4 completed, 2 recruiting, 2 terminated, 1 active not recruiting. 4 Not applicable, 2 Phase 2, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 3, Recruiting 1 |
| Phase 2 | 2 | Active not recruiting 1, Terminated 1 |
| Phase 3 | 2 | Active not recruiting 1, Recruiting 1 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
Follow Entonox: new trials by email Literature Review of Entonox trials Research Report on Entonox
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nitrous Oxide and EMOtional Cognition Entonox, Medical Air - Depression | Not applicable | Recruiting | University of Oxford | 88 | 2024-07-10 | 2025-07-31 |
| Anxiolysis for Laceration Repair in Children Dexmedetomidine, Midazolam Nasal Spray, Nitrous oxide - Laceration of Skin, Distress, Emotional | Phase 3 | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 300 | 2023-12-19 | 2025-04-30 |
| The Effect of Entonox on Stages of Labor in Nulliparous Women Entonox, Not receive Entonox - ENTONOX, Nulliparous | Not applicable | Completed | Department of Medical Services Ministry of Public Health of Thailand | 80 | 2019-11-01 | 2024-12-03 |
| CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery) Epidural delivery system, Entonox, Meperidine - Depression, Postpartum, Analgesia, Obstetrical | Phase 2 / Phase 3 | Active not recruiting | KK Women's and Children's Hospital | 881 | 2017-06-15 | 2026-08-06 |
| Nitrous Oxide Use in Minor Procedures Nitrous Oxide - Laceration, Abscess | Not applicable | Completed | New York City Health and Hospitals Corporation | 82 | 2013-07-01 | 2016-04-11 |
| A Single-centre Study of Entonox Versus Midazolam Sedation in Gastroscopy Entonox, Midazolam - Patients Requiring Diagnostic Gastroscopy With Sedation | Phase 4 | Terminated | The Royal Bournemouth Hospital | 62 | 2013-05-01 | 2024-11-12 |
| Optimizing the Use of Entonox® During Screening Colonoscopy Entonox - Bowel Cancer Screening, Analgesia | Phase 4 | Completed | Sheffield Teaching Hospitals NHS Foundation Trust | 100 | 2013-01-01 | 2019-09-23 |
| Inhaled Nitrous Oxide and Labor Analgesia Inhaled nitrous oxide - Labor Pain | Phase 2 | Terminated | Ya'aqov Abrams | 16 | 2012-02-01 | 2017-11-21 |
| Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients Entonox, Oxygen - Low Back Pain, Radiating Pain | Not applicable | Completed | The Cleveland Clinic | 78 | 2011-01-01 | 2016-10-17 |
Agnosia (3) · Pain (2) · Abscess (1) · Anxiety Disorders (1) · Depression (1) · Depression, Postpartum (1) · Disease (1) · Labor Pain (1) · Lacerations (1) · Low Back Pain (1)
Department of Medical Services Ministry of Public Health of Thailand (1) · KK Women's and Children's Hospital (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · New York City Health and Hospitals Corporation (1) · Sheffield Teaching Hospitals NHS Foundation Trust (1) · The Cleveland Clinic (1) · The Royal Bournemouth Hospital (1) · University of Oxford (1) · Ya'aqov Abrams (1)
United Kingdom (3) · United States (3) · Canada (1) · Singapore (1) · Thailand (1)
Alparslan Turan, M.D. (1) · Ban Leong Sng, FANZCA (1) · Sandra Cunningham, MD (1) · Simon McLaughlin, MD (1) · Stuart A Riley, MB ChB (1) · Ya'aqov Abrams, MD (1)
PMID 25629571, PMID 37491196, PMID 37990597, PMID 39732915, PMID 40113655, PMID 40465577, PMID 40775649, PMID 42049811, PMID 42092800, PMID 42314868