12 completed, 7 unknown, 4 recruiting, 3 active not recruiting. 7 Not applicable, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 3, Active not recruiting 1, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 2 | 1 | Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Bicuspid Aortic Valve: new trials by email Literature Review of Bicuspid Aortic Valve trials Research Report on Bicuspid Aortic Valve
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial transcatheter aortic valve replacement (TAVR), surgical aortic valve replacement (SAVR) - Aortic Valve Stenosis, Bicuspid Aortic Valve | Not applicable | Recruiting | Cedars-Sinai Medical Center | 250 | 2025-01-31 | 2025-02-10 |
| NavIIcusp: Bicuspid Aortic Valve Stenosis With Navitor Platform International Experience Transcatheter Aortic Valve Implantation - Bicuspid Aortic Valve | Unknown | Didier TCHETCHE | 150 | 2024-05-01 | 2024-04-19 | |
| Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes Surgery on the proximal aorta (aortic root +/- ascending aorta), Patients diagnosed with thoracic aortopathy but not operated upon - Aortic Diseases, Aortic Dissection | Unknown | Golden Jubilee National Hospital | 1662 | 2023-12-18 | 2024-07-15 | |
| Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve Bicuspid Aortic Valve | Recruiting | Yonsei University | 240 | 2023-10-19 | 2023-12-01 | |
| Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis Transcatheter Aortic Valve Implantation - Aortic Stenosis, Transcatheter Aortic Valve Implantation | Unknown | National University of Ireland, Galway, Ireland | 200 | 2023-09-15 | 2024-06-21 | |
| Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV) Laser doppler vibrometry (LDV), heart(cordium) carotid pulse wave velocity (ccPWV), Blood pressure and heart rate measurement, carotid to femoral PWW measurement - Hypertension, Aortic Aneurysm | Not applicable | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 100 | 2023-03-13 | 2025-08-29 |
| Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement. Echocardiographic assessment., Computed-tomography assessment - Bicuspid Aortic Valve, Aortic Valve Stenosis | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 150 | 2023-01-20 | 2023-02-01 | |
| A Multicentre Retrospective Study on Bicuspid Aortic Valve Bicuspid Aortic Valve | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 1000 | 2022-12-01 | 2023-04-19 | |
| Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement Transcatheter aortic valve replacement - Aortic Stenosis, Ascending Aortic Dilatation | Recruiting | China National Center for Cardiovascular Diseases | 480 | 2022-03-22 | 2025-02-10 | |
| The CASPER Registry TAVI - Bicuspid Aortic Valve | Not applicable | Completed | University of Pisa | 100 | 2021-07-01 | 2025-01-28 |
| Fate at Long-term of Mild to Moderate Bicuspid Aortic Valve Disease Left Untreated at the Time of Supracoronary Ascending Aorta Replacement Ascending aorta replacement - Bicuspid Aortic Valve, Ascending Aorta Aneurysm | Completed | Michele De Bonis | 75 | 2020-12-04 | 2023-05-01 | |
| Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride clinical evaluation, blood markers, pulse wave analysis, 18F sodium fluoride PET/CT and PET/MRI, Repeat 18F sodium fluoride PET/MRI - Bicuspid Aortic Valve, Thoracic Aortic Aneurysm | Completed | University of Edinburgh | 95 | 2019-04-01 | 2023-11-29 | |
| Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging Magnetic Resonance Imaging, Transthoracic echocardiography, Echography UltraFast - Bicuspid Aortic Valve | Not applicable | Completed | French Cardiology Society | 100 | 2018-11-07 | 2025-02-14 |
| Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study Medtronic TAVR Systems - Bicuspid Aortic Valve | Not applicable | Active not recruiting | Medtronic Cardiovascular | 150 | 2018-10-30 | 2026-05-05 |
| BIVOLUTX: Bicuspid Aortic Stenosis With Evolut Platform International Experience. Transcatheter Aortic Valve Implantation - Bicuspid Aortic Valve | Completed | Clinique Pasteur | 150 | 2018-06-05 | 2026-06-18 | |
| Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry Transcatheter aortic valve replacement - Bicuspid Aortic Valve | Recruiting | Cedars-Sinai Medical Center | 2000 | 2016-08-15 | 2019-02-11 | |
| Bicuspid Aortic Valve Stenosis and the Effect of vItamin K2 on Calciummetabolism on 18F-NaF PET/MRI Vitamin K2, Placebo - Aortic Valve Stenosis, Bicuspid Aortic Valve | Phase 2 | Unknown | Maastricht University Medical Center | 44 | 2016-08-01 | 2018-03-22 |
| Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve Atorvastatin, Placebo - Bicuspid Aortic Valve | Phase 3 | Completed | Hospital Universitari Vall d'Hebron Research Institute | 220 | 2016-06-01 | 2021-02-18 |
| Pathogenetic Basis of Aortopathy and Aortic Valve Disease Aortopathies, Thoracic Aortic Aneurysm | Active not recruiting | Yale University | 3000 | 2015-12-10 | 2026-02-13 | |
| Whole Exome Sequencing in Bicuspid Aortic Valve Patients Extra blood draw samples, additional tissue samples - Bicuspid Aortic Valve | Not applicable | Unknown | Assistance Publique Hopitaux De Marseille | 427 | 2014-01-01 | 2016-09-14 |
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Bicuspid Aortic Valve Disease (28) · Aortic Valve Stenosis (5) · Aortic Aneurysm (4) · Aortic Aneurysm, Thoracic (4) · Marfan Syndrome (4) · Aneurysm, Ascending Aorta (3) · Aortic Dissection (2) · Aortic Valve Insufficiency (2) · Heart Diseases (2) · Loeys-Dietz Syndrome (2) · Turner Syndrome (2) · Aortic Aneurysm, Familial Thoracic 1 (1) · Aortic Aneurysm, Giant Congenital (1) · Aortic Diseases (1) · Aortic Valve Disease (1)
Cardiovascular Abnormalities (28) · Cardiovascular Diseases (28) · Congenital Abnormalities (28) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (28) · Aortic Valve Disease (27) · Heart Defects, Congenital (27) · Heart Valve Diseases (27) · Heart Diseases (26) · Aneurysm (9) · Vascular Diseases (9) · Aortic Diseases (8) · Aortic Aneurysm (5) · Ventricular Outflow Obstruction (5) · Abnormalities, Multiple (4) · Bone Diseases (4)
Transcatheter Aortic Valve Replacement (6) · Atorvastatin (1) · Blood Pressure (1) · Echocardiography (1) · Heart Rate (1) · Losartan (1) · Magnetic Resonance Imaging (1) · Physical Examination (1) · Pulse Wave Analysis (1) · Tomography, X-Ray Computed (1) · Vitamin K 2 (1)
Cedars-Sinai Medical Center (2) · University of Michigan (2) · Assistance Publique Hopitaux De Marseille (1) · Boston University (1) · China National Center for Cardiovascular Diseases (1) · Clinique Pasteur (1) · Didier TCHETCHE (1) · Emory University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · French Cardiology Society (1) · Golden Jubilee National Hospital (1) · Gruppo di Ricerca GISSI (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Maastricht University Medical Center (1)
United States (10) · France (5) · Italy (4) · China (2) · United Kingdom (2) · Denmark (1) · Germany (1) · Ireland (1) · Netherlands (1) · South Korea (1) · Spain (1) · Sweden (1)
Alexander J Fletcher, MD (1) · Andreas Ruck, MD (1) · Anna Booher, MD (1) · Arturo Evangelista-Masip, MD, PhD, Professor (1) · Attilio Maseri, MD (1) · Bas Kietselaer, M.D. PhD (1) · Basel Ramlawi, MD (1) · Benjamin Landis, MD (1) · Bo Yang, MD (1) · Christian Trolle (1) · Claus H Gravholt, MD, Ph.d. (1) · Darren Mylotte, MD, PhD (1) · Denver Sallee, MD (1)
PMID 30626202, PMID 32854836, PMID 33031491, PMID 37203860, PMID 38804148, PMID 39658198, PMID 39702010, PMID 40209757, PMID 42217733
R21HL150373 (1), R34HL115032 (1)