3 completed, 3 terminated, 1 unknown. 3 Phase 1, 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Terminated 2, Completed 1 |
| Phase 2 | 2 | Terminated 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Infigratinib in Patients With Locally Advanced or Metastatic Gastric Cancer or GEJ Adenocarcinoma Infigratinib - Gastric Cancer, Gastroesophageal Junction Adenocarcinoma | Phase 2 | Terminated | LianBio LLC | 6 | 2023-10-19 | 2024-08-14 |
| BBP-398 in Combination With Osimertinib in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutations BBP-398, osimertinib - NSCLC | Phase 1 | Terminated | LianBio LLC | 4 | 2023-07-27 | 2024-06-25 |
| Trial to Evaluate the Efficacy and Safety of TP-03, LIBRA Study Lotilaner, Vehicle Control - Blepharitis | Phase 3 | Completed | LianBio LLC | 163 | 2022-10-23 | 2024-05-21 |
| Phase I Study of the BBP-398 in Patients With Advance Solid Tumors BBP-398 - Advanced Solid Tumor, Advanced or Metastatic Non-small Cell Lung Cancer | Phase 1 | Terminated | LianBio LLC | 7 | 2022-10-18 | 2024-06-25 |
| A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCM Mavacamten, Placebo - Obstructive Hypertrophic Cardiomyopathy | Phase 3 | Completed | LianBio LLC | 81 | 2022-01-04 | 2024-09-19 |
| Study Evaluating the Pharmacokinetics of Mavacamten in Healthy Adult Chinese Subjects Mavacamten - Hypertrophic Cardiomyopathy | Phase 1 | Completed | LianBio LLC | 45 | 2021-10-31 | 2024-07-25 |
| Infigratinib in Subjects With GC or GEJ With FGFR2 Amplification or Other Solid Tumors With Other FGFR Alterations Infigratinib - Gastric Cancer, Gastroesophageal Junction Adenocarcinoma | Phase 2 | Unknown | LianBio LLC | 80 | 2020-05-13 | 2022-06-27 |
Cardiomyopathy, Hypertrophic (2) · Stomach Neoplasms (2) · Acrocephalosyndactylia (1) · Blepharitis (1) · Carcinoma, Non-Small-Cell Lung (1)
MYK-461 (2) · infigratinib (2) · lotilaner (1) · osimertinib (1)
China (7)
Li Zhang, Master (2) · Jing Zhang, Doctor (1) · Qiao Sun, Doctor (1) · Shuyang Zhang, M.D., Ph.D. (1) · Yongsheng Wang, Doctor (1) · Zuguo Liu, M.D (1)
PMID 37336533, PMID 37639259, PMID 39014868, PMID 40299193, PMID 40632050, PMID 42165935, PMID 42179278, PMID 42337043, PMID 42636950