8 recruiting, 4 completed, 3 not yet recruiting, 2 unknown. 7 Not applicable, 2 Phase 1, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 5, Completed 1, Unknown 1 |
| Phase 1 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 4 | 1 | Active not recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PACE: Prostacyclin AntiCoagulation in ECMO Dose-escalation study of epoprostenol as adjunct anticoagulation in ECMO - ECMO | Phase 1 / Phase 2 | Not yet recruiting | Garrett Keim | 44 | 2026-10-01 | 2026-09-24 |
| TwichView-guided Atricurium Dose Adjustment Trial EMG-based quantitative TOF-guided atracurium titration - ARDS, TTM | Not applicable | Recruiting | Fu Jen Catholic University Hospital | 120 | 2026-08-19 | 2026-09-08 |
| PERCEPTION - Super-Early Neuroprognostication in eCPR Patients Automated Pupillometry, continuous near-infrared spectroscopy (cNIRS) - Resuscitation, Extra Corporeal Life Support | Recruiting | Medical University of Vienna | 45 | 2026-05-12 | 2026-05-14 | |
| Early Intra-aortic Balloon Pump Use After Venoarterial Extracorporeal Membrane Oxygenation Early IABP use, Conventional approach - ECMO | Not applicable | Recruiting | Beijing Anzhen Hospital | 358 | 2026-03-22 | 2026-03-24 |
| Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Recruiting | Charite University, Berlin, Germany | 80 | 2025-12-05 | 2026-10-15 |
| Effect of Initiation of Veno-venous ECMO on Urine Output and Acute Kidney Injury ARDS (Acute Respiratory Distress Syndrome), Acute Kidney Injury | Completed | University Hospital, Ghent | 76 | 2025-12-01 | 2026-01-30 | |
| EVOLUTION OF D-DIMER AS A MARKER OF BLEEDING RISK ON ECMO Blood sampling collection - ECMO, Mplementation of a Veno-venous VV or Veno-arterial VA | Not yet recruiting | University Hospital, Strasbourg, France | 100 | 2025-11-27 | 2025-12-01 | |
| A Novel Strategy of ECMO Management Using Nafamostat for Regional Combined With Low Intensity Systematic Anticoagulation Nafamostat, Heparin - ECMO | Not applicable | Recruiting | Beijing Chao Yang Hospital | 140 | 2025-05-10 | 2026-09-09 |
| Standby Cannulated ECMO for High-Risk Percutaneous Coronary Intervention Standby cannulated ECMO, Prophylactic ECMO - ECMO, High-risk PCI | Not applicable | Recruiting | Beijing Anzhen Hospital | 176 | 2025-03-21 | 2026-05-13 |
| Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO Red Blood Cell transfusion - Transfusion, Red Blood Cell | Not applicable | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 526 | 2024-11-26 | 2026-08-14 |
| The ECMOCYP (cytochromes P450 Activity) Study phenotype - ECMO, Cardiogenic Shock | Recruiting | University Hospital, Geneva | 46 | 2024-10-01 | 2024-10-28 | |
| Virtual Reality Training for ECMO Circuit Checks Virtual Reality ECMO Simulation Training, Instructional Video of Certified Perfusionists on Performing a Circuit Check - ECMO, Training Effectiveness | Not applicable | Completed | Leiden University Medical Center | 42 | 2024-01-29 | 2025-08-24 |
| Precise Treatment of Ceftazidime-Avibactam in Patients With CRO Infections Under the Guidance of TDM and PPK Model ceftazidime avibactam - ECMO, Carbapenem-Resistant Enterobacteriaceae Infection | Not yet recruiting | Sichuan Provincial People's Hospital | 50 | 2024-01-01 | 2024-01-18 | |
| Can Blood Panels Provide Early Warning of Bleeding in Patients on ECMO? Blood test of factor levels - ECMO, Bleeding | Withdrawn | Montefiore Medical Center | 2021-12-01 | 2022-04-28 | ||
| Effects of Ulinastatin on Inflammatory Response During ECMO Support ulinastatin - ECMO, Inflammatory Response | Unknown | Nanfang Hospital, Southern Medical University | 144 | 2021-07-26 | 2021-08-04 | |
| Safety and Effectiveness of Low-flow ECMO Driving by CVVH Machine in Severe NCP Low flow ECMO driving by CVVH machine - COVID-19, ECMO | Not applicable | Unknown | Peking Union Medical College Hospital | 10 | 2020-02-20 | 2020-06-16 |
| Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) Heparin Study subcutaneous heparin anticoagulation - ECMO, Heparin | Phase 4 | Active not recruiting | Baylor Research Institute | 100 | 2018-10-10 | 2026-01-30 |
| To Construct a Prognosis Prediction Model for ECMO Patients Based on Machine Learning Algorithms ECMO | Completed | Zhujiang Hospital | 290 | 2018-01-01 | 2024-10-23 | |
| Cardinality Matching Study of Early v.s. Delayed VV ECMO in Severe Respiratory Failure Acute Respiratory Failure, ECMO | Completed | University of Cambridge | 667 | 2011-12-01 | 2021-04-27 |
Acute Kidney Injury (1) · Acute Lung Injury (1) · Anemia (1) · COVID-19 (1) · Heart Defects, Congenital (1) · Hemorrhage (1) · Respiratory Distress Syndrome (1) · Respiratory Insufficiency (1) · Shock, Cardiogenic (1) · Tetralogy of Fallot (1)
Respiratory Tract Diseases (4) · Cardiovascular Diseases (3) · Heart Diseases (3) · Lung Diseases (3) · Cardiovascular Abnormalities (2) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Respiration Disorders (2) · Coronaviridae Infections (1) · Coronavirus Infections (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Heart Defects, Congenital (1)
Erythrocyte Transfusion (1) · Extracorporeal Membrane Oxygenation (1) · Heparin (1) · Phenotype (1) · Standard of Care (1) · avibactam, ceftazidime drug combination (1) · nafamostat (1) · urinastatin (1)
Beijing Anzhen Hospital (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Baylor Research Institute (1) · Beijing Chao Yang Hospital (1) · Charite University, Berlin, Germany (1) · Fu Jen Catholic University Hospital (1) · Garrett Keim (1) · Leiden University Medical Center (1) · Medical University of Vienna (1) · Montefiore Medical Center (1) · Nanfang Hospital, Southern Medical University (1) · Peking Union Medical College Hospital (1) · Sichuan Provincial People's Hospital (1) · University Hospital, Geneva (1) · University Hospital, Ghent (1)
China (6) · Austria (2) · Belgium (2) · Netherlands (2) · United States (2) · France (1) · Germany (1) · Sweden (1) · Switzerland (1) · Taiwan (1)
Alexander P.J. Vlaar, PhD (1) · Bing Sun, MD (1) · Gary Schwartz, MD (1) · Kiri Mackersey, MBChB (1) · Xiaotong Hou, MD (1) · Xiaotong Hou, MD, PhD (1) · Yun Long (1) · Zhongqing Chen, doctor (1)
PMID 32454016, PMID 34307397, PMID 37548758
2023 (2), 2019 (1)