5 completed, 3 active not recruiting, 2 not yet recruiting, 2 terminated. 12 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 5, Active not recruiting 3, Not yet recruiting 2, Terminated 2 |
| Phase 1 | 4 | Completed 2, Not yet recruiting 2 |
| Phase 3 | 1 | Terminated 1 |
Follow Bone Cancer: new trials by email Literature Review of Bone Cancer trials Research Report on Bone Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors. Dinutuximab beta, Sirolimus and Irinotecan - Osteosarcomas, Bone Cancer | Phase 1 / Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 89 | 2026-10-01 | 2026-10-01 |
| Treatment of Truncated ALK-positive Bone Cancer Using Crizotinib (Xalkori) or Alectinib (Alecensa) Alectinib - Bone Cancer | Phase 1 / Phase 2 | Not yet recruiting | China Medical University Hospital | 10 | 2026-05-15 | 2026-05-11 |
| Intra-arterial Cisplatin Plus Rh-endostatin Combined With Systematic Chemotherapy in Osteosarcoma intra-arterial cisplatin plus anti-angiogenesis inhibitor rh-endostatin (Endostar) - Osteosarcoma, Bone Cancer | Phase 1 / Phase 2 | Completed | Shanghai 6th People's Hospital | 10 | 2024-12-03 | 2025-12-29 |
| Osteosarcoma Maintenance Therapy With OST31-164 OST31-164 - Bone Cancer | Phase 2 | Active not recruiting | Emerald Clinical Inc. | 39 | 2021-10-21 | 2025-01-22 |
| Feasibility of Combined Focused Ultrasound and Radiotherapy Treatment in Patients With Painful Bone Metastasis combined radiotherapy and MR-HIFU - Bone Metastases, Bone Neoplasm | Phase 1 / Phase 2 | Completed | UMC Utrecht | 10 | 2019-04-11 | 2024-02-07 |
| 9-ING-41 in Patients With Advanced Cancers 9-ING-41, Gemcitabine - 21 day cycle, Doxorubicin. - Cancer, Pancreatic Cancer | Phase 2 | Active not recruiting | Actuate Therapeutics Inc. | 350 | 2019-01-04 | 2026-04-03 |
| Evaluating Stereotactic Body Radiation Therapy for Oligometastatic Disease of the Bone Stereotactic Body Radiation Therapy (SBRT), Stereotactic Linear Accelerator - Bone Cancer | Phase 2 | Active not recruiting | Dana-Farber Cancer Institute | 150 | 2016-11-29 | 2025-09-09 |
| Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Feraheme, Magnetic Resonance Imaging (MRI) scan - Bone Cancer, Chondrosarcoma | Phase 2 | Completed | Heike E Daldrup-Link | 32 | 2011-08-01 | 2023-12-27 |
| Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma Irinotecan, Vincristine, Temozolomide - Bone Cancer, Ewing's Sarcoma | Phase 2 | Terminated | Stanford University | 3 | 2011-05-01 | 2017-11-24 |
| Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System ExAblate 2100 - Bone Cancer, Bone Metastases | Phase 2 | Completed | InSightec | 50 | 2010-03-01 | 2016-03-08 |
| Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery therapeutic angiotensin-(1-7), laboratory biomarker analysis - Bone Cancer, Chondrosarcoma | Phase 2 | Completed | Wake Forest University Health Sciences | 20 | 2009-10-01 | 2018-07-05 |
| Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia Enbrel - Lung Cancer, Prostate Cancer | Phase 2 / Phase 3 | Terminated | The University of Texas Health Science Center at San Antonio | 54 | 2001-05-01 | 2012-06-26 |
Bone Neoplasms (12) · Osteosarcoma (5) · Neoplasm Metastasis (4) · Lung Neoplasms (3) · Neoplasms (3) · Breast Neoplasms (2) · Chondrosarcoma (2) · Pain (2) · Prostatic Neoplasms (2) · Sarcoma (2) · Sarcoma, Ewing (2) · Cancer Pain (1) · Colorectal Neoplasms (1) · Glioma (1) · Hereditary Sensory and Autonomic Neuropathies (1)
Bone Diseases (12) · Musculoskeletal Diseases (12) · Neoplasms by Site (12) · Neoplasms (9) · Neoplasms by Histologic Type (7) · Neoplasms, Connective and Soft Tissue (7) · Neoplasms, Bone Tissue (6) · Neoplasms, Connective Tissue (6) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Sarcoma (5) · Neoplastic Processes (4) · Lung Diseases (3) · Male Urogenital Diseases (3) · Respiratory Tract Diseases (3)
Irinotecan (3) · Doxorubicin (2) · 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-(1,3)dioxolo(4,5-f)indol-7-yl)-pyrrole-2,5-dione (1) · Albumin-Bound Paclitaxel (1) · Carboplatin (1) · Cyclophosphamide (1) · Etanercept (1) · Ferrosoferric Oxide (1) · Gemcitabine (1) · Lomustine (1) · Magnetic Resonance Spectroscopy (1) · Paclitaxel (1) · Radiosurgery (1) · Sirolimus (1) · Taxes (1)
Actuate Therapeutics Inc. (1) · China Medical University Hospital (1) · Dana-Farber Cancer Institute (1) · Emerald Clinical Inc. (1) · Heike E Daldrup-Link (1) · InSightec (1) · Shanghai 6th People's Hospital (1) · Stanford University (1) · The University of Texas Health Science Center at San Antonio (1) · UMC Utrecht (1) · University Hospital, Strasbourg, France (1) · Wake Forest University Health Sciences (1)
United States (7) · France (2) · Netherlands (2) · Belgium (1) · Canada (1) · China (1) · Israel (1) · Portugal (1) · Spain (1) · Taiwan (1)
Charles R Thomas, Jr, MD (1) · Heike E Daldrup-Link, MD (1) · Helena M Verkooijen, MD, PhD (1) · Hong-Tao Li, Dr. (1) · Kristen N. Ganjoo (1) · Neyssa Marina, MD (1) · Robert Petit, PhD (1) · Tracy Balboni, MD MPH (1) · William Petty (1)
PMID 24327518, PMID 27424289, PMID 28053024, PMID 28672195, PMID 29383130, PMID 29846250, PMID 30405781, PMID 30975030, PMID 31101621, PMID 31401903, PMID 31533931, PMID 31831767, PMID 31882719, PMID 31894292, PMID 35815408, PMID 41981308