81 completed, 13 unknown, 8 recruiting, 6 not yet recruiting. 73 Not applicable, 12 Phase 3, 10 Phase 2, 2 Phase 1, 2 Phase 4.
Follow Severe Acute Malnutrition: new trials by email Literature Review of Severe Acute Malnutrition trials Research Report on Severe Acute Malnutrition
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Relapse to Acute Malnutrition Prevention (RAMP) Trial Azithromycin, Placebo (Azithromycin), Small-quantity Lipid-based Nutrient Supplements - Acute Malnutrition in Childhood, Acute Malnutrition, Severe | Not applicable | Not yet recruiting | Action Against Hunger USA | 3750 | 2026-10-01 | 2026-10-13 |
| Safety Trial of F-60 Among Children Hospitalized With SAM F75 milk feeds, F60 milk feeds - Dietary Supplementation, Severe Acute Malnutrition | Not applicable | Enrolling by invitation | International Centre for Diarrhoeal Disease Research, Bangladesh | 320 | 2026-07-01 | 2026-08-07 |
| Regular Growth Monitoring (RGM) of Young Children in Guinea-Bissau Regular Growth Monitoring (RGM) by Community Health Agents - Severe Acute Malnutrition, Moderate Acute Malnutrition (MAM) | Not applicable | Active not recruiting | Trustees of Dartmouth College | 400 | 2026-05-05 | 2026-07-15 |
| Reduced Dosage and/or Visitation Protocol for the Treatment of Acute Malnutrition in Kenya WHO-reduced, WHO-full, Kenya-IMAM - Acute Malnutrition in Childhood, Acute Malnutrition, Severe | Not applicable | Not yet recruiting | International Food Policy Research Institute | 2274 | 2026-03-01 | 2026-02-19 |
| Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya Iron absorption from RUTF on Day 0, Treatment with RUTF for 80 days, Iron absorption from RUTF on Day 20 - Iron Absorption, Iron Deficiencies | Not applicable | Recruiting | ETH Zurich | 68 | 2025-12-23 | 2026-01-02 |
| Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition MFGM-RUTF (milk fat globule membrane ready-to-use therapeutic food), S-RUTF (standard ready-to-use therapeutic food), Amoxicillin - Severe Acute Malnutrition, Cognitive Impairment | Not applicable | Recruiting | Washington University School of Medicine | 1600 | 2025-09-22 | 2026-10-23 |
| The Effect of a Plant-based, Protein-dense Sauce on Essential Amino Acid Concentrations and Gut Fullness in Older Adults ProSauce, low-protein sauce - Malnutrition Elderly, Protein Malnutrition | Not applicable | Recruiting | University of Exeter | 20 | 2025-07-10 | 2025-09-23 |
| Efficacy of Striatin in Malnourished Children Striatin, Placebo - Severe Acute Malnutrition | Phase 3 | Completed | Universitas Sriwijaya | 30 | 2025-05-20 | 2026-04-29 |
| Alternative RUTFs for Treatment of Child Wasting Soy-based RUTF, Soy-maize-sorghum-based RUTF, Standard RUTF - Severe Acute Malnutrition, Moderate Acute Malnutrition | Phase 3 | Completed | International Food Policy Research Institute | 2269 | 2025-03-21 | 2026-05-13 |
| Slow Introduction of Nutrition for Ill Malnourished Children F75 milk feeds, F50 milk feeds, F35 milk feeds - Malnutrition, Severe Acute, Malnutrition, Child | Phase 1 | Active not recruiting | The Hospital for Sick Children | 135 | 2025-02-05 | 2026-04-24 |
| Severe Acute Malnutrition and Child Development Clinical Trial in Mwanza Ready to Use Therapeutic Food (RUTF), Psychosocial stimulation - Severe Acute Malnutrition in Childhood | Phase 3 | Not yet recruiting | National Institute for Medical Research, Tanzania | 800 | 2025-02-03 | 2025-01-17 |
| RECIPE BASED F100 INTERVENTION FOR NUTRITIONAL EFFICACY IN SAM (REFINE-SAM ) WHO F100, WHO RECIPE BASED F100 - Severe Acute Malnutrition | Not applicable | Completed | Children's Hospital and Institute of Child Health, Multan | 114 | 2025-01-01 | 2025-08-24 |
| Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study) WHO-recommended standard therapeutic milk used for stabilization phase in SAM), HO-recommended Rice based therapeutic milk used for stabilization phase in SAM) - Severe Acute Malnutrition, Persistent Diarrhea | Not applicable | Completed | Children's Hospital and Institute of Child Health, Multan | 320 | 2024-12-31 | 2025-08-24 |
| Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute Malnutrition Azithromycin, Amoxicillin, Placebo - Malnutrition, Child, Severe Acute Malnutrition | Phase 4 | Recruiting | University of California, San Francisco | 3000 | 2024-10-23 | 2025-10-15 |
| LIver FRAilty Management IN Cirrhosis (LIFRAMIN) Aminolife Plus by Piemme Pharmatech, Italy - Sarcopenia, Cirrhosis, Liver | Not applicable | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 30 | 2024-08-02 | 2026-09-25 |
| An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM Rifampicin, Azithromycin, Isoniazid - Severe Acute Malnutrition, HIV | Phase 3 | Completed | Queen Mary University of London | 674 | 2024-07-15 | 2026-08-25 |
| Comparison of Clinical Outcomes According to High-protein Provision in Critically Ill Patients After Abdominal Surgery Active protein supplementation, Conventional protein supplementation - Protein Malnutrition | Not applicable | Not yet recruiting | Seoul St. Mary's Hospital | 152 | 2024-07-01 | 2024-06-13 |
| Plant Protein Blend and Milk Protein Supplements in Older Individuals Resistance exercise, Standardized diet, Plant protein supplement - Sarcopenia, Skeletal Muscle Atrophy | Not applicable | Completed | Maastricht University Medical Center | 51 | 2024-06-26 | 2025-12-18 |
| Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in Kenya SWITCH intervention package - Acute Malnutrition, Severe, Malnutrition, Child | Not applicable | Recruiting | International Food Policy Research Institute | 1600 | 2024-06-03 | 2026-07-15 |
| The DECIDE-TB Trial; Validation of Treatment Decision Algorithms for Childhood Tuberculosis The comprehensive TDA based approach - Tuberculosis, Child Health | Not applicable | Recruiting | Chishala Chabala | 30240 | 2024-06-01 | 2026-03-24 |
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Kwashiorkor (45) · Malnutrition (24) · Cachexia (17) · Child Nutrition Disorders (12) · Protein-Energy Malnutrition (11) · Growth Disorders (6) · Sarcopenia (6) · Frailty (4) · Cognitive Dysfunction (3) · Infant Nutrition Disorders (3) · Tuberculosis (3) · Critical Illness (2) · Kidney Failure, Chronic (2) · Lymphoma, Follicular (2)
Nutritional and Metabolic Diseases (117) · Nutrition Disorders (116) · Malnutrition (93) · Pathological Conditions, Signs and Symptoms (40) · Signs and Symptoms (29) · Body Weight (21) · Pathologic Processes (18) · Body Weight Changes (17) · Thinness (17) · Weight Loss (17) · Deficiency Diseases (12) · Protein Deficiency (11) · Infections (8) · Atrophy (7)
Amoxicillin (9) · Azithromycin (4) · S-Adenosylmethionine (3) · Dietary Supplements (2) · Eggs (2) · Nutrition Assessment (2) · Proteins (2) · Resistance Training (2) · AIEOP acute lymphoblastic leukemia protocol (1) · Acetylglucosamine (1) · Albendazole (1) · Algorithms (1) · Amino Acids (1) · Amino Acids, Sulfur (1) · Blood Specimen Collection (1)
International Centre for Diarrhoeal Disease Research, Bangladesh (9) · Washington University School of Medicine (9) · Epicentre (7) · University of California, San Francisco (5) · International Food Policy Research Institute (4) · The Hospital for Sick Children (4) · Action Against Hunger USA (3) · Action Contre la Faim (3) · Alliance for International Medical Action (3) · Queen Mary University of London (3) · University Ghent (3) · University of Oxford (3) · Baylor College of Medicine (2) · Children's Hospital and Institute of Child Health, Multan (2) · Institut National de la Santé Et de la Recherche Médicale, France (2)
Bangladesh (12) · Malawi (10) · Burkina Faso (7) · Kenya (7) · Indonesia (6) · Niger (5) · Pakistan (5) · Zambia (5) · Nigeria (4) · United States (4) · Democratic Republic of the Congo (3) · Ethiopia (3) · India (3) · Jamaica (3) · Netherlands (3)
Mark J Manary, MD (7) · Bintou Sanogo, MSc. Md. (3) · Indi Trehan, MD MPH DTM&H (3) · Jerome Some, Md. PhD (3) · Souheila Abbeddou, MSc. PhD (3) · Stefaan De Henauw, Md. PhD (3) · Catherine Oldenburg, ScD (2) · Francisco M Tercero, MD (2) · James A Berkley, FRCPCH (2) · Kelvin D Higa, MD (2) · Kenneth Maleta, MBBS PhD (2) · Muhammad T Sultan, PhD (2) · Sheila Isanaka, ScD (2) · Yosef B Asefaw, MSc (2) · Abdelrahim A Sadek, MD, PhD (1)
PMID 34726694, PMID 40200326, PMID 10371570, PMID 12189242, PMID 15213282, PMID 1632474, PMID 17194194, PMID 19593244, PMID 19595348, PMID 21615299, PMID 21627690, PMID 22170355, PMID 23363496, PMID 23496872, PMID 23746772, PMID 23746776, PMID 24004889, PMID 24067666, PMID 24196006, PMID 24661049, PMID 25850698, PMID 25902844, PMID 25992287, PMID 26068100, PMID 26323041, PMID 26440279, PMID 26708726, PMID 26840134, PMID 26975590, PMID 27265353, PMID 27673385, PMID 27776521, PMID 27895846, PMID 28052519, PMID 28144779, PMID 28316439, PMID 28404577, PMID 28441944, PMID 28509730, PMID 28588982, PMID 28933421, PMID 28934235, PMID 29178404, PMID 29318195, PMID 29522089, PMID 29527358, PMID 29635501, PMID 29690899, PMID 29690916, PMID 29895309
2017 (1), R01DK056689 (1), R01DK075018 (1), R01HD111532 (1)