12 completed, 4 terminated, 1 not yet recruiting, 1 unknown. 18 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 12, Terminated 4, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 4 | Completed 2, Terminated 2 |
Follow Clostridium Difficile Infection: new trials by email Literature Review of Clostridium Difficile Infection trials Research Report on Clostridium Difficile Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Safety Trial to Evaluate an Orally Ingested Yeast Modified to Express a Tetra-specific Anti-toxin for Clostridioides Difficile FZ002, Placebo for FZ002 - Clostridium Difficile Infection | Phase 1 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 56 | 2026-10-29 | 2026-10-30 |
| Fecal Microbiota Transplant for Primary CDI Fecal microbiota transplant G3 capsules, Oral Vancomycin alone - Clostridium Difficile Infection | Phase 1 / Phase 2 | Terminated | Boston Medical Center | 5 | 2019-08-23 | 2021-12-15 |
| Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile Vancomycin Oral Capsule, Placebo Oral Capsule - Clostridium Difficile Infection | Phase 1 | Completed | Medical College of Wisconsin | 7 | 2019-07-17 | 2021-10-20 |
| MET-2 Clinical Study for Recurrent Clostridium Difficile Infection (CDI) MET-2, Vancomycin - Clostridium Difficile Infection | Phase 1 | Completed | NuBiyota | 19 | 2017-10-27 | 2020-08-11 |
| Treatment for Clostridium-difficile Infection With IMM529 IMM-529, Placebo - Clostridium Difficile Infection, Clostridium Difficile Infection Recurrence | Phase 1 / Phase 2 | Terminated | Immuron Ltd. | 9 | 2017-09-01 | 2019-12-26 |
| The ICON Study: Outcomes After FMT for Patients With IBD and CDI Fecal Microbiota Transplantation - Inflammatory Bowel Diseases, Clostridium Difficile Infection | Phase 1 / Phase 2 | Completed | Brigham and Women's Hospital | 50 | 2017-08-01 | 2021-02-10 |
| Oral Vaccination Against Clostridium Difficile Infection CDVAX - Clostridium Difficile Infection | Phase 1 | Terminated | Simon M. Cutting | 3 | 2017-01-01 | 2017-07-25 |
| Treatment of Recurrent Clostridium Difficile Infection With RBX7455 RBX7455 - Clostridium Difficile Infection | Phase 1 | Completed | Mayo Clinic | 30 | 2016-11-01 | 2020-12-08 |
| SER-262 Versus Placebo in Adults With Primary Clostridium Difficile Infection to Prevent Recurrence SER-262, Placebo - Clostridium Difficile Infection | Phase 1 | Completed | Seres Therapeutics, Inc. | 96 | 2016-08-01 | 2023-02-06 |
| Freeze-dried, Capsulized FMT for RCDI Fecal Microbiota Transplantation - Clostridium Difficile Infection | Phase 1 | Unknown | Jinling Hospital, China | 20 | 2015-03-01 | 2016-05-25 |
| Phase I Trial to Determine the Safety and Pharmacokinetics of CRS3123. Placebo, CRS3123 - Clostridium Difficile Infection | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 36 | 2014-06-01 | 2016-06-13 |
| Fecal Microbiota Transplant for Relapsing Clostridium Difficile Infection in Adults and Children Using a Frozen Encapsulated Inoculum Fecal Microbiota Transplant - Clostridium Difficile Infection | Phase 1 | Completed | Massachusetts General Hospital | 20 | 2013-08-01 | 2016-07-19 |
| Study of a Candidate Clostridium Difficile Toxoid Vaccine in Healthy Adult Subjects Aged 40 to 75 Years in Japan Clostridium difficile Toxoid Vaccine, 0.9% normal saline - Clostridium Difficile Infection | Phase 1 / Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 102 | 2013-07-01 | 2018-07-18 |
| The Impact of Proton Pump Inhibitors on the Fecal Microbiome omeprazole - Healthy, Clostridium Difficile Infection | Phase 1 | Completed | Mayo Clinic | 15 | 2013-03-01 | 2014-08-20 |
| Fecal Microbiota Transplant (FMT) for Relapsing C. Difficile Infection in Adults and Children Using a Frozen Inoculum Fecal Microbiota Transplant (FMT) - Clostridium Difficile Infection | Phase 1 | Completed | Massachusetts General Hospital | 20 | 2012-11-01 | 2014-06-20 |
| Study to Investigate the Pharmacokinetics and Safety of Cadazolid in Patients With Clostridium Difficile Infection Cadazolid - Clostridium Difficile Infection | Phase 1 | Completed | Actelion | 6 | 2012-08-01 | 2014-02-03 |
| An Open-label Study Assessing Safety, Immunogenicity and Dose Response of IC84 IC84 - Clostridium Difficile Infection | Phase 1 | Completed | Valneva Austria GmbH | 82 | 2010-12-01 | 2014-09-25 |
| Phase I Randomized, Placebo-Controlled, Double-Blind, Dose Ranging Study, Safety, Tolerability and Immunogenicity Vaccine diluent buffer, Clostridium difficile toxoid vaccine (50 μg), Clostridium difficile toxoid vaccine (100 μg) - Clostridium Difficile Infection, Clostridium Difficile Diarrhea | Phase 1 | Terminated | Sanofi | 36 | 2006-03-01 | 2012-05-21 |
Clostridium Infections (18) · Diarrhea (2) · Dysbiosis (1) · Inflammatory Bowel Diseases (1) · Reinfection (1)
Bacterial Infections (18) · Bacterial Infections and Mycoses (18) · Gram-Positive Bacterial Infections (18) · Infections (18) · Pathological Conditions, Signs and Symptoms (4) · Pathologic Processes (2) · Signs and Symptoms (2) · Signs and Symptoms, Digestive (2) · Digestive System Diseases (1) · Disease Attributes (1) · Gastroenteritis (1) · Gastrointestinal Diseases (1) · Intestinal Diseases (1) · Recurrence (1)
Fecal Microbiota Transplantation (4) · Vancomycin (3) · Omeprazole (1) · REP 3123 (1) · Saline Solution (1) · cadazolid (1)
Massachusetts General Hospital (2) · Mayo Clinic (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Actelion (1) · Boston Medical Center (1) · Brigham and Women's Hospital (1) · Immuron Ltd. (1) · Jinling Hospital, China (1) · Medical College of Wisconsin (1) · NuBiyota (1) · Sanofi (1) · Sanofi Pasteur, a Sanofi Company (1) · Seres Therapeutics, Inc. (1) · Simon M. Cutting (1) · Valneva Austria GmbH (1)
United States (10) · Austria (1) · Canada (1) · China (1) · Croatia (1) · Hungary (1) · Israel (1) · Japan (1)
Alison Mackie, MSc (1) · Andrea Ayad, Dr. (1) · Dennis N Morrison, D.O. (1) · Dina Kao, MD (1) · Elizabeth Hohmann, MD (1) · Elizabeth L Hohmann, MD (1) · Jerry Kanellos (1) · Jessica R Allegretti, MD, MPH (1) · John Di Baise, MD (1) · Michele Trucksis, PhD, MD (1) · Neta Tobis (1) · Ning Li, MD (1) · Sahil Khanna (1) · Silvia Munoz-Price, M.D., Ph.D. (1)
PMID 24762631, PMID 26419191, PMID 27079932, PMID 29116880, PMID 31685472, PMID 32966574, PMID 33631102