85 completed, 16 terminated, 8 unknown, 6 recruiting. 124 Phase 3, 20 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 124 | Completed 85, Terminated 16, Unknown 8, Recruiting 6, Active not recruiting 5, Withdrawn 4 |
| Phase 2 | 20 | Completed 13, Terminated 3, Unknown 2, Withdrawn 2 |
Follow Bronchiolitis: new trials by email Literature Review of Bronchiolitis trials Research Report on Bronchiolitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Efficacy and Safety of Belumosudil Compared With Best Available Therapy in Participants Aged 12 Years or Older With Chronic Graft-versus-host Disease Belumosudil, Best available therapy (BAT) - Chronic Graft Versus Host Disease | Phase 3 | Recruiting | Sanofi | 356 | 2026-10-12 | 2026-11-06 |
| An Efficacy and Safety Study of DFL24498 in the Treatment of AKC DFL24498, Vehicle, dexamethasone sodium phosphate (DSP) ophthalmic solution - Atopic Keratoconjunctivitis | Phase 3 | Recruiting | Dompé Farmaceutici S.p.A | 153 | 2025-12-01 | 2026-09-21 |
| A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy INCA034176, Best Available Therapy (BAT) - Chronic Graft-versus-host-disease | Phase 3 | Active not recruiting | Incyte Corporation | 9 | 2025-06-04 | 2026-08-25 |
| A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203) Tacrolimus (Tac), Methotrexate (MTX), Ruxolitinib (Rux) - Graft-versus-host Disease (GVHD) | Phase 3 | Recruiting | Incyte Corporation | 572 | 2025-04-02 | 2026-10-22 |
| Hyaluronic Acid Mouthwash as Adjunct Hyaluoric acid mouthwash, Chlorhexidine 0,12% - Gingivitis; Chronic | Phase 3 | Completed | Cairo University | 16 | 2025-02-01 | 2026-01-26 |
| A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease INCA034176, Placebo, Corticosteroids - Chronic Graft-versus-host-disease | Phase 3 | Recruiting | Incyte Corporation | 240 | 2025-01-21 | 2026-11-13 |
| A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Axatilimab Monotherapy in Japanese Participants With Recurrent or Refractory Active Chronic Graft-Versus-Host Disease INCA034176 - Chronic Graft-versus-host-disease | Phase 3 | Active not recruiting | Incyte Biosciences Japan GK | 21 | 2024-07-30 | 2026-10-05 |
| A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease. Belumosudil, Placebo, Prednisone - Chronic Graft Versus Host Disease | Phase 3 | Active not recruiting | Sanofi | 260 | 2024-01-23 | 2026-10-16 |
| Efficacy of Vitamin D Supplementation for Children With Bronchiolitis Vitamin D3 - Bronchiolitis | Phase 2 / Phase 3 | Completed | Sohag University | 146 | 2023-04-01 | 2024-10-29 |
| Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults Azithromycin Oral Tablet, Placebo - Sinusitis, Chronic, Sinus Infection Chronic | Phase 3 | Recruiting | Centre Hospitalier Intercommunal Creteil | 230 | 2022-11-21 | 2025-08-29 |
| Characterization of Bronchodilator Response in Children With Bronchiolitis Using Phenotypic and Genotypic Features Albuterol Sulfate, 2.5 Mg/3 mL (0.083%) Inhalation Solution, Sodium Chloride 0.9% Inhl 3Ml - Bronchiolitis, Bronchodilator Agents | Phase 3 | Recruiting | Nemours Children's Clinic | 400 | 2022-07-08 | 2026-05-08 |
| Nebulised 3% Hypertonic Saline in Infants With Acute Bronchiolitis 3% Sodium Chloride, Standard care - Acute Bronchiolitis | Phase 2 / Phase 3 | Completed | Can Tho University of Medicine and Pharmacy | 140 | 2022-06-01 | 2024-08-16 |
| Efficacy of Magnesium Sulfate Bolus in Pediatric Patients With Bronchiolitis Magnesium Sulfate - Bronchiolitis, Viral | Phase 2 / Phase 3 | Withdrawn | University of Louisville | 2021-07-21 | 2026-05-11 | |
| Efficacy of Fluticasone Propionate Associated With Salmeterol Using Inhalation Chamber Versus Placebo to Improve the Respiratory Function in Children Over Six Years of Age Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation With a Decline of FEV1 ≥10% From Pre Transplantation Seretide, Placebo - Stem Cell Transplant Complications, Respiratory Disease | Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 35 | 2021-05-21 | 2025-09-16 |
| Extension Trial on Efficacy / Safety of L-CsA + SoC in Treating BOS in Post Single or Double Lung Transplant (BOSTON-3) Liposomal Cyclosporine A 5 mg, Liposomal Cyclosporine A 10 mg - Bronchiolitis Obliterans, Obliterative Bronchiolitis | Phase 3 | Terminated | Zambon SpA | 164 | 2020-03-12 | 2026-04-07 |
| Nintedanib in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome Grade 0p-1-2 Nintedanib, Placebo - Lung-transplant Recipients | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 58 | 2019-10-30 | 2025-09-08 |
| Study of Efficacy and Safety of Erenumab in Adult Chronic Migraine Patients Erenumab, Placebo - Migraine | Phase 3 | Completed | Novartis Pharmaceuticals | 557 | 2019-08-26 | 2025-10-16 |
| High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients. 4-Aminopyridine, Placebo oral capsule - Spinal Cord Injuries, Chronic | Phase 3 | Unknown | Coordinación de Investigación en Salud, Mexico | 150 | 2019-07-17 | 2021-02-21 |
| Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1) Liposomal Cyclosporine A, standard of care - Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant | Phase 3 | Completed | Zambon SpA | 62 | 2019-03-26 | 2025-10-27 |
| Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2) Liposomal Cyclosporine A, Standard of Care - Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant | Phase 3 | Completed | Zambon SpA | 169 | 2019-03-26 | 2026-02-10 |
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Bronchiolitis Obliterans Syndrome (86) · Bronchiolitis Obliterans (12) · Pain (9) · Constipation (8) · Lymphoma, Follicular (8) · Psoriasis (7) · Leukemia (6) · Hepatitis C (5) · Migraine Disorders (5) · Pruritus (5) · Graft vs Host Disease (4) · Headache (4) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (4) · Low Back Pain (4)
Lung Diseases (124) · Bronchial Diseases (123) · Lung Diseases, Obstructive (123) · Respiratory Tract Diseases (122) · Bronchitis (121) · Immune System Diseases (87) · Organizing Pneumonia (86) · Bronchiolitis Obliterans (83) · Graft vs Host Disease (82) · Pathological Conditions, Signs and Symptoms (55) · Infections (44) · Signs and Symptoms (36) · Respiratory Tract Infections (31) · Neurologic Manifestations (22)
Sodium Chloride (8) · tofacitinib (7) · Imatinib Mesylate (6) · Prednisone (5) · Saline Solution (5) · Tacrolimus (5) · ibrutinib (5) · Cyclosporine (4) · Mycophenolic Acid (4) · Standard of Care (4) · Azithromycin (3) · Everolimus (3) · Methotrexate (3) · Photopheresis (3) · Saline Solution, Hypertonic (3)
Pfizer (8) · Assistance Publique - Hôpitaux de Paris (6) · Novartis Pharmaceuticals (6) · Incyte Corporation (5) · Baqiyatallah Medical Sciences University (4) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (4) · Gilead Sciences (3) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (3) · Zambon SpA (3) · APT Pharmaceuticals, Inc. (2) · AstraZeneca (2) · Foundation for Liver Research (2) · GlaxoSmithKline (2) · Hoffmann-La Roche (2) · International Centre for Diarrhoeal Disease Research, Bangladesh (2)
United States (40) · France (32) · Germany (32) · Canada (25) · Spain (25) · United Kingdom (25) · Belgium (21) · Italy (18) · Netherlands (17) · Poland (17) · Australia (16) · Austria (16) · Denmark (14) · Israel (14) · Hungary (13)
Mary Horowitz, MD (2) · Mostafa Ghanei, MD (2) · Paola Castellani, MD (2) · Alan Jackson, MB, BS (1) · Albert Assad, MD (1) · Allan Glanville, MD, PhD (1)
PMID 32816215, PMID 26149717, PMID 28396102, PMID 36791280, PMID 38696034, PMID 12563043, PMID 15121942, PMID 16352625, PMID 17300356, PMID 17999759, PMID 18668692, PMID 19860762, PMID 21183326, PMID 21943218, PMID 22147778, PMID 22645182, PMID 23380743, PMID 23668548, PMID 24139233, PMID 24268590, PMID 24382580, PMID 24410959, PMID 24521787, PMID 24862623, PMID 24881631, PMID 24928639, PMID 25038354, PMID 25404569, PMID 25418186, PMID 25583164, PMID 25788164, PMID 25835160, PMID 26051365, PMID 26182309, PMID 26233481, PMID 26278222, PMID 26286532, PMID 26743093, PMID 26784000, PMID 26871197, PMID 27271195, PMID 27538247, PMID 27724916, PMID 27890073, PMID 28373262, PMID 28390869, PMID 28558833, PMID 28558978, PMID 28564569, PMID 28586918
2018 (4), 2015 (3), 2008 (2), 2014 (2), 2016 (2), 2023 (2), U01HL069294 (2), 2019 (1), 2025 (1), U01AT001908 (1), U01IP000127 (1), U24CA076518 (1)