19 completed. 19 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 19 | Completed 19 |
| Phase 2 | 7 | Completed 7 |
Follow Adrenal Insufficiency: new trials by email Literature Review of Adrenal Insufficiency trials Research Report on Adrenal Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Plasma Exchange With Albumin in AMN Patients Albumin solution - Adrenomyeloneuropathy, Adrenoleukodystrophy | Phase 2 / Phase 3 | Completed | Pujol, Aurora, M.D. | 5 | 2020-03-09 | 2022-09-22 |
| Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock. Hydrocortisone + Flucortac, Placebo - Cardiogenic Shock | Phase 3 | Completed | CMC Ambroise Paré | 380 | 2019-04-19 | 2026-05-19 |
| A Clinical Study to Assess the Efficacy and Safety of Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy (CALD) Lenti-D - Cerebral Adrenoleukodystrophy (CALD) | Phase 3 | Completed | Genetix Biotherapeutics Inc. | 35 | 2019-01-24 | 2024-05-24 |
| Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Cosyntropin - Adrenal Insufficiency, Cirrhosis | Phase 3 | Completed | University of Virginia | 100 | 2018-01-29 | 2021-12-09 |
| A Clinical Study to Evaluate the Efficacy and Safety of MIN-102 (IMP) in Male AMN Patients Leriglitazone, Placebo - Adrenoleukodystrophy | Phase 2 / Phase 3 | Completed | Minoryx Therapeutics, S.L. | 116 | 2017-12-08 | 2026-10-28 |
| Extension Study for Patients Entered Into Study Infacort 003 Infacort® - Adrenal Insufficiency | Phase 3 | Completed | Neurocrine UK Limited | 18 | 2016-03-04 | 2026-10-02 |
| Treatment of Adrenal Insufficiency in Children Infacort® - Adrenal Insufficiency | Phase 3 | Completed | Neurocrine UK Limited | 24 | 2015-03-01 | 2026-10-02 |
| MD1003-AMN MD1003 in Adrenomyeloneuropathy MD1003 100 mg capsule, Placebo - Adrenomyeloneuropathy, Adrenoleukodystrophy | Phase 2 / Phase 3 | Completed | MedDay Pharmaceuticals SA | 67 | 2014-10-01 | 2017-10-09 |
| A Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD) Lenti-D Drug Product (eli-cel) - Cerebral Adrenoleukodystrophy (CALD) | Phase 2 / Phase 3 | Completed | Genetix Biotherapeutics Inc. | 32 | 2013-08-21 | 2022-04-25 |
| Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency dual-release hydrocortisone, Conventional glucocortidois - Adrenal Insufficiency | Phase 3 | Completed | University of Palermo | 88 | 2012-01-01 | 2024-02-15 |
| Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Placebo, Hydrocortisone Fludrocortisone - Traumatic Brain Injury, Trauma | Phase 3 | Completed | Nantes University Hospital | 336 | 2010-08-01 | 2017-09-14 |
| Glucocorticoid Treatment in Addison's Disease Solu-Cortef (hydrocortisone), Cortef (hydrocortisone) - Addison's Disease | Phase 2 / Phase 3 | Completed | Haukeland University Hospital | 33 | 2010-02-01 | 2013-03-20 |
| Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency hydrocortisone (modified release), oral tablet 20 and 5 mg, Hydrocortisone, oral tablet, 10 mg - Adrenal Insufficiency | Phase 2 / Phase 3 | Completed | Shire | 64 | 2007-08-21 | 2020-11-24 |
| Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock recombinant human insulin, hydrocortisone, fludrocortisone - Septic Shock | Phase 3 | Completed | University of Versailles | 508 | 2006-01-01 | 2010-04-06 |
| Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Dehydroepiandrosterone, placebo - Adrenal Insufficiency | Phase 3 | Completed | University Hospital Tuebingen | 23 | 2003-10-01 | 2007-12-18 |
| Corticosteroid Therapy of Septic Shock - Corticus hydrocortisone sodium succinate, Placebo - Shock, Septic | Phase 3 | Completed | Hadassah Medical Organization | 500 | 2002-03-01 | 2008-04-24 |
| Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency dehydroepiandrosterone - Addison's Disease | Phase 3 | Completed | National Center for Research Resources (NCRR) | 40 | 1995-08-01 | 2005-06-24 |
| Stem Cell Transplant for Inborn Errors of Metabolism Stem Cell Transplant, Busulfan, Cyclophosphamide, Antithymocyte Globulin - Adrenoleukodystrophy, Metachromatic Leukodystrophy | Phase 2 / Phase 3 | Completed | Masonic Cancer Center, University of Minnesota | 135 | 1995-01-01 | 2017-12-28 |
| Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Cholic Acids - Infantile Refsum's Disease, Zellweger Syndrome | Phase 3 | Completed | Mirum Pharmaceuticals, Inc. | 85 | 1992-01-01 | 2023-10-03 |
Adrenoleukodystrophy (7) · Addison Disease (3) · Shock, Septic (2) · Abetalipoproteinemia (1) · Brain Injuries, Traumatic (1) · Cholestasis (1) · Craniocerebral Trauma (1) · Endocrine System Diseases (1) · Fibrosis (1) · Fucosidosis (1) · Gangliosidosis, GM1 (1) · Gaucher Disease (1) · Lecithin Cholesterol Acyltransferase Deficiency (1) · Leukodystrophy, Globoid Cell (1)
Adrenal Gland Diseases (19) · Endocrine System Diseases (18) · Brain Diseases (8) · Central Nervous System Diseases (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Genetic Diseases, Inborn (8) · Metabolic Diseases (8) · Metabolism, Inborn Errors (8) · Nervous System Diseases (8) · Nutritional and Metabolic Diseases (8) · Brain Diseases, Metabolic (7) · Brain Diseases, Metabolic, Inborn (7) · Demyelinating Diseases (7) · Genetic Diseases, X-Linked (7)
Hydrocortisone (6) · Dehydroepiandrosterone (2) · Antilymphocyte Serum (1) · Biotin (1) · Bone Marrow Transplantation (1) · Busulfan (1) · Cholic Acid (1) · Cholic Acids (1) · Cortisone (1) · Cosyntropin (1) · Cyclophosphamide (1) · Fludrocortisone (1) · Plasma Exchange (1) · Stem Cell Transplantation (1) · Tablets (1)
Genetix Biotherapeutics Inc. (2) · Neurocrine UK Limited (2) · CMC Ambroise Paré (1) · Hadassah Medical Organization (1) · Haukeland University Hospital (1) · Masonic Cancer Center, University of Minnesota (1) · MedDay Pharmaceuticals SA (1) · Minoryx Therapeutics, S.L. (1) · Mirum Pharmaceuticals, Inc. (1) · Nantes University Hospital (1) · National Center for Research Resources (NCRR) (1) · Pujol, Aurora, M.D. (1) · Shire (1) · University Hospital Tuebingen (1) · University of Palermo (1)
France (8) · Germany (8) · United States (6) · United Kingdom (4) · Italy (3) · Netherlands (3) · Spain (3) · Argentina (1) · Australia (1) · Austria (1) · Belgium (1) · Hungary (1) · Israel (1) · Norway (1) · Portugal (1)
Paul Orchard, MD (2) · Adrian Thrasher, MD, PhD (1) · Anna G Nilsson, MD, PhD (1) · Charles L Sprung, MD (1) · Christine Duncan, MD (1) · David Williams, MD (1) · Didier Keh, MD (1) · Didier Pittet, MD (1) · Djillali Annane, MD (1) · Florian Eichler, MD (1) · Frederic Sedel, MD (1) · Gerhard Binder, PD Dr. med. (1) · Hernan Amartino, MD (1)
PMID 39383458, PMID 18184957, PMID 20103758, PMID 21586746, PMID 22073145, PMID 25066331, PMID 28644367, PMID 28976817, PMID 33236103, PMID 34980224, PMID 36681445, PMID 39171906, PMID 39383459
2009 (1), 2018 (1)