3 unknown, 2 completed. 5 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Unknown 3, Completed 2 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
Follow Charcot-Marie-Tooth Disease: new trials by email Literature Review of Charcot-Marie-Tooth Disease trials Research Report on Charcot-Marie-Tooth Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients (RS)-baclofen, naltrexone hydrochloride and D-sorbitol, Placebo - Charcot-Marie-Tooth Disease | Phase 3 | Unknown | Pharnext S.C.A. | 350 | 2021-03-30 | 2024-04-03 |
| Assessing Long Term Safety and Tolerability of PXT3003 in Patients With Charcot-Marie-Tooth Disease Type 1A PXT3003 - Charcot-Marie-Tooth Disease, Type IA | Phase 3 | Unknown | Pharnext S.C.A. | 187 | 2017-03-07 | 2024-02-20 |
| Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients (PLEO-CMT) PXT3003 dose 1, PXT3003 dose 2, placebo - Charcot-Marie-Tooth Disease Type 1A | Phase 3 | Completed | Pharnext S.C.A. | 323 | 2015-12-01 | 2020-02-27 |
| Treadmill, Stretching and Proprioceptive Exercise (TreSPE) Rehabilitation Program for Charcot-Marie-Tooth Neuropathy Type 1A (CMT1A) TreSPE, SPE - Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth Disease Type 1A | Phase 2 / Phase 3 | Unknown | University of Genova | 92 | 2011-02-01 | 2011-02-04 |
| High Dose Ascorbic Acid Treatment of CMT1A Ascorbic acid (Vitamin C), placebo - Charcot-Marie-Tooth Disease, Type Ia | Phase 2 / Phase 3 | Completed | Wayne State University | 110 | 2007-04-01 | 2013-03-06 |
Peripheral Nervous System Diseases (2)
Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Genetic Diseases, Inborn (5) · Hereditary Sensory and Motor Neuropathy (5) · Heredodegenerative Disorders, Nervous System (5) · Nervous System Diseases (5) · Nervous System Malformations (5) · Neurodegenerative Diseases (5) · Neuromuscular Diseases (5) · Polyneuropathies (5) · Peripheral Nervous System Diseases (3)
Ascorbic Acid (1) · Naltrexone (1) · Sorbitol (1)
Pharnext S.C.A. (3) · University of Genova (1) · Wayne State University (1)
United States (4) · Belgium (3) · Canada (3) · France (3) · Spain (3) · Germany (2) · Italy (2) · Netherlands (2) · United Kingdom (2) · Denmark (1) · Israel (1)
Mark Roberts, MD (2) · Shahram Attarian, MD (2) · Teresa Sevilla, MD (2) · Angelo E Schenone, MD (1) · Florian Thomas, MD (1) · Florian Thomas, MD PhD (1) · Jack Puymirat, MD (1) · Marianne De Visser, MD (1) · Marianne de Visser, MD (1) · Mario Saporta, MD (1) · Peter Young, MD (1) · Philip Van Damme, MD (1) · Richard A Lewis, MD (1) · Sharam Attarian, MD (1)
PMID 23797954, PMID 25491744, PMID 25519680, PMID 26070802, PMID 27387831, PMID 30650121
2015 (2)