77 completed, 35 unknown, 19 recruiting, 16 terminated. 51 Not applicable, 37 Phase 2, 21 Phase 3, 15 Phase 1, 5 Phase 4.
Follow Bone Metastases: new trials by email Literature Review of Bone Metastases trials Research Report on Bone Metastases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Regional Database for Collecting Clinical-biological and Imaging Data "Secondary Bone Oncology and Bone Localizations of Hematologic Diseases" Bone Metastases | Withdrawn | University Hospital, Lille | 2026-12-01 | 2026-05-15 | ||
| Impact of Prophylactic Bone Radiation Therapy in Patients With Bone Metastases. prophylactic radiation, standard of care - Bone Metastases | Phase 3 | Not yet recruiting | Centre Henri Becquerel | 154 | 2026-09-01 | 2026-07-29 |
| Surgery vs. No Surgery for Primary Tumor in De Novo Stage IV Breast Cancer With Solitary Bone Metastases Primary Tumor Resection, Standard systemic therapy - Breast Cancer, Stage IV Breast Cancer | Not applicable | Not yet recruiting | West China Hospital | 216 | 2026-09-01 | 2026-07-07 |
| Prophylactic Radiotherapy to Prevent Bone Complications in Patients With Metastatic Solid Cancers Prophylactic External Beam Radiotherapy, Standard of Care - Bone Metastases, Metastatic Solid Tumor | Phase 2 | Recruiting | Institute of Oncology Ljubljana | 90 | 2026-06-02 | 2026-10-09 |
| Denosumab Strategy for Liver Cancer With Bone Metastases Denosumab, Sintilimab, Delayed/Rescue Bone-Modifying Strategy - Hepatocellular Carcinoma (HCC), Bone Metastases | Phase 2 | Not yet recruiting | Tongji Hospital | 50 | 2026-05-01 | 2026-04-17 |
| Registry for Bone Metastases Bone Metastases | Recruiting | Memorial Sloan Kettering Cancer Center | 500 | 2026-01-13 | 2026-08-20 | |
| Simulation-Free, Single-Fraction Palliative Radiation Therapy for Treatment of Bone Metastases simulation-free, single-fraction palliative radiation therapy - Bone Metastases | Not applicable | Recruiting | University of Utah | 40 | 2025-11-03 | 2026-08-13 |
| Validation of Whole Body PET/CT Foundation Model Bone Metastases | Not yet recruiting | Shanghai 6th People's Hospital | 180 | 2025-10-16 | 2025-10-03 | |
| Dual Energy CT - a Tool for Delineation of Tumor and Organs at Risk in Radiotherapy Dual-energy CT (DECT), Iodine-based contrast agent, Magnetic Resonance Imaging (MRI) - Brain Metastases, Bone Metastases | Not yet recruiting | Aalborg University Hospital | 80 | 2025-09-22 | 2025-09-22 | |
| BOne Metastases REgistry for Patients Undergoing cryoAbLation With curatIve purpoSe Cryoablation system - Bone Metastases | Recruiting | Cardiovascular and Interventional Radiological Society of Europe | 50 | 2025-04-01 | 2025-12-30 | |
| Early Radiotherapy Versus Observation for High-risk Asymptomatic or Minimally Symptomatic Bone Metastases Preventive radiotherapy, Systemic therapy (Standard of Care)/Observation - Solid Neoplasms, Bone Metastases | Not applicable | Recruiting | Cancer Research Antwerp | 120 | 2025-02-05 | 2026-01-20 |
| EXercise Enhancement After RadioTherapy for Bone Metastases Exercise Program - Bone Metastases | Not applicable | Enrolling by invitation | University Health Network, Toronto | 20 | 2025-01-13 | 2026-04-13 |
| Risk Model for Metastasis Detection of Neuroblastoma risk model in diagnosis and prognosis - Neuroblastoma (NB), Prognosis | Enrolling by invitation | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 500 | 2024-12-01 | 2025-05-15 | |
| Fracture Risk Evaluation of Bone Metastases Derived From Carcinoma Analysis - Bone Metastases | Recruiting | Costantino Errani | 250 | 2024-09-23 | 2025-12-15 | |
| EPIBONE Study: a Prospective Study on Feasibility, Safety and Accuracy CT-guided bone percutaneous procedure - Bone Metastases, Fractures, Bone | Not applicable | Completed | Quantum Surgical | 34 | 2024-09-16 | 2025-09-22 |
| Tislelizumab Combined with Nab-Paclitaxel for First-Line Treatment of Advanced Triple-Negative Breast Cancer with Bone Metastasis，an Exploratory, Single-Arm, Multicenter Phase II Clinical Study Tislelizumab + Nab-Paclitaxel, Rankl inhibitor - Triple-negative Breast Cancer, Bone Metastases | Phase 2 | Recruiting | Zhejiang Cancer Hospital | 20 | 2024-08-20 | 2024-11-26 |
| A Study for Dynamic Prediction Model of Breast Cancer Bone Metastases Breast cancer patients with bone metastasis, Breast cancer patients without bone metastasis - Breast Cancer, Bone Metastases | Unknown | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 3500 | 2024-08-06 | 2024-08-09 | |
| Safety of ArcBlate MRgHIFU in Patients With Painful Bone Metastases: An Extension Study ArcBlate Focused Ultrasound Ablation System - Bone Metastases | Not applicable | Unknown | EpiSonica | 25 | 2024-08-01 | 2024-07-05 |
| MR Guided Focused Ultrasound vs Radiotherapy for Palliative Pain Tx in Bone Metastases MR- High intensity focused ultrasound, External beam radiotherapy - Bone Metastases | Not applicable | Withdrawn | Stanford University | 2024-06-01 | 2024-10-01 | |
| Analysis of Intramedullary Nail and Prosthetic Reconstruction After Surgical Treatment of Bone Metastases of Proximal Femur Analysis - Bone Metastases | Recruiting | Costantino Errani | 600 | 2024-05-30 | 2026-05-22 |
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Breast Neoplasms (30) · Prostatic Neoplasms (27) · Neoplasms (17) · Bone Neoplasms (16) · Neoplasm Metastasis (15) · Pain (14) · Lung Neoplasms (12) · Cancer Pain (6) · Carcinoma, Non-Small-Cell Lung (5) · Fractures, Bone (5) · Multiple Myeloma (5) · Sarcoma (5) · Bone Diseases (3) · Carcinoma, Hepatocellular (3) · Fractures, Spontaneous (3)
Neoplasms (72) · Neoplasms by Site (72) · Pathological Conditions, Signs and Symptoms (33) · Breast Diseases (31) · Skin Diseases (31) · Skin and Connective Tissue Diseases (31) · Male Urogenital Diseases (30) · Urogenital Diseases (30) · Urogenital Neoplasms (29) · Genital Diseases (27) · Genital Diseases, Male (27) · Genital Neoplasms, Male (27) · Prostatic Diseases (27) · Signs and Symptoms (21) · Pathologic Processes (20)
Zoledronic Acid (10) · Denosumab (9) · radium Ra 223 dichloride (9) · Radiotherapy (5) · Magnetic Resonance Spectroscopy (4) · Radiation (4) · Radiosurgery (4) · Radium-223 (3) · Technetium Tc 99m Medronate (3) · enzalutamide (3) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (2) · Aspirin (2) · Cryosurgery (2) · Enoxaparin (2) · Fracture Fixation, Internal (2)
M.D. Anderson Cancer Center (7) · InSightec (6) · Bayer (5) · UMC Utrecht (5) · Amgen (4) · Fudan University (4) · Istituto Ortopedico Rizzoli (4) · National Cancer Institute (NCI) (4) · Shanghai 6th People's Hospital (4) · Hospices Civils de Lyon (3) · Assiut University (2) · City of Hope Medical Center (2) · Costantino Errani (2) · EpiSonica (2) · European Institute of Oncology (2)
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Andre Bergman, MD, PhD (2) · Francesco Cellini, MD (2) · Helena M. Verkooijen, MD, PhD (2) · Naoto Ueno, MD, PhD (2) · Wilfried De Neve, MD, PhD (2) · A KL Reyners, MD, PhD (1) · AeRang Kim, MD, PhD (1) · Ajjai Alva, M.D. (1) · Alessio G Morganti, MD (1) · Alexander de Graeff, MD, PhD (1) · Alfredo Berruti, MD (1) · Alysa Fairchild (1)
PMID 22975218, PMID 23975226, PMID 26093811, PMID 27871280, PMID 18846565, PMID 20171515, PMID 20879569, PMID 21489705, PMID 22341993, PMID 23164174, PMID 24890347, PMID 25175042, PMID 25407874, PMID 25976743, PMID 26335402, PMID 26829933, PMID 27441744, PMID 29156912, PMID 33270906, PMID 18777528, PMID 19455472, PMID 20882405, PMID 21936956, PMID 22894553, PMID 22932804, PMID 23000088, PMID 23096187, PMID 23104043, PMID 23326203, PMID 23791392, PMID 23863050, PMID 23977665, PMID 24052017, PMID 24258798, PMID 24327518, PMID 24510426, PMID 24590644, PMID 24610703, PMID 24722180, PMID 24760791, PMID 24772219, PMID 24775727, PMID 24836273, PMID 24857093, PMID 24881730, PMID 24885354, PMID 25439694, PMID 25687533, PMID 25759599, PMID 25832684
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