26 completed. 26 Phase 2, 3 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 26 | Completed 26 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 3 | Completed 3 |
Follow Ataxia: new trials by email Literature Review of Ataxia trials Research Report on Ataxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sirolimus Treatment in Pediatric Patients With Ataxia-Telangiectasia Rapamune (sirolimus/rapamycin) - Ataxia-Telangiectasia (A-T), Ataxia-Telangiectasia | Phase 2 | Completed | Sara Elva Espinosa Padilla, MD | 6 | 2024-07-11 | 2026-09-15 |
| Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis Triheptanoin - Ataxia Telangiectasia | Phase 2 | Completed | The University of Queensland | 30 | 2022-03-15 | 2023-07-20 |
| Chinese Medicine WT for Spinocerebellar Ataxia Type 3 Chinese medicine WT - Ataxia, Spinocerebellar, Insulin-Like Growth Factor I | Phase 2 | Completed | Changhua Christian Hospital | 33 | 2021-05-31 | 2023-01-31 |
| Effects of Vitamin B3 in Patients With Ataxia Telangiectasia Vitamin B3 - Ataxia Telangiectasia, ATM Gene Mutation | Phase 2 | Completed | Radboud University Medical Center | 24 | 2019-03-18 | 2022-07-25 |
| Effect of Nilotinib in Cerebellar Ataxia Patients Nilotinib - Ataxia, Cerebellar, Ataxia, Progressive | Phase 2 | Completed | Seoul National University Hospital | 70 | 2018-11-19 | 2021-09-29 |
| A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome dantrolene sodium - Wolfram Syndrome, Diabetes Mellitus | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 21 | 2017-01-01 | 2024-03-13 |
| Trial in Adult Participants With Spinocerebellar Ataxia (SCA) Troriluzole, Placebo - Spinocerebellar Ataxias, Spinocerebellar Ataxia Genotype Type 1 | Phase 2 / Phase 3 | Completed | Biohaven Pharmaceuticals, Inc. | 141 | 2016-12-15 | 2025-10-08 |
| A Safety Study of NNZ-2566 in Pediatric Rett Syndrome NNZ-2566, Placebo - Rett Syndrome | Phase 2 | Completed | Neuren Pharmaceuticals Limited | 82 | 2016-03-01 | 2020-08-14 |
| Efficacy and Safety Study of Stemchymal® in Polyglutamine Spinocerebellar Ataxia Stemchymal®, Excipients - Cerebellar Ataxia | Phase 2 | Completed | Steminent Biotherapeutics Inc. | 56 | 2015-09-01 | 2022-10-27 |
| Study To Assess Safety, Tolerability and Efficacy of Intravenous Cabaletta in Patients With Machado-Joseph Disease Cabaletta for IV infusion once weekly during 24 weeks - Machado-Joseph Disease / Spinocerebellar Ataxia 3 | Phase 2 | Completed | Bioblast Pharma Ltd. | 15 | 2014-07-01 | 2016-11-22 |
| The Influence of Deep TMS on Cerebellar Signs in Patients With Machado Joseph Disease Deep TMS - Machado Joseph Disease (SCA3) | Phase 2 | Completed | Brainsway | 20 | 2014-02-01 | 2018-01-25 |
| Evaluation of the Tolerability of Switching Subjects on Chronic ATC Opioid Therapy to Buprenorphine HCl Buccal Film Buprenorphine, Placebo film, Oxycodone - Pain | Phase 2 | Completed | BioDelivery Sciences International | 39 | 2013-06-01 | 2017-02-27 |
| A Safety Study of NNZ-2566 in Patients With Rett Syndrome NNZ-2566, Placebo - Rett Syndrome | Phase 2 | Completed | Neuren Pharmaceuticals Limited | 67 | 2013-03-01 | 2018-02-05 |
| Efficacy Study of Epoetin Alfa in Friedreich Ataxia Epoetin alfa, Placebo - Friedreich Ataxia | Phase 2 | Completed | Federico II University | 56 | 2013-01-01 | 2015-08-11 |
| Safety and Efficacy of EPI-743 in Patients With Friedreich's Ataxia Placebo, EPI-743 400 mg, EPI-743 200 mg - Friedreich's Ataxia | Phase 2 | Completed | PTC Therapeutics | 60 | 2012-12-31 | 2020-08-31 |
| Treatment of Cerebellar Ataxia With Mesenchymal Stem Cells Allogeneic adult adipose-derived mesenchymal stem cells - Cerebellar Ataxia | Phase 1 / Phase 2 | Completed | National Yang Ming Chiao Tung University | 7 | 2012-05-01 | 2014-09-12 |
| Safety and Efficacy of Intravenous Immune Globulin in Treating Spinocerebellar Ataxia IVIG - Spinocerebellar Ataxia | Phase 2 | Completed | University of South Florida | 5 | 2011-08-01 | 2013-07-23 |
| Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3 Lithium Carbonate, Placebo - Spinocerebellar Ataxia Type 3, Machado Joseph Disease | Phase 2 / Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 62 | 2011-05-01 | 2013-01-30 |
| Efficacy of Riluzole in Hereditary Cerebellar Ataxia riluzole, Placebo comparator - Cerebellar Ataxia | Phase 2 / Phase 3 | Completed | S. Andrea Hospital | 60 | 2010-04-01 | 2015-04-21 |
| Safety and Tolerability of Lithium in Spinocerebellar Ataxia 2 (SCA2) LITHIUM CARBONATE - SPINOCEREBELLAR ATAXIA 2 | Phase 2 | Completed | Federico II University | 20 | 2009-10-01 | 2013-01-08 |
Showing 20 of 26. Sign in to see all of them.
Spinocerebellar Ataxias (8) · Cerebellar Ataxia (6) · Ataxia Telangiectasia (5) · Friedreich Ataxia (4) · Machado-Joseph Disease (4) · Autistic Disorder (2) · Rett Syndrome (2) · Spinocerebellar Degenerations (2) · Blast Crisis (1) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Carcinoma, Ovarian Epithelial (1) · Congenital Abnormalities (1) · Diabetes Mellitus (1)
Dyskinesias (26) · Nervous System Diseases (26) · Neurologic Manifestations (26) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Genetic Diseases, Inborn (24) · Central Nervous System Diseases (23) · Brain Diseases (22) · Cerebellar Diseases (22) · Heredodegenerative Disorders, Nervous System (20) · Neurodegenerative Diseases (19) · Pathological Conditions, Signs and Symptoms (16) · Spinal Cord Diseases (16) · Signs and Symptoms (15) · Spinocerebellar Degenerations (14)
Immunoglobulins, Intravenous (2) · Lithium Carbonate (2) · Riluzole (2) · trofinetide (2) · Buprenorphine (1) · Caspofungin (1) · Dantrolene (1) · Epoetin Alfa (1) · Excipients (1) · Injections (1) · Morphine (1) · Niacinamide (1) · Oxycodone (1) · Rituximab (1) · Sirolimus (1)
Federico II University (2) · National Institute of Neurological Disorders and Stroke (NINDS) (2) · Neuren Pharmaceuticals Limited (2) · S. Andrea Hospital (2) · University of South Florida (2) · BioDelivery Sciences International (1) · Bioblast Pharma Ltd. (1) · Biohaven Pharmaceuticals, Inc. (1) · Brainsway (1) · Changhua Christian Hospital (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Hospital de Clinicas de Porto Alegre (1) · National Pediatric Neuroinflammation Organization, Inc. (1) · National Yang Ming Chiao Tung University (1) · PTC Therapeutics (1)
United States (11) · Italy (5) · Taiwan (3) · Israel (2) · Australia (1) · Belgium (1) · Brazil (1) · France (1) · Germany (1) · Mexico (1) · Netherlands (1) · Slovakia (1) · South Korea (1) · Switzerland (1) · Turkey (Türkiye) (1)
Alan Percy, MD (2) · Carlos Gordon, Prof. (2) · Theresa Zesiewicz, MD (2) · Timothy Feyma, MD (2) · Alessandro Filla, MD (1) · Arthur Beisang, MD (1) · Claudio Viscoli, MD (1) · Daniel G Glaze, M.D. (1) · Daniel Glaze, MD (1) · David Coman, MBBS FRACP (1) · Eric Marsh, MD (1) · Fumihiko Urano, MD (1) · Giovanni Ristori, MD (1) · Jeff Neul, MD (1)
PMID 37460385, PMID 38363467, PMID 16763896, PMID 16934683, PMID 17826341, PMID 19838774, PMID 19841031, PMID 20090835, PMID 20599042, PMID 20606544, PMID 21211990, PMID 22144182, PMID 22875082, PMID 22927201, PMID 24236946, PMID 24399647, PMID 25656498, PMID 26297649, PMID 26321318, PMID 26433381, PMID 26547562, PMID 26851119, PMID 28601294, PMID 28871440, PMID 28969699, PMID 29110179, PMID 30586396, PMID 30796268, PMID 30948626, PMID 33437944, PMID 34115419, PMID 34185708, PMID 39009709
R21DK113487 (1)