6 completed, 1 active not recruiting, 1 not yet recruiting, 1 recruiting. 11 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 6, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 4 | Completed 2, Active not recruiting 1, Recruiting 1 |
Follow Arteriovenous Malformations: new trials by email Literature Review of Arteriovenous Malformations trials Research Report on Arteriovenous Malformations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT) ATV-1601, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT), Osler Weber Rendu Disease | Phase 1 / Phase 2 | Recruiting | Atavistik Bio, Inc | 100 | 2026-07-27 | 2026-10-29 |
| A Trial of TER-1754 in Patients With Hereditary Hemorrhagic Telangiectasia TER-1754, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 | Withdrawn | Terremoto Biosciences Inc. | 2025-12-15 | 2026-04-13 | |
| In Situ Injection of Anti-angiogenics in Patients With Brain Arteriovenous Malformations Not Eligible for Exclusion Treatment Single in situ intra-arterial injection of bevacizumab - Brain Arteriovenous Malformations | Phase 1 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 20 | 2025-10-01 | 2025-07-20 |
| Assess Safety and Efficacy of VAD044 in HHT Patients VAD044 Part I, VAD044 Part II - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 / Phase 2 | Active not recruiting | Vaderis Therapeutics AG | 75 | 2022-07-18 | 2026-03-17 |
| COmbiNing Cutting and Drug-Eluting Balloon for Resistant Arteriovenous Fistula sTenOsis (CONCERTO) Angioplasty - Arteriovenous Fistula Stenosis | Phase 1 | Completed | Singapore General Hospital | 19 | 2018-08-15 | 2023-07-27 |
| Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB 68Ga-NEB - Arteriovenous Malformation, Hemangioma | Phase 1 | Unknown | Peking Union Medical College Hospital | 70 | 2014-01-01 | 2017-04-07 |
| A Phase 1-2 Study of PRT-201 Administered in Chronic Kidney Disease (CKD) Patients PRT-201 - Chronic Kidney Disease | Phase 1 / Phase 2 | Completed | Proteon Therapeutics | 66 | 2008-11-01 | 2015-04-30 |
| Influence of MMP on Brain AVM Hemorrhage Doxycycline or Placebo - Arteriovenous Malformations, Cavernous Angiomas | Phase 1 | Completed | University of California, San Francisco | 33 | 2008-03-01 | 2013-08-09 |
| Safety of Vascugel Treatment After Creation of Arteriovenous Access for Hemodialysis Use Vascugel, Placebo Comparator - Hemodialysis Access | Phase 1 / Phase 2 | Completed | Pervasis Therapeutics, Inc | 65 | 2006-07-01 | 2011-10-27 |
| Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms minocycline, doxycycline - Aneurysms, Arteriovenous Malformations | Phase 1 | Completed | University of California, San Francisco | 26 | 2004-07-01 | 2013-10-09 |
| Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Marimastat - Vascular Anomalies | Phase 1 | Completed | Boston Children's Hospital | 9 | 2000-10-01 | 2008-01-09 |
Arteriovenous Fistula (3) · Telangiectasia, Hereditary Hemorrhagic (3) · Vascular Malformations (2) · Anemia (1) · Aneurysm (1) · Cardiovascular Diseases (1) · Constriction, Pathologic (1) · Disease (1) · Epistaxis (1) · Fistula (1) · Hemangioma (1) · Hemangioma, Cavernous (1) · Hematologic Diseases (1) · Hemorrhagic Disorders (1)
Cardiovascular Abnormalities (11) · Congenital Abnormalities (11) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Cardiovascular Diseases (10) · Vascular Diseases (10) · Vascular Malformations (9) · Hemic and Lymphatic Diseases (6) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4) · Hematologic Diseases (3) · Hemorrhagic Disorders (3) · Hemostatic Disorders (3) · Pathological Conditions, Anatomical (3) · Vascular Fistula (3)
Doxycycline (2) · 68Ga-1,4,7-triazacyclononane-N,N',N''-triacetic acid (1) · Angioplasty (1) · Capsules (1) · Minocycline (1) · Single Person (1) · cholesterol-binding protein (1) · marimastat (1)
University of California, San Francisco (2) · Assistance Publique - Hôpitaux de Paris (1) · Atavistik Bio, Inc (1) · Boston Children's Hospital (1) · Peking Union Medical College Hospital (1) · Pervasis Therapeutics, Inc (1) · Proteon Therapeutics (1) · Singapore General Hospital (1) · Terremoto Biosciences Inc. (1) · Vaderis Therapeutics AG (1)
United States (8) · France (2) · Belgium (1) · China (1) · Italy (1) · Netherlands (1) · Singapore (1) · Spain (1)
Chanhung Lee, MD (1) · Damien Picard (1) · Fang Li, Dr. (1) · Kun Da Zhuang, MBBS (1) · Steven J Fishman, M.D. (1) · William L. Young, MD (1)
PMID 18212521, PMID 23172172, PMID 41297007
2023 (1), ZIAEB000073 (1)