11 completed, 6 recruiting, 3 terminated, 1 active not recruiting. 24 Phase 2, 4 Phase 1, 3 Phase 3.
Follow Arteriovenous Malformations: new trials by email Literature Review of Arteriovenous Malformations trials Research Report on Arteriovenous Malformations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT) ATV-1601, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT), Osler Weber Rendu Disease | Phase 1 / Phase 2 | Recruiting | Atavistik Bio, Inc | 100 | 2026-07-27 | 2026-11-06 |
| A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies Everolimus - Vascular Malformations, Arteriovenous Malformations | Phase 2 | Not yet recruiting | Yonsei University | 67 | 2026-04-01 | 2026-03-17 |
| Efficacy and Safety of Anti-angiogenic Therapy With IV Bevacizumab in Patients With Symptomatic Cerebral Arteriovenous Malformations Bevacizumab, Placebo - Cerebral AV Malformation | Phase 2 / Phase 3 | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 54 | 2026-01-16 | 2026-01-22 |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| Pilot Study on Trametinib for Surgical Unruptured AVMs Trametinib tablet - Arteriovenous Malformations | Phase 2 | Withdrawn | University Health Network, Toronto | 2024-01-30 | 2026-05-22 | |
| Cobimetinib In Extracranial Arteriovenous Malformations (COBI-AVM Study) Cobimetinib - Arteriovenous Malformations (Extracranial) | Phase 2 | Completed | University of Arkansas | 3 | 2022-07-26 | 2026-11-12 |
| Assess Safety and Efficacy of VAD044 in HHT Patients VAD044 Part I, VAD044 Part II - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 / Phase 2 | Active not recruiting | Vaderis Therapeutics AG | 75 | 2022-07-18 | 2026-03-17 |
| Lovastatin for Treatment of Brain Arteriovenous Malformations Lovastatin, Placebo - Cerebral Arteriovenous Malformation | Phase 2 | Unknown | Beijing Tiantan Hospital | 1244 | 2021-01-01 | 2020-03-09 |
| UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions Cognitive Sparing Brain Stereotactic Radiosurgery (SRS) - Brain Metastases, Adult, Neurocognitive Function | Phase 2 | Recruiting | Jona Hattangadi-Gluth | 90 | 2019-05-01 | 2026-09-08 |
| Low-dose Intra-arterial Bevacizumab for Edema and Radiation Necrosis Therapeutic Intervention (LIBERTI) 25% Mannitol, Low-dose Intra-arterial Bevacizumab - Radiation Necrosis | Phase 2 | Completed | Norton Healthcare | 10 | 2016-11-23 | 2022-05-24 |
| The LIPMAT Study: Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation PEG-liposomal prednisolone sodium phosphate, Placebo - Renal Dialysis, Hemodynamics | Phase 2 | Terminated | Leiden University Medical Center | 30 | 2015-11-01 | 2018-09-18 |
| Vorapaxar Study for Maturation of AV Fistulae for Hemodialysis Access Vorapaxar sulfate, Placebo - AV Fistula | Phase 2 | Completed | Ken Mahaffey | 17 | 2015-08-26 | 2019-01-14 |
| Proton Radiotherapy for Primary Central Nervous System Tumours in Adults Proton radiotherapy - Central Nervous System Tumour, Arteriovenous Malformation | Phase 2 | Recruiting | Uppsala University | 500 | 2015-08-01 | 2016-06-13 |
| Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations Sirolimus - Arteriovenous Malformations | Phase 2 | Recruiting | Centre Hospitalier Universitaire, Amiens | 50 | 2014-09-12 | 2026-05-13 |
| An Efficacy and Safety Study of SRM003 in the Treatment of Subjects Undergoing Creation of an Arteriovenous Fistula to Facilitate Hemodialysis Access SRM003, Participating Site's standard practice - Arteriovenous Fistula | Phase 2 | Completed | Shire | 64 | 2013-03-26 | 2021-06-08 |
| Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula Rosuvastatin - End-stage Kidney Disease, Diabetes Mellitus | Phase 2 | Completed | National Cheng-Kung University Hospital | 60 | 2012-11-01 | 2019-02-19 |
| Safety and Efficacy Study of the Venous Window Needle Guide to Access Arteriovenous (AV)Fistulae Venous Window Needle Guide - End Stage Renal Disease, AV Fistula | Phase 2 / Phase 3 | Completed | Vital Access Corp. | 54 | 2011-12-01 | 2016-06-03 |
| Efficacy and Local Tolerability of Topically Applied Heparin on the Suitability of Newly Constructed Primary Arteriovenous Fistulas in Patients Planned for Haemodialysis Heparin 2,400 IU /ml Cutaneous Spray, Placebo Cutaneous Spray - Haemodialysis | Phase 2 | Terminated | Cyathus Exquirere Pharmaforschungsgmbh | 30 | 2011-07-01 | 2014-05-08 |
| A Study of PRT-201 Administered Immediately After Arteriovenous Fistula Creation in Patients With Chronic Kidney Disease PRT-201, Placebo - Chronic Kidney Disease | Phase 2 | Completed | Proteon Therapeutics | 151 | 2011-03-01 | 2015-04-30 |
| Reducing Hemodialysis Catheter Use in Prevalent Hemodialysis Patients Protocolized approach to convert dialysis catheter to fistula - Hemodialysis | Phase 2 | Terminated | Dr. Lisa Miller | 3 | 2009-02-01 | 2014-04-17 |
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Arteriovenous Fistula (11) · Intracranial Arteriovenous Malformations (3) · Kidney Failure, Chronic (3) · Renal Insufficiency, Chronic (3) · Telangiectasia, Hereditary Hemorrhagic (3) · Vascular Malformations (3) · Fistula (2) · Lymphangioma (2) · Angiodysplasia (1) · Brain Neoplasms (1) · Bunion (1) · Cardiovascular Diseases (1) · Diabetes Mellitus (1) · Dilatation, Pathologic (1)
Cardiovascular Abnormalities (24) · Congenital Abnormalities (24) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Cardiovascular Diseases (23) · Vascular Diseases (23) · Vascular Malformations (21) · Pathological Conditions, Signs and Symptoms (13) · Pathological Conditions, Anatomical (11) · Vascular Fistula (11) · Fistula (9) · Pathologic Processes (9) · Chronic Disease (6) · Disease Attributes (6) · Female Urogenital Diseases (6)
Bevacizumab (2) · cholesterol-binding protein (2) · Alpelisib (1) · Capsules (1) · Everolimus (1) · Gelatin Sponge, Absorbable (1) · Heparin (1) · Injections (1) · Lovastatin (1) · Mannitol (1) · Rosuvastatin Calcium (1) · Sirolimus (1) · Thalidomide (1) · cobimetinib (1) · fospropofol (1)
Proteon Therapeutics (2) · Atavistik Bio, Inc (1) · Beijing Tiantan Hospital (1) · Centre Hospitalier Universitaire, Amiens (1) · Cyathus Exquirere Pharmaforschungsgmbh (1) · Dr. Lisa Miller (1) · Eisai Inc. (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Jona Hattangadi-Gluth (1) · Ken Mahaffey (1) · Leiden University Medical Center (1) · Murdoch Childrens Research Institute (1) · National Cheng-Kung University Hospital (1) · Northport Veterans Affairs Medical Center (1) · Norton Healthcare (1)
United States (13) · France (3) · Belgium (2) · Canada (2) · Netherlands (2) · Argentina (1) · Australia (1) · Austria (1) · China (1) · Italy (1) · Spain (1) · Sweden (1) · Taiwan (1)
Atul Kumar, MD (1) · Damien Picard (1) · Ivan Radovanovic, MD PhD (1) · James B Jones, MD, PharmD (1) · James Gossage, MD (1) · Joana M Mack, MD (1) · Jona Hattangadi-Gluth, MD (1) · Joris I Rotmans, MD PhD (1) · Jun-Neng Roan, MD, PhD (1) · Justin Fraser, MD (1) · Kenneth W Mahaffey, MD (1) · Kevin J Bielamowicz, MD, (1) · Lisa M Miller, MD (1)
PMID 23172172, PMID 24684771, PMID 24833247, PMID 35426830, PMID 40148035, PMID 41297007
R01CA238783 (1)