4768 completed, 1774 unknown, 1344 recruiting, 1252 terminated. 10712 Phase 2, 1993 Phase 1, 735 Phase 3.
Follow Digestive System Diseases: new trials by email Literature Review of Digestive System Diseases trials Research Report on Digestive System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Certepetide Phase 1b/2a Continuous Infusion Trial in mPDAC certepetide, nab-paclitaxel, gemcitabine - Pancreas Cancer, Pancreatic Carcinoma | Phase 1 / Phase 2 | Withdrawn | Lisata Therapeutics, Inc. | 2030-01-01 | 2025-06-06 | |
| The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp Shared Decision Making using a Patient Decision Aid. - Shared Decision Making, Colonic Polyp | Phase 2 | Not yet recruiting | Vejle Hospital | 110 | 2028-02-01 | 2026-04-30 |
| The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction Caloric Restriction, Hyperglycemic clamp - Type2diabetes | Phase 2 | Not yet recruiting | Adrian Vella | 20 | 2027-12-15 | 2026-10-28 |
| CA102N Combined With TAS-102 Compared to Bevacizumab Combined With TAS-102 in Subjects With Metastatic Colorectal Cancer CA102N, TAS-102, Bevacizumab - Metastatic Colorectal Cancer | Phase 2 | Suspended | Holy Stone Healthcare Co., Ltd | 100 | 2027-12-01 | 2026-09-18 |
| Oral Fosamprenavir for GERD Fosamprenavir Calcium 700 MG Oral Tablet, Placebo - Refractory Gastroesophageal Reflux Disease, Gastroesophageal Reflux Disease | Phase 2 | Not yet recruiting | Medical College of Wisconsin | 60 | 2027-10-01 | 2026-09-10 |
| Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome Shuganhuazhuo Formula, Targeted therapy, Immunotherapy - HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine | Phase 2 | Not yet recruiting | Xiang-Qian | 120 | 2027-09-01 | 2026-08-27 |
| Ampligen Combined With SOC Versus SOC Alone Following First-Line Therapy in Subjects With LAPC Rintatolimod - Pancreatic Cancer | Phase 2 | Suspended | AIM ImmunoTech Inc. | 90 | 2027-08-01 | 2026-08-19 |
| Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation DN022150+AG( Stage I ）, DN022150+AG（Stage II）, placebo+AG（Stage II） - Pancreatic Cancer, Pancreatic Carcinoma | Phase 2 / Phase 3 | Not yet recruiting | Jiangxi Kvvit Pharmaceutical Co., Ltd. | 465 | 2027-06-06 | 2026-06-18 |
| Multicenter Phase 2 Study of Envafolimab in Biliary Tract Cancers Envafolimab plus Gemcitabine&Cisplatin, Gemcitabine&Cisplatin - Biliary Tract Neoplasms | Phase 2 | Not yet recruiting | 3D Medicines (Sichuan) Co., Ltd. | 126 | 2027-06-01 | 2026-03-25 |
| Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a (Trastuzumab Deruxtecan), for Advanced Pancreatic Ductal Adenocarcinoma Biospecimen Collection, Diagnostic Imaging Testing, Echocardiography Test - Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 31 | 2027-06-01 | 2026-10-22 |
| Immunotherapy Treating GI Cancer engineered immune cells - Cancer | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 100 | 2027-06-01 | 2026-11-02 |
| Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial Balstilimab, Biopsy Procedure, Biospecimen Collection - Colorectal Adenocarcinoma, Stage II Colorectal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 20 | 2027-05-25 | 2026-09-29 |
| SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease Empagliflozin 10 MG, Placebo Oral Tablet - Non-Alcoholic Fatty Liver Disease, NAFLD | Phase 2 | Not yet recruiting | Justin Ryder | 40 | 2027-05-01 | 2026-01-20 |
| PET/MRI in Rectal Cancer Total Neo-adjuvant Therapy, 18FDG-PET/MRI scan - Rectal Cancer | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 40 | 2027-05-01 | 2026-10-28 |
| A Phase I/IIa Study of EF-009 in Patients With Pancreatic Cancer EF-009 - Pancreatic Cancer | Phase 1 / Phase 2 | Not yet recruiting | Everfront Biotech Co., Ltd. | 30 | 2027-04-01 | 2026-09-11 |
| Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH). TRA16, Placebo - Enteric Hyperoxaluria | Phase 2 | Not yet recruiting | Wuhan Kangfude Urolithiasis Research Institute Co., Ltd. | 30 | 2027-03-01 | 2026-10-13 |
| A Clinical Study Evaluating the Safety and Efficacy of Ivonescimab as Second-line Treatment in Patients With Advanced Hepatocellular Carcinoma Ivonescimab - Hepatocellular Carcinoma (HCC), HCC - Hepatocellular Carcinoma | Phase 2 | Not yet recruiting | MedSIR | 44 | 2027-03-01 | 2026-11-04 |
| Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer Cemiplimab + Fianlimab [Fixed Dose Combination (FDC)] - Colon Cancer | Phase 2 | Not yet recruiting | John Strickler, M.D. | 24 | 2027-03-01 | 2026-11-05 |
| Stereotactic Body Radiation Therapy (SBRT) and Immunotherapy for Oligometastatic Esophageal Cancer Stereotactic body radiation treatment (SBRT) - Esophageal Cancer | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 22 | 2027-03-01 | 2026-10-28 |
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
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Colorectal Neoplasms (1873) · Pancreatic Neoplasms (1253) · Carcinoma, Hepatocellular (1112) · Stomach Neoplasms (1084) · Rectal Neoplasms (714) · Esophageal Neoplasms (614) · Colonic Neoplasms (603) · Neoplasm Metastasis (406) · Neoplasms (373) · Esophageal Squamous Cell Carcinoma (353) · Non-alcoholic Fatty Liver Disease (349) · Liver Neoplasms (346) · Colitis, Ulcerative (345) · Hepatitis C (339) · Crohn Disease (315)
Digestive System Neoplasms (6984) · Neoplasms by Site (6967) · Neoplasms (6803) · Gastrointestinal Diseases (5954) · Gastrointestinal Neoplasms (4292) · Intestinal Diseases (3717) · Liver Diseases (2803) · Colonic Diseases (2681) · Intestinal Neoplasms (2603) · Rectal Diseases (2432) · Neoplasms by Histologic Type (2310) · Neoplasms, Glandular and Epithelial (2077) · Carcinoma (1907) · Pathological Conditions, Signs and Symptoms (1906)
Oxaliplatin (841) · Fluorouracil (731) · Capecitabine (630) · Gemcitabine (562) · Leucovorin (523) · Bevacizumab (513) · Irinotecan (482) · Cisplatin (406) · Radiotherapy (322) · Cetuximab (300) · pembrolizumab (252) · Paclitaxel (236) · Ribavirin (232) · Nivolumab (204) · Docetaxel (192)
National Cancer Institute (NCI) (264) · Sun Yat-sen University (175) · Fudan University (169) · Gilead Sciences (116) · M.D. Anderson Cancer Center (116) · GlaxoSmithKline (97) · Memorial Sloan Kettering Cancer Center (88) · Tianjin Medical University Cancer Institute and Hospital (87) · Bristol-Myers Squibb (84) · Merck Sharp & Dohme LLC (81) · Hoffmann-La Roche (80) · AstraZeneca (74) · Eli Lilly and Company (70) · Novartis Pharmaceuticals (70) · Mayo Clinic (69)
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Tim F Greten, M.D. (16)
PMID 35623069, PMID 33331662, PMID 37983082, PMID 39863139, PMID 36318027, PMID 32671834, PMID 33538338, PMID 15496622, PMID 28712102, PMID 37934000, PMID 40340830, PMID 19192962, PMID 21561347, PMID 22646630, PMID 26808342, PMID 30642373, PMID 31401903, PMID 32251400, PMID 34143971, PMID 36852452, PMID 38592721, PMID 12049862, PMID 19097774, PMID 20375404, PMID 22473314, PMID 26187751, PMID 26313683, PMID 26884585, PMID 27602924, PMID 28193518, PMID 28223062, PMID 28434648, PMID 30012435, PMID 30207593, PMID 30664876, PMID 30721964, PMID 30923816, PMID 30977945, PMID 31215818, PMID 32716739, PMID 32816630, PMID 33198671, PMID 35660797, PMID 36511181, PMID 36529152, PMID 36657089, PMID 36990609, PMID 37011138, PMID 37598000, PMID 39326675
2023 (96), 2016 (79), 2017 (76), 2019 (74), 2015 (62), 2014 (61), 2025 (61), 2018 (58), 2009 (50), 2008 (41), P30CA015083 (26), P30CA016672 (24), U10CA032102 (22), P30CA033572 (16), P30CA060553 (16)