16 completed, 5 unknown, 1 active not recruiting, 1 terminated. 12 Not applicable, 5 Phase 2, 4 Phase 3, 1 Early Phase 1, 1 Phase 1.
Follow Biotin: new trials by email Literature Review of Biotin trials Research Report on Biotin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Evaluating the Effect of Nutra Harmony "Biotin, Collagen and Keratin Beauty Complex" Dietary Supplement on Hair Thickness and Hair Strength in Adults With Self-Perceived Thinning Hair Complex with Biotin 5,000 mcg, Collagen, Keratin and Hyaluronic Acid., Complex with Biotin 10,000 mcg, Collagen, Keratin and Hyaluronic Acid. - Hair Thinning | Not applicable | Active not recruiting | Nutra Harmony LLC | 40 | 2026-01-15 | 2026-04-14 |
| Biotin-Acridine Red Cell Exchange Kinetics Pathogen reduced red blood cells - Sickle Cell Disease | Phase 2 | Withdrawn | Cerus Corporation | 2025-10-15 | 2026-09-22 | |
| Study Evaluating the Effects of Dietary Supplement on Hair Thickness and Hair Strength in Individuals With Self-Perceived Thinning Hair Complex with Biotin, Collagen, Keratin, Hyaluronic Acid., Placebo product - Hair Thinning | Not applicable | Completed | Nutra Harmony LLC | 80 | 2024-02-19 | 2026-02-03 |
| Effectiveness of a Novel Dietary Ingredient on Hair Growth and Skin's Appearance Biotin and silicon, Placebo - Hair Thinning, Facial Skin Texture | Not applicable | Unknown | Nutrition 21, Inc. | 101 | 2023-08-11 | 2023-08-25 |
| Can Biotin Supplementation be Used to Mask hCG Abuse? Choriogonadotropin Alpha, biotin, Microcellulose filler - Healthy | Early Phase 1 | Completed | Sports Medicine Research and Testing Laboratory | 10 | 2022-10-27 | 2023-02-03 |
| The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma Placebo, L-Carnitine 500Mg Oral Tablet, Biotin Capsules - Moderate Persistent Asthma | Phase 3 | Unknown | Tanta University | 66 | 2022-08-08 | 2022-11-30 |
| Evaluation of the Efficacy of a New Supplement for Hair and Nails - in Vitro, Clinical, Subjective and Instrumental Study A power supplement with biotin - Hair Loss, Nails, Ingrown | Not applicable | Completed | Farmoquimica S.A. | 40 | 2022-03-07 | 2023-07-14 |
| Effects of an Acute Dose of Caffeine on the Performance of CrossFit Athletes Caffeine administration according to body mass (moderate intake- 7 mg/kg), Placebo (Biotin Capsules) - Healthy, Young Adults, Athletic Performance | Not applicable | Completed | Democritus University of Thrace | 12 | 2022-01-22 | 2025-03-26 |
| TQT2 Study to Evaluate the Effect of MD1003 on Cardiac Repolarization in Healthy Adult Subjects MD1003, Moxifloxacin 400mg, Placebo for MD1003 - Healthy Volunteers | Phase 1 | Unknown | MedDay Pharmaceuticals SA | 64 | 2019-11-11 | 2020-02-20 |
| Effect of Biotin on Routine Laboratory Values Biotin - Biotin Ingestion, Interference With Routine Analyical Tests | Phase 4 | Completed | Dr. med. Mahir Karakas | 101 | 2019-01-11 | 2020-05-22 |
| Biotin Sample Collection Study Biotin - Healthy Volunteers, Biotin Excretion | Not applicable | Completed | SPD Development Company Limited | 12 | 2018-11-07 | 2019-02-08 |
| Evaluation of the Incidence of Relapses in Patients With Biotin-treated Progressive Multiple Sclerosis biotin, propensity score - Progressive Multiple Sclerosis | Unknown | University Hospital, Clermont-Ferrand | 3000 | 2018-05-30 | 2018-06-11 | |
| Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral Sclerosis Biotin, Placebo Oral Tablet - Amyotrophic Lateral Sclerosis | Phase 2 | Completed | American University of Beirut Medical Center | 12 | 2018-01-29 | 2021-09-01 |
| PROVIT The Influence of Probiotics on Body and Mind in Individuals With Psychiatric Disorders Probiotics and vitamin B7, Placebo and vitamin B7 - Mood Disorders, Depression | Not applicable | Unknown | Medical University of Graz | 80 | 2017-06-21 | 2018-09-18 |
| SERENDEM : MD1003 in Patients Suffering From Demyelinating Neuropathies, an Open Label Pilot Study MD1003 - Chronic Inflammatory Demyelinating Polyneuropathy, Peripheral Neuropathy | Phase 2 | Completed | MedDay Pharmaceuticals SA | 15 | 2016-12-05 | 2020-11-02 |
| Effect of MD1003 in Progressive Multiple Sclerosis (SPI2) MD1003 100mg capsule, PLACEBO - Multiple Sclerosis | Phase 3 | Terminated | MedDay Pharmaceuticals SA | 642 | 2016-12-01 | 2020-11-23 |
| Effect of MD1003 in Amyotrophic Lateral Sclerosis MD1003, Placebo oral capsule - ALS, Amyotrophic Lateral Sclerosis | Phase 2 | Completed | MedDay Pharmaceuticals SA | 30 | 2016-06-29 | 2019-06-04 |
| Interference of Biotin Supplementation in Biotin-streptavidin Platforms for Hormone Testing biotin - Thoracic Diseases, Parathyroid Diseases | Not applicable | Completed | University of Minnesota | 12 | 2016-04-01 | 2019-04-19 |
| MD1003-AMN MD1003 in Adrenomyeloneuropathy MD1003 100 mg capsule, Placebo - Adrenomyeloneuropathy, Adrenoleukodystrophy | Phase 2 / Phase 3 | Completed | MedDay Pharmaceuticals SA | 67 | 2014-10-01 | 2017-10-09 |
| Biotin Status in Pregnancy biotin - Biotin Deficiency | Not applicable | Completed | University of Arkansas | 124 | 2009-08-01 | 2015-03-02 |
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Alopecia (4) · Amyotrophic Lateral Sclerosis (2) · Diabetes Mellitus, Type 2 (2) · Multiple Sclerosis (2) · Multiple Sclerosis, Chronic Progressive (2) · Abortion, Habitual (1) · Adrenoleukodystrophy (1) · Anemia, Sickle Cell (1) · Biotin deficiency (1) · Charcot-Marie-Tooth Disease (1) · Depression (1) · Hyperglycemia (1) · Kidney Failure, Chronic (1) · Mood Disorders (1) · Motor Neuron Disease (1)
MedDay Pharmaceuticals SA (5) · Nutrition 21, Inc. (3) · Nutra Harmony LLC (2) · American University of Beirut Medical Center (1) · Cerus Corporation (1) · Democritus University of Thrace (1) · Dr. med. Mahir Karakas (1) · Farmoquimica S.A. (1) · Heidi Moretti, MS, RD (1) · Medical University of Graz (1) · SPD Development Company Limited (1) · Sports Medicine Research and Testing Laboratory (1) · Tanta University (1) · University Hospital, Clermont-Ferrand (1) · University of Arkansas (1)
United States (5) · France (4) · Germany (4) · United Kingdom (3) · Austria (2) · Spain (2) · Ukraine (2) · Australia (1) · Belgium (1) · Brazil (1) · Canada (1) · Czechia (1) · Egypt (1) · Greece (1) · Hungary (1)
Frederic Sedel, MD (2) · Achraf Makki, MD (1) · Andre Crouch, MD (1) · Angela Radulescu, MD (1) · Bruce Cree, MD, PHD (1) · Cesar Albarracin, MD (1) · Donald M Mock, MD,PhD (1) · Ekkehard Schleussner, Prof. Dr. (1) · Eva Reininghaus, PD, MD (1) · Frederic Sedel, MD, PHD (1) · Jeffery Geohas, MD (1) · John Lakatua, MD (1)
PMID 11750036, PMID 17182796, PMID 17684468, PMID 19192301, PMID 19268425, PMID 22714021, PMID 23039386, PMID 23217177, PMID 25787192, PMID 25938990, PMID 27418639, PMID 27589059, PMID 28973622, PMID 32140672, PMID 33222767, PMID 33779986, PMID 37253044, PMID 37899433, PMID 42712237
R01DK079892 (1)