10 recruiting, 9 completed, 3 not yet recruiting, 3 unknown. 9 Not applicable, 3 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Recruiting 4, Not yet recruiting 3, Completed 1, Unknown 1 |
| Phase 4 | 3 | Completed 2, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow Brain Disease: new trials by email Literature Review of Brain Disease trials Research Report on Brain Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Brain Iron in Beta-Propeller Protein Associated Neurodegeneration (BPAN) Standardized brain MRI including specific sequences usable for Quantitative Susceptibility Mapping (QSM) - Neurodegeneration With Brain Iron Accumulation (NBIA), Iron Metabolism Disorders | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 3 | 2026-12-01 | 2026-10-09 |
| Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke Stroke, Brain Disease | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 450 | 2026-09-14 | 2026-09-29 | |
| Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke Deep Brain Stimulation (DBS) of the Motor Thalamus - Stroke, Brain Disease | Not applicable | Recruiting | Jorge Gonzalez-Martinez | 10 | 2025-06-20 | 2026-05-08 |
| Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot) - Aging, Brain Metabolic Disorder | Not applicable | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 140 | 2025-04-01 | 2025-03-25 |
| Clinical Translation of a Novel Brain PET Insert for Simultaneous PET/MR Injected radiotracer with PET Insert, Pre-injected group with PET insert - Brain Disease | Not applicable | Recruiting | Stanford University | 40 | 2025-04-01 | 2025-04-06 |
| 18F-DPA-714 PET/MR in Dysfunctional Brain Diseases 18F-DPA-714 PET/MR scan - Brain Disease | Not applicable | Not yet recruiting | Xijing Hospital | 65 | 2025-03-01 | 2025-02-28 |
| Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study Rehabilitation program based on Physiotherapy, occupational therapy and swallow and language therapy - STROKE, Rehabilitation Outcome | Recruiting | Parc de Salut Mar | 213 | 2024-11-11 | 2025-12-15 | |
| Investigating the Neural Signature of Freezing of Gait in Parkinson's Disease Parkinson Disease, Freezing of Gait | Enrolling by invitation | KU Leuven | 28 | 2024-11-04 | 2025-02-24 | |
| Study of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Brain-first and Body-first PD Clinical assessments, Phenotypic classification - Parkinson Disease, Parkinsonian Disorders | Recruiting | Azienda USL Reggio Emilia - IRCCS | 150 | 2024-09-04 | 2026-04-23 | |
| A Prospective, Experimental, Multicenter, Open-label, Randomized, Controlled Trial of 3-month Dual Antiplatelet Therapy Followed by Ticagrelor Versus 6-month Dual Antiplatelet Therapy Followed by Ticagrelor After Implanting Bridge Ticagrelor - Brain Disease, Vertebral Artery Stenosis | Not applicable | Unknown | The Fourth Affiliated Hospital of China Medical University | 560 | 2023-12-05 | 2024-03-08 |
| Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality Sleep Disturbance, Aging | Completed | Chinese University of Hong Kong | 238 | 2023-10-01 | 2025-01-14 | |
| SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery Vericiguat, Placebo - Endothelial Dysfunction, Vascular Diseases | Phase 4 | Recruiting | Vanderbilt University Medical Center | 170 | 2023-05-19 | 2026-08-06 |
| Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function Deep Brain Stimulation (DBS) of the Motor Thalamus - Traumatic Brain Injury, Stroke | Not applicable | Recruiting | Jorge Gonzalez-Martinez | 60 | 2022-05-10 | 2026-09-18 |
| Efficacy of Erenumab in Chronic Cluster Headache Erenumab, Placebo - Cluster Headache, Trigeminal Autonomic Cephalalgias | Phase 2 | Completed | Charite University, Berlin, Germany | 101 | 2021-12-02 | 2024-01-23 |
| Experiment on the Use of Innovative Computer Vision Technologies for Analysis of Medical Images in the Moscow Healthcare System AI (Artificial Intelligence), Mammary Cancer | Unknown | Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department | 133000 | 2020-02-21 | 2023-05-26 | |
| Brain Connections for Arm Movement After Stroke Transcranial Magnetic Stimulation - Stroke, Brain Disease | Not applicable | Recruiting | VA Office of Research and Development | 76 | 2020-01-10 | 2026-06-02 |
| Temporal Disorders in Left and Right Brain-Damaged Patients Rightward Attentional Shift (R-PA), Leftward Attentional Shift (L-PA) - Brain Disease | Completed | Istituti Clinici Scientifici Maugeri SpA | 74 | 2019-02-01 | 2023-08-14 | |
| Detection of Silent Atrial Fibrillation aFter Ischemic StrOke Reveal LINQTM- LNQ11 Internal Loop Recorder plus standard cardiac monitoring - Ischemic Stroke, Cerebral Infarction | Not applicable | Completed | Danilo Toni | 317 | 2015-10-01 | 2023-06-29 |
| Inflammatory and Infectious Diseases of the Nervous System Brain Disease | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 1000 | 2015-05-06 | 2026-10-16 | |
| PET Imaging in Chronic Traumatic Encephalopathy Brain Disease, Brain Mapping | Completed | National Institute of Mental Health (NIMH) | 6 | 2014-08-01 | 2018-07-05 |
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Brain Diseases (27) · Stroke (8) · Central Nervous System Diseases (4) · Nervous System Diseases (4) · Vascular Diseases (4) · Cerebrovascular Disorders (3) · Cognitive Dysfunction (3) · Movement Disorders (3) · Basal Ganglia Diseases (2) · Cardiovascular Diseases (2) · Cerebral Infarction (2) · Lung Neoplasms (2) · Neurodegenerative Diseases (2) · Neuroinflammatory Diseases (2) · Parkinson Disease (2)
Central Nervous System Diseases (23) · Nervous System Diseases (23) · Cardiovascular Diseases (9) · Pathological Conditions, Signs and Symptoms (9) · Cerebrovascular Disorders (7) · Vascular Diseases (7) · Mental Disorders (6) · Pathologic Processes (6) · Neurocognitive Disorders (4) · Brain Ischemia (3) · Cognition Disorders (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Signs and Symptoms (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2)
Deep Brain Stimulation (2) · Deglutition (1) · Language Therapy (1) · Occupational Therapy (1) · Ticagrelor (1) · Transcranial Magnetic Stimulation (1) · erenumab (1) · gadobenic acid (1) · gadobutrol (1) · gadoterate meglumine (1) · gadoteridol (1) · vericiguat (1)
National Institute of Neurological Disorders and Stroke (NINDS) (4) · National Institute of Mental Health (NIMH) (3) · Bracco Diagnostics, Inc (2) · Jorge Gonzalez-Martinez (2) · Azienda USL Reggio Emilia - IRCCS (1) · Charite University, Berlin, Germany (1) · Chinese University of Hong Kong (1) · Danilo Toni (1) · Insel Gruppe AG, University Hospital Bern (1) · Istituti Clinici Scientifici Maugeri SpA (1) · KU Leuven (1) · National Institute of Cancerología (1) · Parc de Salut Mar (1) · Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department (1) · Stanford University (1)
United States (14) · Italy (3) · Belgium (1) · China (1) · France (1) · Germany (1) · Hong Kong (1) · Mexico (1) · Russia (1) · Spain (1) · Switzerland (1)
Gianpaolo Pirovano, MD (2) · Robert B Innis, M.D. (2) · Anna Guillen-Sola, MD, PHd (1) · Anton Vladzymyrskyy (1) · Avindra Nath, M.D. (1) · Digna Pachuca, MD (1) · Francesca Frassinetti, PhD (1) · Gabriela Mercado, MSc (1) · George F. Wittenberg, MD PhD (1) · Hanna LU, PhD (1)
PMID 16627797, PMID 20813995, PMID 23124133, PMID 23280267, PMID 25300984, PMID 25569470, PMID 27145936, PMID 2760661, PMID 28965738, PMID 29749279, PMID 30598741, PMID 31238830, PMID 31238832, PMID 34986727, PMID 35156393, PMID 35264400, PMID 38078378, PMID 39401519, PMID 40436255, PMID 40526384, PMID 41641924, PMID 41882580, PMID 42379717, PMID 42593056
2023 (1), R01HL164909 (1)