8 recruiting, 4 completed, 2 not yet recruiting, 1 active not recruiting. 8 Not applicable, 3 Phase 3, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Recruiting 5, Completed 2, Active not recruiting 1 |
| Phase 3 | 3 | Recruiting 3 |
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow Down Syndrome (DS): new trials by email Literature Review of Down Syndrome (DS) trials Research Report on Down Syndrome (DS)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome MIB-626, Placebo - Down Syndrome (DS) | Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 24 | 2026-08-31 | 2026-08-19 |
| Amyloid Lowering for Alzheimer's in Down's With Donanemab Investigation Donanemab, Placebo - Down Syndrome (DS), Down Syndrome (Trisomy 21) | Phase 4 | Not yet recruiting | Michael Rafii, MD, PhD | 60 | 2026-08-01 | 2026-05-15 |
| Adapting RDAD for DS Remote Exercise Sessions, Caregiver Education Sessions - Down Syndrome (DS), Alzheimer's Disease (AD) | Not applicable | Recruiting | University of Kansas Medical Center | 40 | 2026-03-31 | 2026-08-03 |
| The Impact of Core Stability Versus Respiratory Muscle Strengthening Exercises on Bone Mineral Density in Children With Down Syndrome Core Stability Exercise Group, Respiratory Muscle Strengthening Group, Control /Conventional Physiotherapy Group - Down Syndrome (DS), Low Bone Mineral Density | Not applicable | Active not recruiting | Cairo University | 60 | 2026-02-20 | 2026-05-11 |
| LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome Levetiracetam 500mg, Placebo - Down Syndrome, Down Syndrome (DS) | Phase 3 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 120 | 2025-12-22 | 2026-01-12 |
| Effects of Chronic Creatine and Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Oxidative Stress, Inflammation, Muscle Strength, and Body Composition in Individuals With Down Syndrome Nutrition education, Supplement, Placebo - Down Syndrome (DS), Supplementation | Not applicable | Completed | Universidad de Burgos | 32 | 2025-09-15 | 2026-10-30 |
| The Effect of the HEP Approach in Infants With Down Syndrome HEP Intervention, Traditional Therapy - Down Syndrome (DS) | Not applicable | Recruiting | Izgi Miray Demirbag | 26 | 2025-09-03 | 2025-11-14 |
| Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome Epi-ON corneal cross-linking (CXL) - Down Syndrome (DS), Keratoconus | Phase 3 | Recruiting | Woolfson Eye Institute | 225 | 2025-08-01 | 2026-02-02 |
| The Efficacy of Therapy in Patients With Acute Myeloid Leukemia and Down Syndrome in Russia 4 chemotherapy blocks: Course 1 AIE (cytarabine/idarubicin/etoposide), Course 2 AI (cytarabine/idarubicin), Course 3 HAD (high-dose cytarabine (1g)/daunorubicin), Course 4 HA (high-dose cytarabine). - AML (Acute Myelogenous Leukemia), Down Syndrome (DS) | Phase 3 | Recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 100 | 2025-07-24 | 2025-11-20 |
| Effects of a Structured Physical Activity Program on Balance and Functional Performance in Children With Down Syndrome Yoga Program - Down Syndrome (DS), Balance Assessment | Not applicable | Completed | Ankara University | 15 | 2025-06-01 | 2026-04-16 |
| Awareness of Families With Down Syndrome Children About the Role of Physical Therapy in Egypt Down Syndrome (DS) | Completed | Cairo University | 240 | 2025-04-05 | 2025-09-08 | |
| Pediatric Down Syndrome Post-Approval Study Hypoglossal Nerve Stimulation - Pediatric Obstructive Sleep Apnea, Down Syndrome (DS) | Not applicable | Recruiting | Inspire Medical Systems, Inc. | 60 | 2025-02-01 | 2025-02-28 |
| Suspension Therapy Effects on Mobility and Balance in Down Syndrome suspension Therapy, Routine Treatment - Down Syndrome (DS) | Not applicable | Recruiting | Riphah International University | 26 | 2024-09-24 | 2024-12-27 |
| Using Technologies to Promote HEalthy Lifestyles in Adolescents With Intellectual Disabilities mHealth - Intellectual Disabilities (F70-F79), Down Syndrome (DS) | Not applicable | Recruiting | University of Seville | 60 | 2024-01-01 | 2025-08-07 |
| Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool Epigallocatechin-3-gallate (EGCG) - Down Syndrome (DS) | Phase 2 | Completed | Parc de Salut Mar | 87 | 2012-02-01 | 2016-02-11 |
Down Syndrome (15) · Alzheimer Disease (4) · Motor Activity (2) · Autistic Disorder (1) · Bone Diseases, Metabolic (1) · Corneal Diseases (1) · Dementia (1) · Epilepsy (1) · Epilepsy, Tonic-Clonic (1) · Genetic Diseases, Inborn (1) · Intellectual Disability (1) · Keratoconus (1) · Leukemia, Myeloid, Acute (1) · Plaque, Amyloid (1) · Sedentary Behavior (1)
Abnormalities, Multiple (15) · Chromosome Disorders (15) · Congenital Abnormalities (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (15) · Nervous System Diseases (15) · Neurobehavioral Manifestations (15) · Neurologic Manifestations (15) · Genetic Diseases, Inborn (14) · Intellectual Disability (14) · Mental Disorders (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Neurocognitive Disorders (4) · Neurodegenerative Diseases (4) · Tauopathies (4)
Corneal Cross-Linking (1) · Cytarabine (1) · Daunorubicin (1) · Dietary Supplements (1) · Drug Delivery Systems (1) · Etoposide (1) · Idarubicin (1) · Levetiracetam (1) · Nutrition Assessment (1) · Telemedicine (1) · donanemab (1) · epigallocatechin gallate (1)
Cairo University (2) · Ankara University (1) · Brigham and Women's Hospital (1) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Inspire Medical Systems, Inc. (1) · Izgi Miray Demirbag (1) · Michael Rafii, MD, PhD (1) · Parc de Salut Mar (1) · Riphah International University (1) · Universidad de Burgos (1) · University of Kansas Medical Center (1) · University of Seville (1) · Woolfson Eye Institute (1)
Spain (4) · United States (4) · Egypt (2) · Turkey (Türkiye) (2) · Pakistan (1) · Russia (1)
Amy Bodde, PhD (1) · Maya G Aly, Assistant Professor (1) · Michael Rafii, MD, PhD (1) · Shalender K Bhasin, MB, BS (1) · Sidra Rukhsar, MS (1)
KL2TR002367 (1), R33AG066543 (1)