6 completed, 2 not yet recruiting, 2 unknown, 1 suspended. 13 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 6, Not yet recruiting 2, Unknown 2, Suspended 1, Terminated 1, Withdrawn 1 |
| Phase 2 | 7 | Completed 4, Not yet recruiting 1, Unknown 1, Withdrawn 1 |
Follow Aplastic Anemia: new trials by email Literature Review of Aplastic Anemia trials Research Report on Aplastic Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Prophylactic NAC to Improve Platelet Engraftment After Haploidentical Transplantation in Severe Aplastic Anemia Patients N-acetylcysteine - Aplastic Anemia | Phase 3 | Not yet recruiting | Peking University People's Hospital | 142 | 2026-09-30 | 2026-09-16 |
| A Study of Avatrombopag in Adults With Aplastic Anemia Who Did Not Respond to, Cannot Receive, or Had Return of Disease After Standard Treatment Avatrombopag 20 mg Oral Tablet - Aplastic Anemia | Phase 2 / Phase 3 | Not yet recruiting | Swedish Orphan Biovitrum | 26 | 2026-07-31 | 2026-08-26 |
| Efficacy and Safety of Hetrombopag in Non-severe Aplastic Anemia Hetrombopag - Aplastic Anemia, Drug Effect | Phase 2 / Phase 3 | Withdrawn | Peking Union Medical College Hospital | 2021-10-01 | 2026-06-08 | |
| Avatrombopag Usage in NSAA Avatrombopag 20 MG - Aplastic Anemia, Drug Effect | Phase 2 / Phase 3 | Unknown | Peking Union Medical College Hospital | 40 | 2021-02-01 | 2021-01-28 |
| A Study to Assess Efficacy and Safety of PF-06462700 in Japanese Participants With Aplastic Anemia PF-06462700 - Aplastic Anemia | Phase 3 | Completed | Pfizer | 3 | 2020-07-25 | 2022-04-27 |
| Study of AMG531 (Romiplostim) in Patients With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 24 | 2019-12-03 | 2022-05-26 |
| Study of AMG531(Romiplostim) in Patients With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 17 | 2019-04-25 | 2022-05-26 |
| Study of Romiplostim(AMG531) in Subjects With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 46 | 2016-05-01 | 2024-07-16 |
| Trial of Two Central Venous Catheter (CVC) Flushing Schemes in Pediatric Hematology and Oncology Patients Heparin, Normal saline - Childhood Cancer, Aplastic Anemia | Phase 3 | Terminated | Alberta Children's Hospital | 2 | 2011-04-01 | 2012-05-30 |
| Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Cy-ATG, Flu-ATG - Aplastic Anemia | Phase 3 | Unknown | Cooperative Study Group A for Hematology | 98 | 2010-03-01 | 2012-09-07 |
| Stem Cell Transplant (SCT) for Dyskeratosis Congenita or SAA Campath 1H, Cyclophosphamide, Fludarabine - Dyskeratosis Congenita, Aplastic Anemia | Phase 2 / Phase 3 | Completed | Masonic Cancer Center, University of Minnesota | 36 | 2007-08-01 | 2017-12-05 |
| Phase III Randomized Study of Cyclophosphamide With or Without Antithymocyte Globulin Before Bone Marrow Transplantation in Patients With Aplastic Anemia Anti-thymocyte globulin, Cyclophosphamide, Bone marrow transplantation - Aplastic Anemia | Phase 3 | Completed | Roswell Park Cancer Institute | 224 | 1998-09-01 | 2018-03-12 |
Anemia, Aplastic (13) · Bone Marrow Failure Disorders (2) · Neoplasms (2) · Disease (1) · Dyskeratosis Congenita (1) · Hematologic Diseases (1) · Leukemia (1) · Metabolic Diseases (1) · Mucositis (1) · Pain, Intractable (1) · Rare Diseases (1) · Recurrence (1)
Anemia (13) · Bone Marrow Diseases (13) · Hemic and Lymphatic Diseases (13) · Hematologic Diseases (12) · Bone Marrow Failure Disorders (11) · Pathological Conditions, Signs and Symptoms (3) · Disease Attributes (2) · Pathologic Processes (2) · Congenital Abnormalities (1) · Congenital Bone Marrow Failure Syndromes (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Digestive System Diseases (1) · Gastroenteritis (1) · Gastrointestinal Diseases (1) · Genetic Diseases, Inborn (1)
Cyclophosphamide (3) · romiplostim (3) · Antilymphocyte Serum (2) · Bone Marrow Transplantation (2) · avatrombopag (2) · fludarabine (2) · thymoglobulin (2) · Acetylcysteine (1) · Alemtuzumab (1) · Heparin (1) · Hydromorphone (1) · Methadone (1) · Methylprednisolone (1) · Morphine (1) · Passive Cutaneous Anaphylaxis (1)
Kyowa Kirin Co., Ltd. (3) · Peking Union Medical College Hospital (2) · Alberta Children's Hospital (1) · Cooperative Study Group A for Hematology (1) · Masonic Cancer Center, University of Minnesota (1) · Peking University People's Hospital (1) · Pfizer (1) · Roswell Park Cancer Institute (1) · Swedish Orphan Biovitrum (1) · University of Texas Southwestern Medical Center (1)
Japan (4) · United States (3) · China (2) · South Korea (2) · Canada (1)
Bing Han, Master (1) · Hawk Kim, professor (1) · Jakub Tolar, M.D., Ph.D. (1) · Martin A Campbell, MBBS FRACP (1) · Victor M Aquino, MD (1)
PMID 20383216, PMID 22526363, PMID 36441357, PMID 37318085, PMID 40593138