15 completed, 3 recruiting, 2 terminated. 5 Not applicable, 4 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 3, Recruiting 2 |
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
Follow Central Nervous System: new trials by email Literature Review of Central Nervous System trials Research Report on Central Nervous System
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PSYLIVER-PILOTE: Involvement of the Autonomic Nervous System in Hepatocellular Carcinoma (HCC) Measurements of autonomic nervous system (ANS) activity at rest and during sensory stimulation., Self-administered questionnaires to assess psycho-behavioral traits, Analysis of nocturnal cardiac activity (at home): electrocardiographic (ECG) recording of heart activity during one night. - Hepato Cellular Carcinoma, Cirrhosis | Not applicable | Recruiting | Hospices Civils de Lyon | 100 | 2026-04-17 | 2026-04-29 |
| Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study One time CSF and blood sample - Solid Tumor Malignancies, Brain Metastasases | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 60 | 2025-12-12 | 2026-07-31 |
| A Clinical Study to Evaluate the Drug Interaction Between YZJ-1139 Tablets and Escitalopram Oxalate Tablets YZJ-1139 tablets, Escitalopram oxalate tablets, YZJ-1139 simulated tablets - Insomnia, Central Nervous System | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 24 | 2024-08-31 | 2026-06-30 |
| Sensorimotor Cortex Excitability in Shoulder Impingement Syndrome No intervention - Shoulder Impingement Syndrome, Chronic Pain | Completed | National Yang Ming Chiao Tung University | 40 | 2022-08-28 | 2024-11-15 | |
| A Home-Based Approach Study to Evaluate the Efficacy and Safety of Alectinib in Locally-Advanced or Metastatic ALK-Positive Solid Tumors Alectinib - Neoplasms, Colorectal Neoplasms | Phase 2 | Terminated | Hoffmann-La Roche | 1 | 2021-05-24 | 2023-08-07 |
| Rapid Declarative Neocortical Declarative Learning in Aging and Memory Diseases (ANéRAVIMM) Neuropsychological tests - Neurological Diseases, Central Nervous System | Not applicable | Completed | Rennes University Hospital | 97 | 2021-04-28 | 2026-06-17 |
| The Effects of Exercise Training on Corticospinal System in Overhead Athletes With Shoulder Impingement Syndrome Scapula control exercise, scapular strengthening exercise, No intervention - Shoulder Impingement Syndrome, Transcranial Magnetic Stimulation | Not applicable | Completed | National Yang Ming Chiao Tung University | 65 | 2019-10-22 | 2021-05-24 |
| Xanamem™ in Healthy Elderly Subjects Xanamem, Matching Placebo - Safety, Peripheral Neuropathy | Phase 1 | Completed | Actinogen Medical | 42 | 2019-01-21 | 2025-01-22 |
| Brain Networks and Mobility Function: B-NET Central Nervous System, White Matter Disease | Completed | Wake Forest University Health Sciences | 192 | 2018-07-20 | 2023-08-18 | |
| Contrast-enhanced 3D T1-weighted Gradient-echo Versus Spin-echo 3 Tesla MR Sequences in the Detection of Active Multiple Sclerosis Lesions Additional MRI sequences - Magnetic Resonance Imaging, Central Nervous System | Not applicable | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 180 | 2017-08-02 | 2026-01-06 |
| Effects of Switching From ATRIPLA™ (Efavirenz, Tenofovir, Emtricitabine) to MK-1439A (Doravirine, Tenofovir, Lamivudine) in Virologically-Suppressed Participants (MK-1439A-028) Doravirine, Tenofovir, Lamivudine - Blinded, Doravirine, Tenofovir, Lamivudine - Open-Label, ATRIPLA^TM - HIV-1, Central Nervous System | Phase 2 | Completed | Merck Sharp & Dohme LLC | 86 | 2016-03-04 | 2025-02-07 |
| Computer-based Neurocognitive Assessment in Children With Central Nervous System Tumors Receiving Proton Beam Radiation Therapy NIH Toolbox Cognitive Battery - Central Nervous System | Recruiting | Washington University School of Medicine | 80 | 2015-10-13 | 2026-04-30 | |
| Vinblastine and Temsirolimus in Pediatrics With Recurrent or Refractory Lymphoma or Solid Tumours Including CNS Tumours Vinblastine, Temsirolimus - Recurrent Lymphoma, Refractory Lymphoma | Phase 1 | Completed | Canadian Cancer Trials Group | 7 | 2015-06-24 | 2023-08-04 |
| Studying Motor Neuron Tests Healthy Subjects, Magnetic Resonance Imaging | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 47 | 2012-02-01 | 2021-03-12 | |
| Pharmacokinetics, Efficacy, and Safety of Perampanel Oral Suspension on Seizure Frequency in Pediatric Subjects Maintained on One to Three Stable Antiepileptic Drugs perampanel - Central Nervous System | Phase 2 | Completed | Eisai Inc. | 63 | 2012-01-01 | 2016-07-12 |
| Touch and Attention MRI Study Central Nervous System | Completed | Wake Forest University | 10 | 2011-08-01 | 2017-08-10 | |
| A Study in Healthy Subjects to Determine the Effects When Alcohol is Administered With Perampanel alcohol + placebo, alcohol + perampanel, perampanel + alcohol - Central Nervous System | Phase 1 | Completed | Eisai Limited | 59 | 2010-05-01 | 2012-02-13 |
| Circulating microRNAs as Disease Markers in Pediatric Cancers Leukemia, Lymphoma | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 20 | 2010-03-01 | 2025-01-24 | |
| Recording and Modulation of Neuronal Mechanisms During Operant Conditioning: a MEG Study Central Nervous System | Terminated | National Institute of Neurological Disorders and Stroke (NINDS) | 20 | 2009-10-22 | 2019-12-17 | |
| Investigating Endothelial Precursor Cells (EPCs) Central Nervous System | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 84 | 2003-08-01 | 2008-03-04 |
Brain Neoplasms (2) · Lymphoma (2) · Shoulder Impingement Syndrome (2) · Breast Neoplasms (1) · Bronchial Neoplasms (1) · Carcinoma, Bronchogenic (1) · Carcinoma, Renal Cell (1) · Cholangiocarcinoma (1) · Chronic Pain (1) · Colonic Diseases (1) · Colorectal Neoplasms (1) · Demyelinating Diseases (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Fibrosis (1)
Nervous System Diseases (7) · Immune System Diseases (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Central Nervous System Neoplasms (3) · Hemic and Lymphatic Diseases (3) · Immunoproliferative Disorders (3) · Lymphatic Diseases (3) · Lymphoproliferative Disorders (3) · Nervous System Neoplasms (3) · Joint Diseases (2) · Musculoskeletal Diseases (2) · Neoplasms by Site (2)
perampanel (2) · Blood Specimen Collection (1) · Escitalopram (1) · Ethanol (1) · Lamivudine (1) · Neuropsychological Tests (1) · Tenofovir (1) · UE2343 (1) · Vinblastine (1) · alectinib (1) · doravirine (1) · epicatechin gallate (1) · temsirolimus (1)
National Institute of Neurological Disorders and Stroke (NINDS) (3) · National Yang Ming Chiao Tung University (2) · Actinogen Medical (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Canadian Cancer Trials Group (1) · Eisai Inc. (1) · Eisai Limited (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Hoffmann-La Roche (1) · Hospices Civils de Lyon (1) · Merck Sharp & Dohme LLC (1) · Rennes University Hospital (1) · Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (1) · Sunnybrook Health Sciences Centre (1) · Wake Forest University (1)
United States (9) · France (3) · Canada (2) · Taiwan (2) · Australia (1) · China (1) · United Kingdom (1)
Yin-Liang Lin, PhD (2) · Bill Ketelbey, MD (1) · Daryl Bendel (1) · Kathi Kemper, MD, MPH (1) · Mark Hallett, M.D. (1) · Mary Kay Floeter, M.D. (1) · Michelle Gee (1) · Rebecca Deyell (1) · Rishi Lulla, MD (1) · Stephanie Perkins, M.D. (1) · Stephen Kritchevsky, PhD (1) · Sylvain Baruchel (1)
PMID 30299161, PMID 30393943, PMID 30739576, PMID 33587439, PMID 36729811
2015 (1), R01AG052419 (1)