30 completed, 1 active not recruiting, 1 not yet recruiting, 1 unknown. 12 Not applicable, 10 Phase 3, 9 Phase 2, 4 Phase 1, 2 Phase 4.
Follow Diarrhoea: new trials by email Literature Review of Diarrhoea trials Research Report on Diarrhoea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-Term Immunogenicity of the altSonflex1-2-3 Shigella Vaccine in African Children AltSonflex1-2-3, Menveo, Infanrix hexa - Diarrhoea | Phase 2 | Not yet recruiting | GlaxoSmithKline | 528 | 2026-01-02 | 2026-01-06 |
| CMTS4520 for Chronic Diarrhoea in Adults CMTS4520 (dietary fiber and probiotics), Placebo - Diarrhoea | Phase 1 / Phase 2 | Active not recruiting | The Second Hospital of Nanjing Medical University | 100 | 2025-02-20 | 2025-11-18 |
| A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants altSonflex1-2-3 Dose A, altSonflex1-2-3 Dose B, altSonflex1-2-3 Dose C - Diarrhoea | Phase 2 | Completed | GlaxoSmithKline | 200 | 2024-11-13 | 2026-01-30 |
| Racecadotril Versus Standard Treatment in Decreasing the Duration of Acute Diarrhoea in Children Racecadotril - Diarrhoea | Phase 1 / Phase 2 | Completed | Benazir Bhutto Hospital, Rawalpindi | 260 | 2024-08-02 | 2026-09-22 |
| A Study Based on Medical Records in Spain That Looks at Diarrhoea Control in People With Pulmonary Fibrosis Who Are Taking Nintedanib Nintedanib - Idiopathic Pulmonary Fibrosis, Diarrhoea | Completed | Boehringer Ingelheim | 18 | 2024-07-16 | 2026-05-13 | |
| A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants AltSonflex1-2-3 High Dose, AltSonflex1-2-3 Medium Dose, AltSonflex1-2-3 Low Dose - Diarrhoea | Phase 1 / Phase 2 | Completed | GlaxoSmithKline | 551 | 2021-10-06 | 2026-06-22 |
| Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda BCG at birth, Control arm: Delayed BCG - Severe Illness, Septicaemia | Phase 3 | Completed | Makerere University | 4500 | 2016-07-01 | 2025-03-04 |
| Reformulated F75 Milk to Treat Severe Acute Malnutrition Standard F75 Milk, Modified F75 Milk - Malnutrition, Diarrhoea | Phase 2 / Phase 3 | Completed | University of Oxford | 842 | 2014-12-01 | 2016-04-14 |
| The Effect of Enteral Nutrition Supplemented With Prebiotics on Colonic Microbiota in the Critically Ill Patients Prebiotics-free enteral formula, Prebiotics containing enteral formula - Diarrhoea | Not applicable | Unknown | University of Malaya | 40 | 2014-01-01 | 2014-05-21 |
| Safety and Efficacy of IQP-MM-101 in Reducing Symptoms of Diarrhoea IQP-MM-101 - Diarrhoea | Not applicable | Completed | InQpharm Group | 101 | 2013-10-01 | 2020-03-04 |
| ICCM of Common Childhood Diseases: Mozambique and Uganda Technology supported supervision, Community supported supervision, Integrated community case management - Malaria, Pneumonia | Not applicable | Completed | Malaria Consortium | 2289 | 2013-04-01 | 2016-01-08 |
| Improving the Diagnosis of Diarrhoea in Emergency Rooms Nasopharyngeal Swab - Diarrhoea | Not applicable | Completed | Assistance Publique Hopitaux De Marseille | 354 | 2013-03-20 | 2023-04-21 |
| Strengthening Maternal Neonatal and Child Health Services in a Rural District of Pakistan Maternal Neonatal and Child Health Interventions - Antepartum Hemorrhage, Postpartum Hemorrhage | Not applicable | Completed | Aga Khan University | 15000 | 2013-01-01 | 2020-06-22 |
| A Study to Evaluate the Effect and Safety of Idoform Plus on Bowel Side Effects in Healthy Subjects Treated With Amoxicillin/ Clavulanate Idoform Plus, Placebo - Diarrhoea | Phase 4 | Withdrawn | Pfizer | 2013-01-01 | 2013-09-24 | |
| Causes of Rotavirus Vaccine Failure in Zambian Children Diarrhoea | Completed | Centre for Infectious Disease Research in Zambia | 420 | 2012-04-01 | 2018-08-23 | |
| Can Mass Media Campaigns Reduce Child Mortality Local radio campaign to reduce under-five child mortality - Diarrhoea, Malaria | Not applicable | Completed | London School of Hygiene and Tropical Medicine | 100000 | 2012-03-01 | 2015-05-20 |
| Effectiveness of Nutritional Supplementation in Preventing Malnutrition in Children With Infection Ready to Use Therapeutic Food (RUTF), Micronutrient Powder (MNP) - Malnutrition, Malaria | Not applicable | Completed | Medecins Sans Frontieres, Netherlands | 2213 | 2012-02-01 | 2013-10-16 |
| Effects of Bolus and Continuous Nasogastric Feeding on Small Bowel Water Content and Blood Flow NG bolus feeding over 5 min, Continuous NG feeding over 4 h - Enteral Feeding, Nasogastric Feeding | Phase 1 / Phase 2 | Completed | University of Nottingham | 12 | 2012-01-01 | 2013-05-06 |
| An Efficacy Trial of a Gravity Fed Household Water Treatment Device as a Delivery System for Zinc Zinc enriched water - Diarrhoea | Not applicable | Completed | Wageningen University | 270 | 2011-08-01 | 2014-02-28 |
| Study of Alternative Vaccination Schedule of Oral Cholera Vaccine Modified killed oral cholera vaccine at 14 day interval, Modified killed oral cholera vaccine at 28 day interval - Cholera, Diarrhoea | Phase 2 | Completed | International Vaccine Institute | 386 | 2010-12-01 | 2013-09-25 |
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Diarrhea (34) · Malaria (4) · Pneumonia (4) · Malnutrition (3) · Dysentery, Bacillary (2) · Gastroenteritis (2) · Anemia (1) · Asphyxia Neonatorum (1) · Body Weight (1) · Breast Feeding (1) · Cachexia (1) · Cholera (1) · Convalescence (1) · Disease (1) · Dysentery (1)
Pathological Conditions, Signs and Symptoms (34) · Signs and Symptoms (34) · Signs and Symptoms, Digestive (34) · Infections (10) · Digestive System Diseases (5) · Gastrointestinal Diseases (5) · Lung Diseases (5) · Respiratory Tract Diseases (5) · Mosquito-Borne Diseases (4) · Nutritional and Metabolic Diseases (4) · Parasitic Diseases (4) · Protozoan Infections (4) · Respiratory Tract Infections (4) · Vector Borne Diseases (4) · Bacterial Infections (3)
diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (3) · Duration of Therapy (2) · Hepatitis B Vaccines (2) · Meningococcal Vaccines (2) · Probiotics (2) · Smectite (2) · Tetanus Toxoid (2) · smecta (2) · Boostrix (1) · Dietary Fiber (1) · Lacteol (1) · Lactose (1) · Osmolite (1) · Rifaximin (1) · Rubella Vaccine (1)
GlaxoSmithKline (4) · International Centre for Diarrhoeal Disease Research, Bangladesh (3) · London School of Hygiene and Tropical Medicine (3) · Ipsen (2) · Aga Khan University (1) · Assistance Publique Hopitaux De Marseille (1) · Benazir Bhutto Hospital, Rawalpindi (1) · Boehringer Ingelheim (1) · Centre for Infectious Disease Research in Zambia (1) · Dr. Philipp Zanger, MD MSc DTM (1) · InQpharm Group (1) · International Vaccine Institute (1) · Makerere University (1) · Malaria Consortium (1) · Medecins Sans Frontieres, Netherlands (1)
Kenya (5) · Bangladesh (3) · India (3) · United Kingdom (3) · Germany (2) · Malaysia (2) · Uganda (2) · Belgium (1) · Brazil (1) · Burkina Faso (1) · Cambodia (1) · China (1) · Denmark (1) · France (1) · Malawi (1)
Nur H Alam, MD (2) · Thomas Clasen, PhD (2) · Abeed H Chowdhury, BSc MRCS (1) · Amit Saha, MBBS (1) · Chakravarthi Rajkumar (1) · Diego Moretti, PhD (1) · Dipika Sur, MD, DPH (1) · Faming Zhang, PhD (1) · Halvor Sommerfelt, MD, PhD (1) · Hazreen Abdul Majid, BSc(RD),PhD (1) · James A Berkley (1) · Kevin G McGuigan, PhD (1)
PMID 20237063, PMID 21936492, PMID 23602437, PMID 23618760, PMID 23976883, PMID 24012319, PMID 25084699, PMID 25442689, PMID 25684587, PMID 26315661, PMID 26859559, PMID 27496512, PMID 28511653, PMID 29433668, PMID 30057798, PMID 30807589, PMID 31775877, PMID 33154417, PMID 33565123, PMID 34538239, PMID 35987625, PMID 37307519, PMID 38853614
R01AI099601 (1)