10 completed, 3 recruiting, 1 terminated, 1 unknown. 5 Not applicable, 4 Phase 4, 2 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 3, Recruiting 1, Unknown 1 |
| Phase 4 | 4 | Completed 2, Recruiting 1, Terminated 1 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow Complicated Appendicitis: new trials by email Literature Review of Complicated Appendicitis trials Research Report on Complicated Appendicitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Lactulose for Gastrointestinal Recovery After Complex Appendectomy Lactulose oral solution, Placebo - Ileus Postoperative, Gastrointestinal Function | Not applicable | Recruiting | Nanchong Central Hospital | 150 | 2026-06-21 | 2026-06-25 |
| Differences In Microbiota Profiles Of Pediatric Appendicitis Cases Appendectomy - Appendicitis Acute, Disbiosis | Not applicable | Completed | Istanbul University | 50 | 2025-08-18 | 2026-10-06 |
| Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis Laparoscopic antibiotic peritoneal lavage with gentamicin / clindamycin - Complicated Appendicitis, Intra-Abdominal Abscess | Phase 3 | Recruiting | Spaarne Gasthuis | 752 | 2025-02-24 | 2026-10-09 |
| New Diagnostic Markers In Dignosis Of Complicated Appendix Bilirubin level sodium level c reactive protein level - Complicated Appendicitis | Not applicable | Unknown | Sohag University | 50 | 2023-10-01 | 2023-10-26 |
| Antibiotic Instillation in Appendicitis Ceftriaxone, Intra-peritoneal Fluid Aspiration - Complicated Appendicitis, Acute Appendicitis | Phase 2 | Completed | Johns Hopkins All Children's Hospital | 190 | 2023-01-05 | 2025-03-13 |
| ERAS for Pediatric Acute Appendicitis ERAS - Pediatric Disorder, Complicated Appendicitis | Not applicable | Completed | Feng Jiexiong | 893 | 2022-01-10 | 2023-12-08 |
| Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics Oral amoxicillin-clavulanic acid (40mg/kg in 3 times/day; maximum dose 3g/day), Inpatient postpoperative intravenous antibiotic treatment according to the established protocol in each center - Laparoscopic Appendectomy, Complicated Appendicitis | Phase 4 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 772 | 2021-04-22 | 2026-09-08 |
| Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis. Antibiotic - Complicated Appendicitis | Not applicable | Completed | Zealand University Hospital | 3193 | 2021-04-01 | 2024-10-01 |
| Causes of Complicated Appendicitis at Referral Hospital Complicated Appendicitis | Completed | Haramaya Unversity | 402 | 2021-02-01 | 2021-08-13 | |
| Antibiotic Duration in Post-appendectomy Abscess ampicillin/clavulanate - Complicated Appendicitis, Perforated Appendicitis | Phase 4 | Terminated | Phoenix Children's Hospital | 7 | 2019-05-01 | 2024-03-08 |
| Complicated Appendicitis During the COVID-19 Pandemic in Jordan Observational Study - COVID-19, Complicated Appendicitis | Completed | Jordan University Hospital | 257 | 2019-03-02 | 2022-05-16 | |
| Optimal Care of Complicated Appendicitis Early Appendectomy, Interval Appendectomy, Antibiotics - Appendicitis, Perforated Appendicitis | Phase 4 | Completed | University of Michigan | 40 | 2017-06-29 | 2023-11-28 |
| Complicated Appendicitis in COVID-19 Era impact of COVID-19 on Health-Seeking Behaviors - Covid19, Complicated Appendicitis | Completed | National Taiwan University Hospital | 465 | 2017-01-01 | 2021-08-19 | |
| Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Eravacycline, Meropenem, Placebo - Complicated Intra-abdominal Infections, Complicated Appendicitis | Phase 3 | Completed | Tetraphase Pharmaceuticals, Inc | 500 | 2016-10-13 | 2022-01-06 |
| Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole - Complicated Appendicitis | Phase 4 | Completed | HaEmek Medical Center, Israel | 43 | 2008-07-01 | 2012-09-05 |
Appendicitis (5) · COVID-19 (2) · Abdomen, Acute (1) · Abdominal Abscess (1) · Dysbiosis (1) · Emergencies (1) · Health Behavior (1)
Infections (7) · Cecal Diseases (5) · Digestive System Diseases (5) · Gastroenteritis (5) · Gastrointestinal Diseases (5) · Intestinal Diseases (5) · Intraabdominal Infections (5) · Pathological Conditions, Signs and Symptoms (3) · Coronaviridae Infections (2) · Coronavirus Infections (2) · Lung Diseases (2) · Nidovirales Infections (2) · Pathologic Processes (2) · Pneumonia (2) · Pneumonia, Viral (2)
Amoxicillin-Potassium Clavulanate Combination (3) · Metronidazole (3) · Ampicillin (2) · Anti-Bacterial Agents (2) · Ceftriaxone (2) · Gentamicins (2) · Piperacillin, Tazobactam Drug Combination (2) · Appendectomy (1) · Ciprofloxacin (1) · Clavulanic Acid (1) · Clindamycin (1) · Lactulose (1) · Meropenem (1) · Observation (1) · Piperacillin (1)
Feng Jiexiong (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · HaEmek Medical Center, Israel (1) · Haramaya Unversity (1) · Istanbul University (1) · Johns Hopkins All Children's Hospital (1) · Jordan University Hospital (1) · Nanchong Central Hospital (1) · National Taiwan University Hospital (1) · Phoenix Children's Hospital (1) · Sohag University (1) · Spaarne Gasthuis (1) · Tetraphase Pharmaceuticals, Inc (1) · University of Michigan (1) · Zealand University Hospital (1)
United States (4) · China (2) · Bulgaria (1) · Czechia (1) · Denmark (1) · Egypt (1) · Estonia (1) · Ethiopia (1) · Georgia (1) · Hungary (1) · Israel (1) · Jordan (1) · Latvia (1) · Lithuania (1) · Netherlands (1)
Badhaasaa Bayissa, MD (1) · Craig Egan, MD (1) · Jiexiong Feng, MD (1) · Maria Jose Martinez-Zapata, MD, PhD (1) · Marzouq Amarin, MD, MSc (1) · Nicole M. Chandler, MD (1) · Steven W. Bruch, M.D. (1)
PMID 30561562, PMID 31570004, PMID 39379540
2025 (1)