6 completed, 2 recruiting, 2 unknown, 1 terminated. 4 Not applicable, 1 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Recruiting 2, Completed 1, Unknown 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Terminated 1 |
| Phase 4 | 1 | Completed 1 |
Follow Depression Severe: new trials by email Literature Review of Depression Severe trials Research Report on Depression Severe
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Kintsugi Voice Device Pivotal Study Kintsugi Voice Device - Depression, Depression Moderate | Completed | Kintsugi Mindful Wellness, Inc. | 1600 | 2025-03-27 | 2026-08-14 | |
| Kintsugi Voice Device Pilot Study Kintsugi Voice Device - Depression, Depression Moderate | Completed | Kintsugi Mindful Wellness, Inc. | 262 | 2024-03-22 | 2026-08-14 | |
| Telehealth Behavioral Activation for Teens Behavioral Activation - Depression, Suicide and Self-harm | Not applicable | Recruiting | Baylor College of Medicine | 250 | 2024-03-01 | 2026-08-04 |
| Integrated Depression Care Integrated care - Depression Mild, Depression Moderate | Not applicable | Unknown | University Ghent | 150 | 2023-04-25 | 2024-06-06 |
| Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD) TNX-601 ER, Placebo - Depression, Depressive Disorder | Phase 2 | Completed | Tonix Pharmaceuticals, Inc. | 132 | 2023-03-02 | 2025-02-17 |
| Exercise Recovery From Persistent Depression: A Thematic Analysis Major Depressive Disorder, Depression Moderate | Completed | University of Nottingham | 12 | 2022-12-01 | 2026-05-07 | |
| Brain Stimulation for Severe Depression INTRACALVARIAL PREFRONTAL CORTICAL STIMULATION (IpCS) IN SEVERE TREATMENT-RESISTANT DEPRESSION - Depression Severe | Not applicable | Recruiting | Inner Cosmos Inc | 20 | 2022-07-28 | 2026-04-15 |
| The OPUS YOUNG Trial. Early Intervention Versus Treatment as Usual for Adolescents With First-episode Psychosis OPUS YOUNG, Treatment as Usual - Schizophrenia, Schizotypal Disorder | Not applicable | Completed | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | 284 | 2021-05-06 | 2026-08-20 |
| Outcomes Associated With Suicidality in Inpatients With Symptoms of Depression (OASIS-D) Depression, Depression Moderate | Unknown | Charite University, Berlin, Germany | 3331 | 2020-08-01 | 2024-02-07 | |
| A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Depression No Intervention - Depression, Clinical Depression | Withdrawn | ProgenaBiome | 2020-03-02 | 2025-06-05 | ||
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department Ketamine Hydrochloride, Normal saline - Suicide, Suicide Threat | Phase 3 | Terminated | Naval Medical Center Camp Lejeune | 1 | 2020-01-14 | 2025-05-14 |
| Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department Ketamine, Sodium Chloride 0.9% - Depression, Depression Severe | Phase 4 | Completed | MercyOne Des Moines Medical Center | 29 | 2019-10-18 | 2020-09-01 |
Depression (7) · Depressive Disorder, Major (3) · Suicide (3) · Depressive Disorder (2) · Self-Injurious Behavior (2) · Suicidal Ideation (2) · Anxiety Disorders (1) · Depression, Postpartum (1) · Emergencies (1) · Mental Disorders (1) · Motor Activity (1) · Psychoses, Substance-Induced (1) · Psychotic Disorders (1) · Schizophrenia (1) · Schizophrenia, Paranoid (1)
Behavior (9) · Behavioral Symptoms (8) · Mental Disorders (3) · Mood Disorders (3) · Self-Injurious Behavior (2) · Chemically-Induced Disorders (1) · Depressive Disorder (1) · Disease Attributes (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1) · Personality Disorders (1) · Poisoning (1) · Pregnancy Complications (1) · Puerperal Disorders (1)
Ketamine (2) · Saline Solution (2) · Delivery of Health Care, Integrated (1) · Sodium Chloride (1) · Therapeutics (1) · tianeptine (1)
Kintsugi Mindful Wellness, Inc. (2) · Baylor College of Medicine (1) · Charite University, Berlin, Germany (1) · Inner Cosmos Inc (1) · Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital (1) · MercyOne Des Moines Medical Center (1) · Naval Medical Center Camp Lejeune (1) · ProgenaBiome (1) · Tonix Pharmaceuticals, Inc. (1) · University Ghent (1) · University of Nottingham (1)
United States (8) · Belgium (1) · Denmark (1) · Germany (1) · United Kingdom (1)
Adnan Iqbal, MD (1) · Anne K Pagsberg, PhD (1) · Christoph U Correll, MD (1) · Eric Lenze, MD (1) · Gregory Sullivan, MD (1) · Kathryn Bress, PharmD (1) · Liesbeth Borgermans, PhD (1) · Lieven Annemans, PhD (1) · Nathan H Butler, DO (1) · Neil Nixon, BSc,MMedSci,MBBS,DM,FRCPsych (1) · Sabine Hazan, MD (1)