12 completed, 4 unknown, 3 recruiting, 1 not yet recruiting. 4 Not applicable, 1 Early Phase 1, 1 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 3, Unknown 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Agenesis of Corpus Callosum: new trials by email Literature Review of Agenesis of Corpus Callosum trials Research Report on Agenesis of Corpus Callosum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bioengineered Penile Tissue Constructs for Irreversibly Damaged Penile Corpora Autologous tissue engineered corpora - Urologic Diseases, Male Urogenital Diseases | Phase 1 | Not yet recruiting | Wake Forest University Health Sciences | 10 | 2026-10-01 | 2026-03-27 |
| A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756) Setmelanotide, Placebo - Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form | Phase 3 | Recruiting | Rhythm Pharmaceuticals, Inc. | 39 | 2025-09-23 | 2026-02-12 |
| Sleep Profile of Patients With Septo-optic Dysplasia Actigraphy, blood and salivary sample, and sleep evaluation - Septo-Optic Dysplasia, Agenesis of Corpus Callosum | Unknown | IRCCS National Neurological Institute "C. Mondino" Foundation | 45 | 2023-12-20 | 2024-02-15 | |
| Decision-making Process of Couples Confronted With Prenatal Diagnosis of an Isolated CCA Decision-making process - Corpus Callosum Agenesis | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 100 | 2021-10-22 | 2023-05-06 |
| Retrospective Study Using Next Generation Sequencing (NGS) on Biological Samples to Improve Genetic Counseling for Patients With Previously Explored Craniofacial Midline Defects. NGS - Holoprosencephaly | Completed | Rennes University Hospital | 33 | 2021-02-10 | 2021-12-07 | |
| Screening of Septo-optic Dysplasia During a Fetal Examination at 16-20 Weeks of Gestation Displaying optic chiasm for screening septooptic dysplasia - 2D Ultrasound, Cavum Septum Pellucidum | Not applicable | Completed | Gaziosmanpasa Research and Education Hospital | 52 | 2020-09-21 | 2023-02-08 |
| Whole Exome Sequencing in Prenatal Diagnosis of Agenesis of the Corpus Callosum whole exome sequencing (WES) - Fetal Agenesis of the Corpus Callosum (ACC) | Completed | Assistance Publique - Hôpitaux de Paris | 31 | 2018-08-28 | 2021-01-19 | |
| Frequency and Type of Genetic Abnormalities Found in Antenatal Corpus Callosum Malformation Corpus Callosum Malformation, Prenatal Disorder | Unknown | University Hospital, Brest | 275 | 2018-06-18 | 2018-09-21 | |
| BECOME CHILDREN OF HOLDERS Corpus Callosum Agenesis Screened IN PERIOD Antenatal Corpus Callosum Agenesis | Unknown | University Hospital, Strasbourg, France | 60 | 2016-07-01 | 2017-05-22 | |
| Infants With Agenesis of the Corpus Callosum Psychometric scales for infants at 3 years of age - Agenesis of the Corpus Callosum | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 72 | 2015-09-26 | 2026-03-31 |
| Impact of Interictal Electroencephalographic Abnormalities on the Stability of Attention in the Epilepsies abnormal EEGs - Epilepsy | Not applicable | Completed | University Hospital, Grenoble | 162 | 2015-05-01 | 2023-10-18 |
| Corpus Callosum Agenesis and Intellectual Disability Genetic - Intellectual Deficiency, Cerebral Abnormality | Completed | Assistance Publique - Hôpitaux de Paris | 360 | 2012-01-01 | 2014-06-19 | |
| The Natural History of Mucolipidosis Type IV Mucolipidosis Type IV | Terminated | Baylor Research Institute | 7 | 2009-02-19 | 2026-01-26 | |
| Biological Clock Dysfunction in Optic Nerve Hypoplasia Melatonin, Placebo Comparator - Biological Clock Dysfunction, Optic Nerve Hypoplasia | Early Phase 1 | Completed | Yale University | 100 | 2008-10-01 | 2020-09-25 |
| A Study of the Genetic Analysis of Brain Disorders Holoprosencephaly | Completed | National Human Genome Research Institute (NHGRI) | 5735 | 2008-06-01 | 2021-12-14 | |
| Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia Nutropin AQ - Growth Hormone Deficiency, Septo-Optic Dysplasia | Phase 4 | Completed | Children's Hospital Los Angeles | 20 | 2004-12-01 | 2015-04-01 |
| Clinical and Genetic Studies on Holoprosencephaly Holoprosencephaly, HPE | Completed | National Human Genome Research Institute (NHGRI) | 256 | 2004-01-23 | 2020-04-20 | |
| Brain Development Research Program Brain Disorders, Aicardi Syndrome | Recruiting | University of California, San Francisco | 2000 | 2003-08-01 | 2026-08-17 | |
| Study of Selected X-Linked Disorders: Aicardi Syndrome Syndrome cause identification - Aicardi Syndrome, Brain Disorders | Recruiting | Baylor College of Medicine | 500 | 2002-10-01 | 2026-05-05 | |
| Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Holoprosencephaly | Completed | National Human Genome Research Institute (NHGRI) | 30 | 2000-03-01 | 2008-03-04 |
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Holoprosencephaly (5) · Septo-Optic Dysplasia (5) · Aicardi Syndrome (3) · Brain Diseases (3) · Congenital Abnormalities (3) · Optic Nerve Hypoplasia (3) · Epilepsy (2) · Intellectual Disability (2) · Accidental Injuries (1) · Autistic Disorder (1) · Blindness (1) · Corneal Opacity (1) · Demyelinating Diseases (1) · Developmental Disabilities (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (21) · Nervous System Diseases (21) · Nervous System Malformations (21) · Congenital Abnormalities (18) · Genetic Diseases, Inborn (11) · Pathological Conditions, Anatomical (10) · Pathological Conditions, Signs and Symptoms (10) · Eye Diseases (9) · Musculoskeletal Diseases (7) · Central Nervous System Diseases (6) · Eye Diseases, Hereditary (6) · Abnormalities, Multiple (5) · Chromosome Disorders (5) · Congenital Cranial Dysinnervation Disorders (5)
Actigraphy (1) · Aging (1) · Blood Specimen Collection (1) · Exome Sequencing (1) · Growth Hormone (1) · Melatonin (1) · setmelanotide (1)
Assistance Publique - Hôpitaux de Paris (4) · National Human Genome Research Institute (NHGRI) (4) · Baylor College of Medicine (1) · Baylor Research Institute (1) · Children's Hospital Los Angeles (1) · Gaziosmanpasa Research and Education Hospital (1) · IRCCS National Neurological Institute "C. Mondino" Foundation (1) · Rennes University Hospital (1) · Rhythm Pharmaceuticals, Inc. (1) · University Hospital, Brest (1) · University Hospital, Grenoble (1) · University Hospital, Strasbourg, France (1) · University of California, San Francisco (1) · Wake Forest University Health Sciences (1) · Yale University (1)
United States (11) · France (8) · Italy (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Benjamin D Solomon, M.D. (1) · Casandra Fink (1) · David Meeker, MD (1) · Elliott H Sherr, MD, PhD (1) · James Barkovich, MD (1) · Jean-Marie Jouannic, MD, PhD (1) · Mark Borchert, MD (1) · Mitchell Geffner, MD (1) · Paul S Kruszka, M.D. (1)
PMID 10739772, PMID 14738943, PMID 16158440, PMID 16275846, PMID 17056927, PMID 17375041, PMID 17546030, PMID 17621479, PMID 17632789, PMID 17668379, PMID 18925666, PMID 19001538, PMID 19116729, PMID 19246528, PMID 19760649, PMID 20206699, PMID 20610117, PMID 20683985, PMID 22681940, PMID 28361097, PMID 31883529, PMID 39819934
U54NS065768 (1)