10 completed, 2 recruiting, 2 unknown, 2 withdrawn. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Completed 10, Recruiting 2, Unknown 2, Withdrawn 2, Active not recruiting 1 |
Follow Drug Misuse: new trials by email Literature Review of Drug Misuse trials Research Report on Drug Misuse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Bundled Intervention to End Opioid Overdoses Bundled intervention (Experimental), control group, Buprenorphine (Experimental) - Opioid Use Disorder, Opioid Overdose | Phase 4 | Recruiting | University of Alabama at Birmingham | 160 | 2026-09-07 | 2026-10-02 |
| A Bundled Intervention a bundled intervention, including peer support specialist, buprenorphine, physician care, and telehealth - Opioid Use Disorder, Opioid Overdose | Phase 4 | Completed | University of Alabama at Birmingham | 30 | 2025-02-13 | 2026-10-28 |
| Blood Naloxone Levels Following Intradermal Injection in Humans intradermal naloxone, microneedle injection - Opioid Overdose | Phase 4 | Withdrawn | Johns Hopkins University | 2024-08-01 | 2024-11-01 | |
| Vending Machine Naloxone Distribution for Your Community (VENDY) VENDY - Harm Reduction, Naloxone | Phase 4 | Active not recruiting | University of Colorado, Denver | 4000 | 2024-06-01 | 2026-06-02 |
| Clinical Outcomes From Nalmefene Nalmefene Hydrochloride Injection, Naloxone Hydrochloride Injection - Opioid Overdose | Phase 4 | Withdrawn | Purdue Pharma LP | 2023-06-01 | 2023-07-12 | |
| Does a Soft Drink Mixture Improve Tolerance of Activated Charcoal in the Adult Poisoned Patient Without Affecting Efficacy Activated Charcoal - Overdose | Phase 4 | Completed | State University of New York - Upstate Medical University | 5 | 2023-01-04 | 2024-05-30 |
| Increasing Naloxone Access for Persons Who Use Opioids Opioid Overdose Education with Naloxone Distribution, Opioid Overdose Education - Naloxone | Phase 4 | Completed | University of Alabama at Birmingham | 111 | 2021-07-11 | 2023-10-30 |
| Young Houston Emergency Opioid Engagement System Buprenorphine, Naloxone Drug Combination, Individual Counseling, Peer Recovery Support Services - Opioid-use Disorder, Opioid Dependence | Phase 4 | Recruiting | The University of Texas Health Science Center, Houston | 250 | 2021-04-19 | 2025-10-01 |
| Rapid Initiation of Drug Treatment Engagement buprenorphine/naloxone - Opioid-use Disorder, Overdose | Phase 4 | Completed | University of Pennsylvania | 104 | 2019-07-15 | 2024-09-03 |
| Glucagon's Cardiovascular Effects With and Without Beta-blocker-induced Cardioinhibition Glucagon, Esmolol, Physiologic saline - glucagon dummy - Drug Overdose, Overdose of Beta-adrenergic Blocking Drug | Phase 4 | Completed | University Hospital Bispebjerg and Frederiksberg | 10 | 2018-06-01 | 2019-10-17 |
| Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol. metoprolol, intravenous lipid emulsion, Sodium chloride 0.9% solution - lipid emulsion dummy - Drug Overdose, Overdose of Beta-adrenergic Blocking Drug | Phase 4 | Completed | Mikkel Bring Christensen | 10 | 2016-09-01 | 2017-04-12 |
| Surveillance and Treatment of Prisoners With Hepatitis C Sofosbuvir/velpatasvir - Hepatitis C | Phase 4 | Completed | Kirby Institute | 3692 | 2014-10-01 | 2019-12-09 |
| Abuse Liability of Controlled-Release Oxycodone Formulations Apo-Oxycodone CR®, OxyNEO®, Placebo - Substance-Related Disorders | Phase 4 | Completed | Centre for Addiction and Mental Health | 11 | 2014-02-01 | 2015-01-09 |
| Nasal Naloxone for Narcotic Overdose Intranasal (IN) naloxone, Intravenous (IV) naloxone, Intramuscular (IM) naloxone - Drug Overdose | Phase 4 | Unknown | Judith Feinberg | 236 | 2013-09-01 | 2013-07-31 |
| Project OOPEN: Opioid Overdose Prevention, Education and Intervention OOPEN+BBCC - Opioid Overdose | Phase 4 | Completed | University of Washington | 256 | 2013-01-01 | 2022-01-11 |
| Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP) Ondansetron, acetylcysteine - Overdose | Phase 4 | Completed | University of Edinburgh | 222 | 2010-09-01 | 2013-07-31 |
| Detoxification and Treatment of Subjects With Medication Overuse Headache Almotriptan, Topiramate - Analgesic Rebound Headache | Phase 4 | Unknown | The New England Center for Headache, P.C. | 60 | 2007-01-01 | 2007-02-08 |
Opiate Overdose (8) · Drug Overdose (6) · Opioid-Related Disorders (4) · Emergencies (2) · Substance-Related Disorders (2) · Communicable Diseases (1) · Harm Reduction (1) · Headache Disorders, Secondary (1) · Hepatitis C (1) · Poisoning (1) · Prescription Drug Misuse (1) · Prescription Drug Overuse (1)
Chemically-Induced Disorders (17) · Mental Disorders (17) · Prescription Drug Misuse (15) · Substance-Related Disorders (15) · Narcotic-Related Disorders (9) · Drug Overdose (8) · Opioid-Related Disorders (5) · Disease Attributes (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Behavior (1) · Blood-Borne Infections (1) · Brain Diseases (1) · Central Nervous System Diseases (1)
Naloxone (3) · Buprenorphine (2) · Buprenorphine, Naloxone Drug Combination (2) · Saline Solution (2) · Acetylcysteine (1) · Charcoal (1) · Community-Institutional Relations (1) · Control Groups (1) · Fat Emulsions, Intravenous (1) · Glucagon (1) · Glucagon-Like Peptide 1 (1) · Injections, Intramuscular (1) · Jupiter (1) · Metoprolol (1) · Ondansetron (1)
University of Alabama at Birmingham (3) · Centre for Addiction and Mental Health (1) · Johns Hopkins University (1) · Judith Feinberg (1) · Kirby Institute (1) · Mikkel Bring Christensen (1) · Purdue Pharma LP (1) · State University of New York - Upstate Medical University (1) · The New England Center for Headache, P.C. (1) · The University of Texas Health Science Center, Houston (1) · University Hospital Bispebjerg and Frederiksberg (1) · University of Colorado, Denver (1) · University of Edinburgh (1) · University of Pennsylvania (1) · University of Washington (1)
United States (10) · Denmark (2) · Australia (1) · Canada (1) · United Kingdom (1)
Li Li, MD;PhD (2) · Alasdair J Gray (1) · Beth Sproule, PharmD (1) · Fred D Sheftell, M.D. (1) · Gregory Dore, MBBS,PhD (1) · Harry K Thanacoody (1) · James R Langabeer, PhD (1) · Jamie G Cooper (1) · Judith Feinberg, MD (1) · Kasper M Petersen, MD (1) · Kathryn Rosenblatt, MD (1) · Michelle Sisson, MA (1) · Mikkel B Christensen, MD, PhD (1) · Nicole Wagner, PhD (1)
PMID 23556549, PMID 24290406, PMID 29436397, PMID 33103603, PMID 33965006, PMID 35362522, PMID 37091508, PMID 37336007, PMID 38344130, PMID 39514898
2009 (1), R01DA030351 (1), R33DA062351 (1), R61DA062351 (1)