15 completed, 4 unknown, 1 active not recruiting, 1 not yet recruiting. 6 Phase 4, 5 Not applicable, 5 Phase 2, 5 Phase 3, 4 Phase 1.
Follow Sodium Citrate: new trials by email Literature Review of Sodium Citrate trials Research Report on Sodium Citrate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Impact of Nafamostat Mesylate on the Prognosis of Patients With Sepsis-Induced Coagulopathy Undergoing Hemofiltration Nafamostat Mesylate, sodium citrate - Sepsis-induced Coagulopathy (SIC) | Not applicable | Not yet recruiting | The First Hospital of Jilin University | 282 | 2025-07-01 | 2025-05-29 |
| Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric Population Caffeine citrate 15mg/kg, 0.9% Sodium Citrate - Enhanced Recovery After Surgery in a Pediatric Population | Phase 1 / Phase 2 | Recruiting | University of Chicago | 100 | 2024-09-09 | 2025-09-12 |
| Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction Sodium Citrate, Normal Saline, Olfactory Training Kit - "The Olfactory Kit, by AdvancedRx" - Long Haul COVID-19, Post-Acute COVID-19 Syndrome | Phase 2 | Active not recruiting | University of North Carolina, Chapel Hill | 60 | 2023-12-01 | 2025-02-20 |
| Litholytic Therapy for Coral Urate Nephrolithiasis anhydrous citric acid - 1197.0 mg, potassium bicarbonate - 967.5 mg, sodium citrate anhydrous - 835.5 mg - Urolithiasis | Not applicable | Completed | Moscow State University of Medicine and Dentistry | 49 | 2023-01-01 | 2025-09-09 |
| The Effectiveness and Safety of 4% Sodium Citrate as a Lock Solution in Central Venous Hemodialysis Catheter 4% sodium citrate, heparin group - Central Venous Catheter Thrombosis, Renal Dialysis | Phase 2 / Phase 3 | Unknown | Chang Gung Memorial Hospital | 120 | 2022-07-20 | 2022-07-25 |
| Sodium Citrate 4% Locking Solution for Children Requiring Home Parenteral Nutrition Sodium Citrate 4% Inj Syringe 3Ml - CLABSI - Central Line Associated Bloodstream Infection | Phase 4 | Terminated | Johns Hopkins University | 1 | 2022-03-28 | 2024-09-19 |
| Comparison of Biocompatibility of Plasmapheresis Procedures With Citrate and Heparin Anticoagulation unfractionated heparin, Sodium Citrate - Apheresis, Anticoagulation | Phase 4 | Completed | University Medical Centre Ljubljana | 15 | 2022-01-21 | 2023-11-29 |
| A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus Sodium Citrate, Treprostinil, Humalog diluent - Type 1 Diabetes Mellitus | Phase 1 | Completed | Eli Lilly and Company | 40 | 2021-10-22 | 2023-10-04 |
| The Impact of Air Travel on Passenger Cognitive Functions Citicoline, Cytochrome C6, Sodium Chloride Oral Product - Air Travel | Phase 2 / Phase 3 | Unknown | Dinara Zhumanbayeva | 50 | 2021-06-01 | 2021-03-17 |
| Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease Pravastatin, sodium citrate - Autosomal Dominant Polycystic Kidney Disease | Phase 2 | Completed | University of Southern California | 1 | 2019-01-30 | 2025-08-06 |
| The Impact of Different Citrate Concentrations as Locking Solutions on Development of Biofilm and Function of Hemodialysis Catheters 4% sodium citrate, 30% sodium citrate - End-Stage Kidney Disease, Renal Dialysis | Not applicable | Unknown | University Medical Centre Ljubljana | 50 | 2018-04-11 | 2018-09-25 |
| Efficacy of Three Toothpastes Using an in Situ Caries Model 0.425 % w/w phytate,1150ppm F, 0.85 % w/w phytate,1150ppm F, 0.85 % w/w phytate,0.3%ZnCl2 0.5% sodium citrate, 1150ppm F - Dental Caries | Not applicable | Completed | GlaxoSmithKline | 58 | 2016-02-01 | 2017-10-13 |
| Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m Sodium Citrate Dihydrate - Alkalosis | Phase 3 | Completed | Brock University | 10 | 2012-09-01 | 2014-07-24 |
| Caffeine and Sodium Citrate Ingestion Caffeine, Sodium Citrate, Mannitol - Dietary Supplements, Heart Rate/Drug Effects | Not applicable | Completed | Swiss Paraplegic Research, Nottwil | 9 | 2012-02-01 | 2016-11-22 |
| Regulating Urine pH Levels to Alleviate Chronic Joint Pain sodium citrate and citric acid - Arthritis | Phase 1 | Withdrawn | Texas Tech University Health Sciences Center, El Paso | 2011-07-01 | 2017-05-16 | |
| Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Adalimumab, Placebo - Psoriasis, Sleep Apnea, Obstructive | Phase 4 | Completed | Innovaderm Research Inc. | 20 | 2010-09-01 | 2011-10-28 |
| Study Using Citrate to Replace Heparin in Babies Requiring Extracorporeal Membrane Oxygenation (ECMO) sodium citrate - Heart Defects, Congenital, Respiratory Insufficiency | Early Phase 1 | Completed | Vanderbilt University | 2 | 2010-01-01 | 2015-06-03 |
| Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantation MabThera, Physiological serum (Sodium Chloride, sodium citrate) - Graft Rejection | Phase 3 | Unknown | University Hospital, Tours | 64 | 2008-10-01 | 2010-02-10 |
| Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantation MabThera, Physiological serum : sodium chloride, sodium citrate - Humoral Rejection in Kidney Transplantation | Phase 3 | Completed | University Hospital, Tours | 40 | 2008-10-01 | 2026-06-12 |
| Anaplerotic Therapy in Propionic Acidemia ornithine alpha ketoglutarate, glutamine, disodium citrate - Propionic Acidemia | Phase 1 | Completed | Nicola Longo | 3 | 2008-07-01 | 2015-01-21 |
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Heart Defects, Congenital (2) · Kidney Failure, Chronic (2) · Acidosis (1) · Alkalosis (1) · Anosmia (1) · Arthritis (1) · Bacteremia (1) · Bronchiolitis Obliterans Syndrome (1) · COVID-19 (1) · Conotruncal cardiac defects (1) · Dental Caries (1) · DiGeorge Syndrome (1) · Diabetes Mellitus, Type 1 (1) · Endocrine System Diseases (1) · Genetic Diseases, Inborn (1)
University Hospital, Tours (2) · University Medical Centre Ljubljana (2) · Brock University (1) · Chang Gung Memorial Hospital (1) · Dinara Zhumanbayeva (1) · Eli Lilly and Company (1) · GlaxoSmithKline (1) · Innovaderm Research Inc. (1) · Innovative Medical (1) · Johns Hopkins University (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1) · Moscow State University of Medicine and Dentistry (1) · National Center for Research Resources (NCRR) (1) · Nicola Longo (1) · Satellite Healthcare (1)
United States (11) · Canada (2) · France (2) · Slovenia (2) · Germany (1) · Russia (1) · Switzerland (1) · Taiwan (1)
Brent A. Senior, MD, FACS, FARS (1) · Claudio Perret, Dr. sc. nat. (1) · Craig B. Langman (1) · Darla Shores, MD (1) · Dennis W Miller, MD (1) · John B Pietsch, MD (1) · Nicola Longo, MD, PhD (1) · Norman Coplon, MD (1) · Nota Klentrou, PhD (1) · Rajnish Mehrotra, MD (1) · Robert Bissonnette, MD, FRCPC (1) · Thomas Kislan, OD (1)
PMID 19846545, PMID 24944546, PMID 26555944, PMID 28712602, PMID 36326260, PMID 42640289
R21DK077415 (1)