7 completed, 5 recruiting, 2 not yet recruiting, 1 active not recruiting. 9 Not applicable, 2 Phase 2, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 6, Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 2 | Active not recruiting 1, Recruiting 1 |
| Phase 4 | 2 | Not yet recruiting 1, Recruiting 1 |
Follow Dry Eye Syndrome (DES): new trials by email Literature Review of Dry Eye Syndrome (DES) trials Research Report on Dry Eye Syndrome (DES)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Proteomic Factors in Patients With Severe Dry Eye Syndrome Treated With Autologous Serum Eye Drops. Autologous serum eye drops, Collecting data from the medical record - Dry Eye Syndrome (DES), Dry Eye | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 68 | 2026-07-07 | 2026-07-09 |
| A Multicenter, Open-Label Study to Evaluate Perioperative Treatment of Dry Eye With Miebo® in Subjects Undergoing LASIK Miebo four times per day - Dry Eye Syndrome (DES), Dry Eye Disease (DED) | Phase 4 | Recruiting | Vance Thompson Vision | 100 | 2026-05-05 | 2026-06-24 |
| Evaluation of a Novel Ocular Lubricating Eye Drop Part 2 ABR2 At least twice a day for 28 days, Part 1: ABR2 single dose in one eye - Dry Eye Syndrome (DES) | Not applicable | Recruiting | Pleryon Therapeutics (Hangzhou) Limited | 40 | 2026-05-01 | 2026-05-19 |
| Impact of Filtration on Autologous Serum Eye Drops Serum dosage of TGF-β, IGF-1, EGF, Fibronectin and Vitamin A - Dry Eye Syndrome (DES) | Not applicable | Completed | University Hospital, Limoges | 10 | 2026-04-13 | 2026-05-29 |
| Evaluate the Safety and Efficacy of TJO-087 TJO-087, Vehicle (Placebo solution) - Dry Eye Syndrome (DES) | Phase 2 | Active not recruiting | Taejoon Pharmaceutical Co., Ltd. | 90 | 2026-04-06 | 2026-09-09 |
| Safety and Efficacy of Kelulut Honey Eyedrops in Dry Eye Disease Kelulut Honey Eyedrop 12.5%, Kelulut Honey Eyedrop 25%, Kelulut Honey Eyedrop 50% - Dry Eye Disease (DED), Dry Eye Syndrome (DES) | Not applicable | Not yet recruiting | Universiti Sains Malaysia | 45 | 2026-04-01 | 2025-12-12 |
| This is a Single Center, Open-label Prospective Study to Evaluate the Effect of Xiidra® (Lifitegrast Ophthalmic Solution 5.0%) on Tear Film Biomarkers in Dry Eye (Xiidra®) Lifitegrast Ophthalmic Solution 5.0% - Ocular Surface Disease, Dry Eye Syndrome (DES) | Phase 4 | Not yet recruiting | Pittsburgh Research Institute | 36 | 2026-03-01 | 2026-03-24 |
| Laser Acupuncture on Dry Eye and Sjögren's Syndrome-related Dry Eye Symptoms (LADESJS) Laser acupuncture (LA), Numerical Rating Scale (NRS), Schirmer's test - Dry Eye Syndrome (DES), Laser Acupuncture | Phase 2 | Recruiting | Taipei Veterans General Hospital, Taiwan | 140 | 2025-02-03 | 2025-04-09 |
| Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome acupuncture GB20 or GB20 plus BL2, Chinese herbal tea TBDESJS - Dry Eye Syndrome (DES), Sjogren's Syndrome | Recruiting | Taipei Veterans General Hospital, Taiwan | 220 | 2025-01-16 | 2025-01-17 | |
| Twice-Daily Systane Complete Versus Four-Times-Daily Thealoz Duo for Dry Eye Disease Systane Complete, Thealoz Duo - Dry Eye Syndrome (DES), Ocular Surface Disease | Not applicable | Completed | Instituto Internacional de Medicina y Terapia (IIMET) | 120 | 2025-01-06 | 2026-07-24 |
| Evaluation of Performance and Safety of Eye Drops With Hyaluronic Acid 0.30% and 0.15% BLUgel A, BLUyal A - Dry Eye Syndrome (DES) | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 101 | 2023-06-21 | 2026-09-18 |
| Dietary Supplementation on Tear Secretion and Inflammation in DES Multicomponent dietary supplement group - Dry Eye Syndrome (DES) | Not applicable | Completed | Shih Chien Huang | 52 | 2021-09-27 | 2025-05-14 |
| Post-marketing Study Focused on Evaluating I+Med's DayDrop for Improving Signs and Symptoms of Mild/Moderate Dry Eye DayDrop® - Dry Eye, Dry Eye Syndrome (DES) | Not applicable | Completed | i+Med S.Coop. | 20 | 2021-02-17 | 2024-12-12 |
| Ocular Surface Disease Index and Dry Eye Parameters in Hand Osteoarthritis Dry Eye and Ocular Surface Assessments - Dry Eye Syndrome (DES), Hand Osteoarthritis | Completed | Medipol University | 23 | 2020-11-15 | 2026-08-27 | |
| Potential Role of Ocular Surface Microbiome in Dry Eye: Microbial Interactions and Symptom Alleviation topical cyclosporine eyedrops and hyaluronic eyedrops - Dry Eye Syndrome (DES) | Not applicable | Completed | Hallym University Kangnam Sacred Heart Hospital | 50 | 2020-01-20 | 2025-09-03 |
| Three Dimension Tomography of Eye Structures by White Light Imaging Device None invasive imaging of the tear film (AdOM) - Healthy Subjects, Moderate to Severe Keratoconjunctivitis Sicca (KCS) | Unknown | Meir Medical Center | 60 | 2015-04-01 | 2015-04-23 |
Dry Eye Syndromes (16) · Sjogren's Syndrome (2) · Inflammation (1) · Xerophthalmia (1)
Eye Diseases (16) · Lacrimal Apparatus Diseases (16) · Arthritis (2) · Arthritis, Rheumatoid (2) · Autoimmune Diseases (2) · Connective Tissue Diseases (2) · Immune System Diseases (2) · Joint Diseases (2) · Mouth Diseases (2) · Musculoskeletal Diseases (2) · Rheumatic Diseases (2) · Salivary Gland Diseases (2) · Skin and Connective Tissue Diseases (2) · Stomatognathic Diseases (2) · Xerostomia (2)
Epidermal Growth Factor (1) · Fibronectins (1) · Hyaluronic Acid (1) · Insulin-Like Growth Factor I (1) · Vitamin A (1) · lifitegrast (1)
Taipei Veterans General Hospital, Taiwan (2) · Centre Hospitalier Universitaire de Saint Etienne (1) · Fidia Farmaceutici s.p.a. (1) · Hallym University Kangnam Sacred Heart Hospital (1) · Instituto Internacional de Medicina y Terapia (IIMET) (1) · Medipol University (1) · Meir Medical Center (1) · Pittsburgh Research Institute (1) · Pleryon Therapeutics (Hangzhou) Limited (1) · Shih Chien Huang (1) · Taejoon Pharmaceutical Co., Ltd. (1) · Universiti Sains Malaysia (1) · University Hospital, Limoges (1) · Vance Thompson Vision (1) · i+Med S.Coop. (1)
Taiwan (3) · France (2) · South Korea (2) · United States (2) · Canada (1) · Italy (1) · Malaysia (1) · Mexico (1) · Spain (1) · Turkey (Türkiye) (1)
Charis Lau, PharmD, OD (1) · Ching-Mao Chang, M.D., Ph.D. (1) · Dalia Denisse Ng-Aleman, MD (1) · Jill Woods, MSc, MCOptom (1) · Leanne T Labriola, DO, MBA (1) · Maxime Rocher, Dr (1) · Noa Geffen, MD (1) · Rita Mencucci, MD (1) · Shih-Chien Huang, Dr (1)