35 completed, 19 unknown, 12 recruiting, 5 active not recruiting. 69 Not applicable, 3 Phase 1, 2 Phase 2, 1 Early Phase 1, 1 Phase 3.
Follow Distress, Emotional: new trials by email Literature Review of Distress, Emotional trials Research Report on Distress, Emotional
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Virtual Communication in the Hospital: Impact on Patients and Surrogates VCHIPS - Communication, Anxiety | Not applicable | Withdrawn | Indiana University | 2027-03-31 | 2026-04-22 | |
| Hand in Hand: Feasibility of a Compassion-Focused App to Support Parents of Children With Mental Health Problems App-based Compassion Program - Physiological Conditions, Distress, Emotional | Not applicable | Not yet recruiting | University of Aarhus | 400 | 2026-11-01 | 2026-09-25 |
| AI-DBT For Serious Illness AI DBT - Serious Illness, Distress, Emotional | Phase 1 | Not yet recruiting | Rutgers, The State University of New Jersey | 80 | 2026-10-01 | 2026-08-05 |
| A Scalable Trans Diagnostic Intervention Targeting Adolescent Agency Supported by Conversational AI (AGENCIA) AGENCIA Digital Self-Guided, AGENCIA In-person With Digital Assistant - Irritability, Neurodevelopmental Disorders | Not applicable | Not yet recruiting | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 465 | 2026-04-01 | 2026-04-30 |
| Indigenous Youth and Young Adults With Diabetes Peer Mentorship Program Peer mentoring - Diabetes Mellitus, Distress, Emotional | Not applicable | Enrolling by invitation | McGill University Health Centre/Research Institute of the McGill University Health Centre | 40 | 2025-11-01 | 2026-10-15 |
| Readiness and Progress in Emotion Regulation Therapy Emotion Regulation Therapy via Telehealth - Rumination, Worry | Not applicable | Recruiting | Teachers College, Columbia University | 36 | 2025-10-24 | 2026-10-20 |
| Supportive Psychoeducational Intervention for Patients With Brain Tumors (Acceptance and Commitment Therapy-based Supportive Intervention for Patients With Central Nervous System Tumors) Psychosocial intervention, Usual supportive care - Malignant Brain Tumor, Glioma | Not applicable | Recruiting | Massachusetts General Hospital | 100 | 2025-05-15 | 2026-10-07 |
| Universally Delivered Interventions for Young People Behavioral Activation - single session intervention (BA-SSI), 4-session Mindset intervention - Distress, Emotional | Not applicable | Not yet recruiting | Pakistan Institute of Living and Learning | 564 | 2025-05-01 | 2024-12-10 |
| WHO Psychological Interventions for Mental Health Outcomes in Migrants Resettled in Italy: the ADVANCE Trial Experimental: Self-Help Plus and booster session, Doing What Matters in Times of Stress and booster session, Psychological Placebo - Distress, Psychological, Distress, Emotional | Not applicable | Recruiting | Universita di Verona | 237 | 2025-04-09 | 2025-10-06 |
| Treating Psychosocial Distress in Glaucoma Acceptance commitment therapy - Glaucoma, Primary Open Angle, Distress, Emotional | Not applicable | Completed | Duke University | 28 | 2025-04-01 | 2026-03-18 |
| Evaluating the Feasibility of a School-based Stepped Care Program for Internalizing Symptoms in Adolescents in Pakistan Enhanced School Mental Health Program (eSMHP) - Depression, Anxiety, Distress, Emotional | Not applicable | Completed | Global Institute of Human Development | 137 | 2025-03-28 | 2026-09-18 |
| Stress Management for College Students Virtual Sequential Emotional Processing Task, Virtual Control Task - Distress, Emotional | Not applicable | Recruiting | Boise State University | 500 | 2025-02-18 | 2025-03-21 |
| The Effect of Immersive Virtual Reality and Relaxing Videos on Lung Cancer Patients Immersive Virtual Reality, Relaxing Videos - Lung Cancer, Chemotherapy Effect | Not applicable | Completed | Hacettepe University | 315 | 2025-01-15 | 2026-09-18 |
| Heating Pad for in Office Cystoscopy and Urodynamic Testing Electrical heating pad, Sham heating pad - Anxiety, Pain | Not applicable | Withdrawn | The University of Texas Health Science Center at San Antonio | 2025-01-01 | 2025-05-23 | |
| Piloting a School-Based Distress Tolerance Skills Program for Adolescents Distress Tolerance Skills Training - Distress, Emotional, Internalizing Mental Health Symptoms | Not applicable | Completed | Oregon Health and Science University | 74 | 2024-10-25 | 2026-10-19 |
| Targeting Components of Distress Tolerance Self-Efficacy, Willingness, Psychoeducation - Distress, Emotional | Not applicable | Recruiting | University of Arkansas, Fayetteville | 240 | 2024-10-03 | 2025-07-10 |
| Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART ReCharge, TakeCharge - Diabetes type1, Diabetes Mellitus, Type 1 | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 200 | 2024-10-01 | 2025-10-29 |
| Impact of Dental Desensitization Facilitated by a Child Life Specialist Distress and Cooperation Dental Desensitization Clinic - Desensitization, Dental Anxiety | Completed | Children's Hospital Colorado | 60 | 2024-08-26 | 2026-06-29 | |
| The Effectiveness of E-health Intervention in Improving Mental Health Outcomes Among Breast Cancer Patients E-health video - Breast Cancer, Breast Neoplasms | Not applicable | Unknown | National University of Malaysia | 114 | 2024-08-09 | 2024-08-22 |
| Pilot of Pragmatic Delivery of Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes ReCharge, TakeCharge - Diabetes type1, Diabetes Mellitus, Type 1 | Not applicable | Completed | University of North Carolina, Chapel Hill | 12 | 2024-07-22 | 2024-12-05 |
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Anxiety Disorders (27) · Depression (23) · COVID-19 (7) · Neoplasms (7) · Emotional Regulation (6) · Pain (5) · Diabetes Mellitus (4) · Psychological Well-Being (4) · Burnout, Psychological (3) · Diabetes Mellitus, Type 1 (3) · Fatigue (3) · Rumination Syndrome (3) · Suicide (3) · Breast Neoplasms (2) · Infertility (2)
Behavior (42) · Behavioral Symptoms (34) · Mental Disorders (30) · Pathological Conditions, Signs and Symptoms (12) · Neurologic Manifestations (10) · Signs and Symptoms (10) · Lung Diseases (8) · Respiratory Tract Diseases (8) · Coronaviridae Infections (7) · Coronavirus Infections (7) · Infections (7) · Nervous System Diseases (7) · Nidovirales Infections (7) · Pneumonia (7) · Pneumonia, Viral (7)
Therapeutics (3) · Acceptance and Commitment Therapy (2) · Autogenic Training (1) · Balneology (1) · Caregivers (1) · Coping Skills (1) · Dexmedetomidine (1) · Entonox (1) · Ethanol (1) · Health Personnel (1) · Kombucha Tea (1) · Methods (1) · Midazolam (1) · Nitrous Oxide (1) · Palliative Care (1)
Teachers College, Columbia University (4) · Massachusetts General Hospital (3) · Danish Cancer Society (2) · Duke University (2) · Harvard University (2) · Ottawa Hospital Research Institute (2) · Rutgers, The State University of New Jersey (2) · The University of Hong Kong (2) · Unity Health Toronto (2) · University of Aarhus (2) · University of North Carolina, Chapel Hill (2) · University of Regina (2) · University of Wisconsin, Madison (2) · Alexandria University (1) · Arizona State University (1)
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Anna Kahkoska, MD, PhD (2) · Douglas S Mennin (2) · Venkat Bhat, MD MSc (2) · Alex Hofer, Dr. (1) · Alexandra R. Levit (1) · Alexia M Torke, MD (1) · Andrea Poli, Psy.D. (1) · Andrew B Newberg (1) · Azmawati Mohammed Nawi (1) · Bonnie Nagel, PhD (1) · Caroline S Dorfman, PhD (1) · Corrado Barbui, MD, Full professor (1)
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