33 completed, 17 unknown, 11 terminated, 6 recruiting. 74 Phase 2, 13 Phase 3, 6 Phase 1.
Follow Ankylosis: new trials by email Literature Review of Ankylosis trials Research Report on Ankylosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vilamakitug in Spondyloarthritis Placebo-controlled Investigation for Efficacy vilamakitug, placebo - Axial Spondyloarthritis, Ankylosing Spondylitis | Phase 2 | Not yet recruiting | XBiotech, Inc. | 150 | 2026-09-01 | 2026-05-14 |
| A Phase I/Ⅱ Clinical Trial for Umbilical Cord Mesenchymal Stem Cells (UC-MSC) in the Treatment of Ankylosing Spondylitis HS_SW01 cells injection - Ankylosing Spondylitis | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Huishan Biotechnology Co., Ltd. | 18 | 2026-04-10 | 2026-04-20 |
| Efficacy and Safety of Xeligekimab in the Treatment of Non-Radiographic Axial Spondyloarthritis Xeligekimab injection - Nr-axial Spondyloarthritis, Non-Radiographical Axial Spondyloarthritis | Phase 2 / Phase 3 | Not yet recruiting | Lingli Dong | 40 | 2026-01-31 | 2026-01-14 |
| Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty Methotrexate, Sulfasalazine, Hydroxychloroquine - Rheumatic Disease | Phase 2 | Recruiting | NYU Langone Health | 80 | 2025-12-12 | 2026-07-09 |
| A Study of SPY072 in Rheumatic Disease SPY002-072, Placebo - Rheumatoid Arthritis, Psoriatic Arthritis | Phase 2 | Active not recruiting | Spyre Therapeutics, Inc. | 285 | 2025-08-21 | 2026-06-05 |
| EAST-1 (ERAP-inhibition in Axial Spondyloarthritis Trial - 1) Part A - Single Ascending Dose (SAD) in Healthy Human Volunteers, Part B - Multiple Ascending Dose (MAD) in participants with axSpA, Part C - Safety expansion cohort in participants with axSpA - Axial Spondyloarthritis (AxSpA) | Phase 1 / Phase 2 | Recruiting | Grey Wolf Therapeutics | 140 | 2025-07-28 | 2026-11-12 |
| Mesenchymal Stem Cells Infusion in Patients With Autoimmune Diseases Mesenchymal Stem Cells, Placebo - Rheumatoid Arthritis, Systemic Lupus Erythematosus (SLE) | Phase 1 / Phase 2 | Enrolling by invitation | National Institute of Blood and Marrow Transplant (NIBMT), Pakistan | 200 | 2025-02-01 | 2025-03-21 |
| Efficacy and Safety of SCT650C in Participants With Axial Spondyloarthritis SCT650C - Axial Spondyloarthritis | Phase 2 | Unknown | Sinocelltech Ltd. | 168 | 2024-07-01 | 2024-01-09 |
| Fecal Microbiota Transplantation in Axial Spondyloarthritis FMT, Placebo - Axial Spondyloarthritis, Ankylosing Spondylitis | Phase 2 | Recruiting | University Hospital of North Norway | 99 | 2024-06-01 | 2026-08-14 |
| The Efficacy of Fecal Microbiota Transplatation on Axial Spondyloarthritis Patients Resistant to Conventional Treatment active FMT, Placebo - Axial Spondyloarthritis | Phase 2 / Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 20 | 2024-03-28 | 2024-04-09 |
| A Study to Evaluate 608 in Patients With Non- Radiographic Axial Spondyloarthritis (Nr-axSpA) 608, Placebo - Axial Spondyloarthritis | Phase 2 | Recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 180 | 2024-03-22 | 2025-03-11 |
| A Study to Evaluate 608 in Patients with Ankylosing Spondylitis (AS) 608 Dose A, 608 Dose B, 608 Dose C - Ankylosing Spondylitis | Phase 2 | Unknown | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 250 | 2024-03-19 | 2024-10-23 |
| A Clinical Study of JS005 in Patients With Ankylosing Spondylitis Recombinant humanized IL-17A Monoclonal Antibody（JS005）, Placebo（JS005） - Ankylosing Spondylitis | Phase 2 | Completed | Shanghai Junshi Bioscience Co., Ltd. | 265 | 2024-01-13 | 2026-07-20 |
| Safety and Efficacy of Capsule FMT in Treatment-naïve Patients With Newly Diagnosed Chronic Inflammatory Diseases Faecal microbiota transplantation, Placebo - Rheumatoid Arthritis, Ankylosing Spondylitis | Phase 2 | Recruiting | Odense University Hospital | 200 | 2023-12-13 | 2025-12-05 |
| Baricitinib in the Treatment of Refractory Axial Spondyloarthritis Patients: A Comparison With Tofacitinib Baricitinib 2mg, Tofacitinib 5 mg - Spondyloarthritis, Axial | Phase 2 | Unknown | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 184 | 2023-10-30 | 2023-12-21 |
| Effect of Osteopathy Medicine on Post-surgical Management of Lumbosacral Arthrodesis manual therapy, Sham - Arthrodesis, Post-operative Care | Phase 2 | Completed | Centre Européen d'Enseignement Supérieur de l'Ostéopathie de Lyon | 35 | 2023-03-01 | 2024-11-01 |
| Study of the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of BCD-180 in Patients With Axial Spondyloarthritis anti-TRBV9 monoclonal antibody, low dose, anti-TRBV9 monoclonal antibody, high dose, placebo - Axial Spondyloarthritis | Phase 2 | Active not recruiting | Biocad | 250 | 2022-04-19 | 2023-04-18 |
| A Study of LNK01001 Capsule in Patients With Ankylosing Spondylitis LNK01001, Placebo - Ankylosing Spondylitis | Phase 2 | Completed | Lynk Pharmaceuticals Co., Ltd | 177 | 2022-01-06 | 2023-10-27 |
| Evaluate the Preliminary Efficacy, Safety, and PK of Subcutaneous JS005 in Chinese Adult Patients With Active Nr-axSpA JS005, Placebo - Non-radiographic Axial Spondyloarthritis | Phase 2 | Terminated | Shanghai Junshi Bioscience Co., Ltd. | 23 | 2021-12-31 | 2026-07-21 |
| A Study of CC-99677 in Participants With Active Ankylosing Spondylitis CC-99677, Placebo - Spondylitis, Ankylosing | Phase 2 | Terminated | Celgene | 167 | 2021-08-25 | 2024-05-01 |
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Spondylitis, Ankylosing (57) · Axial Spondyloarthritis (15) · Arthritis, Rheumatoid (11) · Arthritis, Psoriatic (8) · Spondylarthritis (8) · Arthritis (6) · Non-Radiographic Axial Spondyloarthritis (6) · Spondylitis (5) · Arthritis, Juvenile (3) · Crohn Disease (3) · Joint Diseases (3) · Lupus Erythematosus, Systemic (3) · Musculoskeletal Diseases (3) · Psoriasis (3)
Joint Diseases (71) · Musculoskeletal Diseases (71) · Bone Diseases (70) · Spinal Diseases (69) · Spondylarthropathies (68) · Arthritis (66) · Spondylitis (66) · Spondylarthritis (63) · Axial Spondyloarthritis (56) · Skin and Connective Tissue Diseases (13) · Connective Tissue Diseases (12) · Immune System Diseases (12) · Autoimmune Diseases (11) · Rheumatic Diseases (11)
Etanercept (5) · Adalimumab (4) · Sulfasalazine (4) · bimekizumab (4) · tofacitinib (4) · Meloxicam (3) · Abatacept (2) · Celecoxib (2) · Certolizumab Pegol (2) · GLPG0634 (2) · Infliximab (2) · Methotrexate (2) · Rituximab (2) · Saline Solution (2) · Ustekinumab (2)
Charite University, Berlin, Germany (8) · AbbVie (2) · Advanced Accelerator Applications (2) · Assistance Publique - Hôpitaux de Paris (2) · Biocad (2) · Lakefront Biotherapeutics NV (2) · Novartis Pharmaceuticals (2) · Pfizer (2) · Sanofi (2) · Shanghai Junshi Bioscience Co., Ltd. (2) · Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. (2) · UCB Biopharma SRL (2) · Akeso (1) · Amgen (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1)
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Joachim Sieper, MD (3) · Joachim Sieper, Prof. (3) · Aline Rollet, Ostéopathe DO, MsC Cand. (1) · Alison Heald, MD (1) · Asadul Islam, MBBS (1)
PMID 24476416, PMID 35833532, PMID 39890205, PMID 40194794, PMID 41807031, PMID 18576337, PMID 19587341, PMID 20231202, PMID 20461780, PMID 22265264, PMID 22984171, PMID 23625982, PMID 23686466, PMID 23786760, PMID 24035250, PMID 24389297, PMID 24550171, PMID 25028375, PMID 25140041, PMID 26248638, PMID 28130206, PMID 29100842, PMID 29615661, PMID 29945918, PMID 30360970, PMID 30472651, PMID 30480772, PMID 31025924, PMID 32173258, PMID 32253184, PMID 32433595, PMID 34196498, PMID 34352069, PMID 34570596, PMID 34647992, PMID 35614292, PMID 35829672, PMID 36058784, PMID 36138330, PMID 36754548, PMID 37137672, PMID 37162744, PMID 37331992, PMID 37909386, PMID 37945286, PMID 37982966, PMID 38683479, PMID 38696034, PMID 38825359, PMID 38942047
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