56 completed, 19 unknown, 17 not yet recruiting, 12 active not recruiting. 119 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 119 | Completed 56, Unknown 19, Not yet recruiting 17, Active not recruiting 12, Recruiting 10, Enrolling by invitation 4, Suspended 1 |
Follow Developmental Defects of Enamel: new trials by email Literature Review of Developmental Defects of Enamel trials Research Report on Developmental Defects of Enamel
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Ain Shams University | 45 | 2027-05-01 | 2026-09-17 |
| Esthetic Impact of Different Minimally Invasive Approaches on Hypomineralized Permanent Anterior Teeth ICON® resin infiltration, Opalustre® enamel microabrasion, Antivet® enamel micro-abrasion - Enamel Hypomineralization, Dental | Not applicable | Not yet recruiting | Shaimaa Abdelrahman | 69 | 2027-01-01 | 2026-11-05 |
| Clinical Performance of Glass Hybrid and Alkasite Restorative Systems in MIH-Affected Permanent First Molars Alkasite Restorative System, Glass Hybrid Restorative System - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Çanakkale Onsekiz Mart University | 30 | 2026-12-31 | 2026-10-30 |
| Risk of Caries and Enamel Abnormalities in Patients With Cleft Palate Clinical oral examination and standardised questionnaires - Dental Caries | Not applicable | Not yet recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 400 | 2026-12-14 | 2026-11-09 |
| Direct Composite Versus Indirect Hybrid Resin Restorations in Hypomineralized First Permanent Molars 3d printed restoration, composite - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Cairo University | 40 | 2026-10-01 | 2026-07-21 |
| Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor Hypomineralization Computer-Controlled Local Anesthesia, Conventional Local Anesthesia - Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Marmara University | 54 | 2026-08-11 | 2026-07-29 |
| Aesthetic Masking and Resin Infiltration Time in MIH-affected Incisors macroabrasion followed by oxidative pretreatment, macroabrasion alone - Molar Incisor Hypomineralization | Not applicable | Not yet recruiting | Alexandria University | 100 | 2026-08-10 | 2026-08-07 |
| Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions Sodium hypochlorite 5.25%, CPP-ACPF - Molar Incisor Hypomineralization | Not applicable | Not yet recruiting | Universidade Ceuma | 54 | 2026-08-01 | 2026-07-08 |
| The Effectiveness of Antivet Versus Opalustre® for the Management of Enamel Fluorosis/Discolored Enamel and Its Impact on Aesthetic Outcomes. Antivet, Opalusture - Fluorosis, Dental, Enamel Discoloration | Not applicable | Completed | October University for Modern Sciences and Arts | 59 | 2026-05-18 | 2026-07-16 |
| Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization Glass Hybrid Restorative Treatment - Molar-Incisor Hypomineralization (MIH), Masticatory Performance | Not applicable | Not yet recruiting | Marmara University | 68 | 2026-05-11 | 2026-06-04 |
| Pain Assessment Governing Partial or Full Pulpotomy of Immature Molars With Irreversible Pulpitis in Molar Incisor Hypomineralization pulpotomy for MIH affected immature PFMs, partial pulpotomy for MIH affected immature PFMs, pulpotomy for non-MIH affected immature PFMs - Molar Incisor Hypomineralisation, Irreversible Pulpitis | Not applicable | Active not recruiting | Alaa Khafagy | 132 | 2026-05-01 | 2026-10-01 |
| Total Pulpotomy With Two Repair Cements in Hypomineralized Teeth MTA group, CIMMO DTA® group - Molar-Incisor Hypomineralization (MIH) | Not applicable | Active not recruiting | Meire Coelho Ferreira | 120 | 2026-04-16 | 2026-08-20 |
| Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars Standard Local Anesthesia, Intraoral Cryotherapy, Silver Diamine Fluoride (SDF) - MIH, Molar-Incisor Hypomineralization | Not applicable | Not yet recruiting | Çanakkale Onsekiz Mart University | 75 | 2026-02-01 | 2026-01-08 |
| Preemptive Analgesia for Pain and Anxiety Control in Children With MIH ibuprofen 100mg/ml oral suspension syrup, Placebo - Pain and Anxiety in Children With MIH | Not applicable | Recruiting | October University for Modern Sciences and Arts | 46 | 2026-02-01 | 2026-01-28 |
| The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical Trial Salvadora persica (miswak), Fluoridated Toothpaste - Molar Incisor Hypomineralisation | Not applicable | Not yet recruiting | King Abdulaziz University | 30 | 2026-01-29 | 2026-01-21 |
| Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study Graphene-reinforced CAD/CAM polymer (G-CAM®) - Tooth Demineralization, Tooth Sensitivity | Not applicable | Not yet recruiting | Universitat Internacional de Catalunya | 30 | 2026-01-10 | 2026-01-09 |
| Impact of Glass-Hybrid Restoration on Occlusal Force Distribution and Masticatory Muscle Activity in Children With Molar-Incisor Hypomineralization Glass-Hybrid Restoration - Molar-Incisor Hypomineralization (MIH) | Not applicable | Completed | Marmara University | 5 | 2026-01-05 | 2026-05-12 |
| Zirconia and Bioflx Crowns for Primary Anterior Teeth Zirconia Crown, Bioflx Crown - Dental Caries, Tooth Hypomineralization | Not applicable | Active not recruiting | Hue University of Medicine and Pharmacy | 120 | 2026-01-04 | 2026-07-09 |
| Nanohydroxyapatite Versus Sodium Fluoride Varnish in Remineralizing MIH Anterior Teeth Nanohydroxyapatite Varnish Application, Sodium Fluoride Varnish Application - Fluoride Varnishes, Molar Incisor Hypomineralisation | Not applicable | Recruiting | Tanta University | 26 | 2026-01-03 | 2026-10-26 |
| Er:YAG Laser Versus Conventional Cavity Preparation in Children With Molar-Incisor Hypomineralization Er:YAG Laser-Assisted Cavity Preparation, Conventional Rotary Cavity Preparation - Molar-Incisor Hypomineralization (MIH) | Not applicable | Active not recruiting | Ege University | 52 | 2026-01-03 | 2026-08-12 |
Showing 20 of 119. Sign in to see all of them.
Molar Hypomineralization (91) · Dental Enamel Hypomineralization (13) · Fluorosis, Dental (12) · Dental Caries (11) · Dentin Sensitivity (9) · Dental Enamel Hypoplasia (6) · Hypersensitivity (6) · Toothache (5) · Amelogenesis Imperfecta (3) · Fluoride Poisoning (3) · Pain (3) · Tooth Erosion (3) · Dental Plaque (2) · Health Education (2) · Van der Woude syndrome (2)
Congenital Abnormalities (119) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (119) · Stomatognathic System Abnormalities (119) · Tooth Abnormalities (119) · Tooth Diseases (119) · Stomatognathic Diseases (118) · Dental Enamel Hypomineralization (101) · Tooth Demineralization (13) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (8) · Neurologic Manifestations (7) · Immune System Diseases (6) · Facial Pain (5) · Pain (4)
Enamel Microabrasion (3) · Low-Level Light Therapy (3) · Fluorides, Topical (2) · Laser Therapy (2) · Pulpotomy (2) · Toothpastes (2) · casein phosphopeptide-amorphous calcium phosphate nanocomplex (2) · opalustre (2) · Analgesia (1) · Anesthesia, Local (1) · Apexification (1) · Blood Specimen Collection (1) · Composite Resins (1) · Control Groups (1) · Dental Atraumatic Restorative Treatment (1)
Cairo University (9) · Marmara University (7) · Alexandria University (5) · Hacettepe University (5) · King Abdullah University Hospital (4) · Ain Shams University (3) · October University for Modern Sciences and Arts (3) · University of Pavia (3) · University of Sao Paulo (3) · Al-Azhar University (2) · Assistance Publique - Hôpitaux de Paris (2) · Baskent University (2) · Ege University (2) · Hue University of Medicine and Pharmacy (2) · Jordan University of Science and Technology (2)
Turkey (Türkiye) (27) · Egypt (24) · Brazil (10) · Jordan (6) · Italy (4) · France (3) · Mexico (3) · Syria (3) · United States (3) · Vietnam (3) · Belgium (2) · Colombia (2) · Spain (2) · Croatia (1) · Ethiopia (1)
Meire C. Ferreira, PhD (2) · Ola B. Al-Batayneh (2) · Abdulrhman S Hakmi (1) · Abeer Abd Elatiif, professor (1) · Abla A. Aly, Phd (1) · Agneta Robertson (1) · Aline Castilho, DDS (1) · Alp Abidin Atesci, PhD (1) · Andrea Scribante, Associate Professor (1) · Andrea Scribante, DDS, PhD (1) · Andrea Scribante, DDS, PhD. (1) · Arif Bolaca, Dr (1) · Aya Adl, Dr (1)
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