia, Hemolytic (4) · Anemia, Hemolytic, Congenital (4) · Anemia, Hypoplastic, Congenital (4) · Bone Marrow Diseases (4)
Pancrelipase (3) · Abatacept (1) · Alemtuzumab (1) · Busulfan (1) · Cyclophosphamide (1) · Dorzagliatin (1) · Ensure Plus (1) · Medicare Part B (1) · Medicare Part C (1) · Melphalan (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Tacrolimus (1) · Thiotepa (1) · caramel coloring (1)
Diane George (2) · Anagram Therapeutics, Inc. (1) · Bellicum Pharmaceuticals (1) · Emory University (1) · Forest Laboratories (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Massimo Raimondo, M.D. (1) · Michael R. Rickels, MD, MS (1) · Nordmark Arzneimittel GmbH & Co. KG (1) · Société des Produits Nestlé (SPN) (1)
United States (9) · Australia (1) · New Zealand (1)
Diane George, MD (2) · Chris Wynne (1) · James E. Heubi, MD (1) · John T Horan, MD (1) · John Windsor (1) · Kristin Forssmann, MD (1) · Massimo Raimondo, MD (1) · Meghana Sathe, MD (1) · Michael R Rickels, MD, MS (1) · Nam Nguyen (1) · Phillip Toskes, MD (1) · Richard Stubbs (1)